|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4436 |
Name | MSH2 |
Synonym | COCA1|FCC1|HNPCC|HNPCC1|LCFS2;mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli);MSH2;mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) |
Definition | DNA mismatch repair protein Msh2|hMSH2|mutS protein homolog 2 |
Position | 2p21 |
Gene Type | protein-coding |
Source | Count: 3; TAG,Generif,UniProt |
Literature support | Count: 1 PubMed records as below. |
|
Evidence Status |
Description |
potential | "tumor suppressor gene, hMSH2, may play an important role as a putative coactivator in ER alpha dependent gene expression." |
| More detail of all 1 literatures about MSH2 | |
|
Pathways and Diseases |
|
Pathway | Mismatch repair;KEGG PATHWAY;hsa03430 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Disease | Colorectal cancer;KEGG DISEASE;H00020 |
Disease | Cancers;KEGG DISEASE |
Disease | endometrial cancer;GAD |
Disease | Mismatch repair cancer syndrome;OMIM |
Disease | leukemia;GAD |
Disease | Female reproductive cancer;FunDO |
Disease | Muir-Torre syndrome;OMIM |
Disease | Colorectal cancer, hereditary nonpolyposis, type 1;OMIM |
Disease | CANCER;GAD |
Disease | Ovarian cancer;KEGG DISEASE;H00027 |
Disease | Testicular dysfunction;FunDO |
Disease | Gastritis;FunDO |
Disease | Cancer;FunDO |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Yersinia infection;FunDO |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | Lymphoma, Non-Hodgkin;GAD |
Disease | colorectal cancer;GAD |
|
External Links |
|
Links to Entrez Gene | 4436 |
Links to all GeneRIF Items | 4436 |
Links to iHOP | 4436 |
|
Sequence Information |
|
Nucleotide Sequence |
>4436 : length: 2805 atggcggtgcagccgaaggagacgctgcagttggagagcgcggccgaggtcggcttcgtg cgcttctttcagggcatgccggagaagccgaccaccacagtgcgccttttcgaccggggc gacttctatacggcgcacggcgaggacgcgctgctggccgcccgggaggtgttcaagacc cagggggtgatcaagtacatggggccggcaggagcaaagaatctgcagagtgttgtgctt agtaaaatgaattttgaatcttttgtaaaagatcttcttctggttcgtcagtatagagtt gaagtttataagaatagagctggaaataaggcatccaaggagaatgattggtatttggca tataaggcttctcctggcaatctctctcagtttgaagacattctctttggtaacaatgat atgtcagcttccattggtgttgtgggtgttaaaatgtccgcagttgatggccagagacag gttggagttgggtatgtggattccatacagaggaaactaggactgtgtgaattccctgat aatgatcagttctccaatcttgaggctctcctcatccagattggaccaaaggaatgtgtt ttacccggaggagagactgctggagacatggggaaactgagacagataattcaaagagga ggaattctgatcacagaaagaaaaaaagctgacttttccacaaaagacatttatcaggac ctcaaccggttgttgaaaggcaaaaagggagagcagatgaatagtgctgtattgccagaa atggagaatcaggttgcagtttcatcactgtctgcggtaatcaagtttttagaactctta tcagatgattccaactttggacagtttgaactgactacttttgacttcagccagtatatg aaattggatattgcagcagtcagagcccttaacctttttcagggttctgttgaagatacc actggctctcagtctctggctgccttgctgaataagtgtaaaacccctcaaggacaaaga cttgttaaccagtggattaagcagcctctcatggataagaacagaatagaggagagattg aatttagtggaagcttttgtagaagatgcagaattgaggcagactttacaagaagattta cttcgtcgattcccagatcttaaccgacttgccaagaagtttcaaagacaagcagcaaac ttacaagattgttaccgactctatcagggtataaatcaactacctaatgttatacaggct ctggaaaaacatgaaggaaaacaccagaaattattgttggcagtttttgtgactcctctt actgatcttcgttctgacttctccaagtttcaggaaatgatagaaacaactttagatatg gatcaggtggaaaaccatgaattccttgtaaaaccttcatttgatcctaatctcagtgaa ttaagagaaataatgaatgacttggaaaagaagatgcagtcaacattaataagtgcagcc agagatcttggcttggaccctggcaaacagattaaactggattccagtgcacagtttgga tattactttcgtgtaacctgtaaggaagaaaaagtccttcgtaacaataaaaactttagt actgtagatatccagaagaatggtgttaaatttaccaacagcaaattgacttctttaaat gaagagtataccaaaaataaaacagaatatgaagaagcccaggatgccattgttaaagaa attgtcaatatttcttcaggctatgtagaaccaatgcagacactcaatgatgtgttagct cagctagatgctgttgtcagctttgctcacgtgtcaaatggagcacctgttccatatgta cgaccagccattttggagaaaggacaaggaagaattatattaaaagcatccaggcatgct tgtgttgaagttcaagatgaaattgcatttattcctaatgacgtatactttgaaaaagat aaacagatgttccacatcattactggccccaatatgggaggtaaatcaacatatattcga caaactggggtgatagtactcatggcccaaattgggtgttttgtgccatgtgagtcagca gaagtgtccattgtggactgcatcttagcccgagtaggggctggtgacagtcaattgaaa ggagtctccacgttcatggctgaaatgttggaaactgcttctatcctcaggtctgcaacc aaagattcattaataatcatagatgaattgggaagaggaacttctacctacgatggattt gggttagcatgggctatatcagaatacattgcaacaaagattggtgctttttgcatgttt gcaacccattttcatgaacttactgccttggccaatcagataccaactgttaataatcta catgtcacagcactcaccactgaagagaccttaactatgctttatcaggtgaagaaaggt gtctgtgatcaaagttttgggattcatgttgcagagcttgctaatttccctaagcatgta atagagtgtgctaaacagaaagccctggaacttgaggagtttcagtatattggagaatcg caaggatatgatatcatggaaccagcagcaaagaagtgctatctggaaagagagcaaggt gaaaaaattattcaggagttcctgtccaaggtgaaacaaatgccctttactgaaatgtca gaagaaaacatcacaataaagttaaaacagctaaaagctgaagtaatagcaaagaataat agctttgtaaatgaaatcatttcacgaataaaagttactacgtga |
Protein Sequence |
>4436 : length: 934 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKT QGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLA YKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQD LNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYM KLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQA LEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSE LREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFS TVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLA QLDAVVSFAHVSNGAPVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKD KQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLK GVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMF ATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHV IECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMS EENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT |