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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 463 |
Name | ZFHX3 |
Synonym | ATBF1|ATBT|ZNF927;zinc finger homeobox 3;ZFHX3;zinc finger homeobox 3 |
Definition | AT motif-binding factor 1|AT-binding transcription factor 1|ZFH-3|alpha-fetoprotein enhancer binding protein|alpha-fetoprotein enhancer-binding protein|zinc finger homeobox protein 3|zinc finger homeodomain protein 3 |
Position | 16q22.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | ATBF1 associates with RUNX3 and translocates to the nucleus in response to TGF-beta signal transduction and might function in the nucleus as tumor suppressor and transcriptional regulator. |
potential | Prostate cancer linkage to the same region of 16q23 has been observed by others and the region contains several strong candidate genes including the known prostate cancer tumor suppressor genes ATBF1 and WWOX. |
| More detail of all 2 literatures about ZFHX3 | |
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Pathways and Diseases |
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Pathway | extrinsic prothrombin activation pathway;PID BioCarta;100168 |
Pathway | fibrinolysis pathway;PID BioCarta;100164 |
Pathway | intrinsic prothrombin activation pathway;PID BioCarta;100122 |
Pathway | C-MYB transcription factor network;PID Curated;200130 |
Disease | kawasaki disease;GAD |
Disease | Atrial Fibrillation;GAD |
Disease | Prostate cancer;FunDO |
Disease | Metastasis to lymph nodes;FunDO |
Disease | IMMUNE;GAD |
Disease | Multiple malignancy;FunDO |
Disease | CARDIOVASCULAR;GAD |
Disease | Prostate cancer, susceptibility to;OMIM |
Disease | Breast cancer;FunDO |
Disease | Stomach cancer;FunDO |
Disease | Liver cancer;FunDO |
Disease | Kawasaki disease;NHGRI |
Disease | Atrial fibrillation;NHGRI |
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External Links |
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Links to Entrez Gene | 463 |
Links to all GeneRIF Items | 463 |
Links to iHOP | 463 |
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Sequence Information |
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Nucleotide Sequence |
>463 : length: 8370 atgcggctcgggggcgggcagctggtgtcagaggagctgatgaacctgggcgagagcttc atccagaccaacgacccgtcgctgaagctcttccagtgcgccgtctgcaacaagttcacg acggacaacctggacatgctgggcctgcacatgaacgtggagcgcagcctgtcggaggac gagtggaaggcggtgatgggggactcataccagtgcaagctctgccgctacaacacccag ctcaaggccaacttccagctgcactgcaagacagacaagcacgtgcagaagtaccagctg gtggcccacatcaaggagggcggcaaggccaacgagtggaggctcaagtgtgtggccatc ggcaaccccgtgcacctcaagtgcaacgcctgtgactactacaccaacagcctggagaag ctgcggctgcacacggtcaactccaggcacgaggccagcctgaagttgtacaagcacctg cagcagcatgagagtggtgtagaaggtgagagctgctactaccactgcgttctgtgcaac tactccaccaaggccaagctcaacctcatccagcatgtgcgctccatgaagcaccagcga agcgagagcctgcgaaagctgcagcggctgcagaagggccttccagaggaggacgaggac ctggggcagatcttcaccatccgcaggtgcccctccacggacccagaagaagccattgaa gatgttgaaggacccagtgaaacagctgctgatccagaggagcttgctaaggaccaagag ggcggagcatcgtccagccaagcagagaaggagctgacagattctcctgcaacctccaaa cgcatctccttcccaggtagctcagagtctcccctctcttcgaagcgaccaaaaacagct gaggagatcaaaccggagcagatgtaccagtgtccctactgcaagtacagtaatgccgat gtcaaccggctccgggtgcatgccatgacgcagcactcggtgcaacccatgcttcgctgc cccctgtgccaggacatgctcaacaacaagatccacctccagctgcacctcacccacctc cacagcgtggcacctgactgcgtggagaagctcattatgacggtgaccacccctgagatg gtgatgccaagcagcatgttcctcccagcagctgttccagatcgagatgggaattccaat ttggaagaggcaggaaagcagcctgaaacctcagaggatctgggaaagaacatcttgcca tccgcaagcacagagcaaagcggagatttgaaaccatcccctgctgacccaggctctgtg agagaagactcaggcttcatctgctggaagaaggggtgcaaccaggttttcaaaacttct gctgcccttcagacgcattttaatgaagtgcatgccaagaggcctcagctgccggtgtca gatcgccatgtgtacaagtaccgctgtaatcagtgtagcctggccttcaagaccattgaa aagttgcagctccattctcagtaccatgtgatcagagctgccaccatgtgctgtctttgt cagcgcagtttccgaactttccaggctctgaagaagcaccttgagacaagccacctggag ctgagtgaggctgacatccaacagctttatggtggcctgctggccaatggggacctcctg gcaatgggagaccccactctggcagaggaccataccataattgttgaggaagacaaggag gaagagagtgacttggaagataaacagagcccaacgggcagtgactctgggtcagtacaa gaagactcgggctcagagccaaagagagctctgcctttcagaaaaggtcccaattttact atggaaaagttcctagacccttctcgcccttacaagtgtaccgtctgcaaggaatctttc actcaaaagaatatcctgctagtacactacaattctgtctcccacctgcataagttaaag agagcccttcaagaatcagcaaccggtcagccagaacccaccagcagcccagacaacaaa ccttttaagtgtaacacttgtaatgtggcctacagccagagttccactctggagatccat atgaggtctgtgttacatcaaaccaaggcccgggcagccaagctggaggctgcaagtggc agcagcaatgggactgggaacagcagcagtatttccttgagctcctccacgccaagtcct gtgagcaccagtggcagtaacacctttaccacctccaatccaagcagtgctggcattgct ccaagctctaacttactaagccaagtgcccactgagagtgtagggatgccacccctgggg aatcctattggtgccaacattgcttccccttcagagcccaaagaggccaatcggaagaaa ctggcagatatgattgcatccaggcagcagcaacaacagcagcagcaacagcaacaacaa caacaacaacaacaacaacaagcacaaacgctggcccaggcccaggctcaagttcaagct cacctgcagcaggagctgcagcaacaggctgccctgatccagtctcagctgtttaacccc accctccttcctcacttccccatgacaactgagaccctgctgcaactacagcagcagcag cacctcctcttccctttctacatccccagtgctgagttccagcttaaccccgaggtgagc ttgccagtgaccagtggggcactgacactgactgggacaggcccaggcctgctggaagat ctgaaggctcaggttcaggtcccacagcagagccatcagcagatcttgccgcagcagcag cagaaccaactctctatagcccagagtcactctgccctccttcagccaagccagcacccc gaaaagaagaacaaattggtcatcaaagaaaaggaaaaagaaagccagagagagagggac agcgccgaggggggagagggcaacaccggtccgaaggaaacactgccagatgccttgaag gccaaagagaagaaagagttggcaccagggggtggttctgagccttccatgctccctcca cgcattgcttcagatgccagagggaacgccaccaaggccctgctggagaactttggcttt gagttggtcatccagtataatgagaacaagcagaaggtgcagaaaaagaatgggaagact gaccagggagagaacctggaaaagctcgagtgtgactcctgcggcaagttgttttccaac atcttgattttaaagagtcatcaagagcacgttcatcagaattactttcctttcaaacag ctcgagaggtttgccaaacagtacagagaccactacgataaactgtacccactgaggccc cagaccccagagccaccaccacctccccctccaccccctccacccccacttccggcagcg ccgcctcagccggcgtccacaccagccatccccgcatcagccccacccatcacctcacct acaattgcaccggcccagccatcagtgccgctcacccagctctccatgccgatggagctg cccatcttctcgccgctgatgatgcagacgatgccgctgcagaccttgccggctcagcta cccccgcagctgggacctgtggagcctctgcctgcggacctggcccaactctaccagcat cagctcaatccaaccctgctccagcagcagaacaagaggcctcgcaccaggatcacagat gatcagctccgagtcttgcggcaatattttgacattaacaactcccccagtgaagagcaa ataaaagagatggcagacaagtccgggttgccccagaaagtgatcaagcactggttcagg aacactctcttcaaagagaggcagcgtaacaaggactccccttacaacttcagtaatcct cctatcaccagcctggaggagctcaagattgactcccggcccccttcgccggaacctcca aagcaggagtactggggaagcaagaggtcttcaagaacaaggtttacggactaccagctg agggtcttacaggacttcttcgatgccaatgcttacccaaaggatgatgaatttgagcaa ctctctaatttactgaaccttccaacccgagtgatagtggtgtggtttcagaatgcccga cagaaggccaggaagaattatgagaatcagggagagggcaaagatggagagcggcgtgag cttacaaatgatagatacattcgaacaagcaacttgaactaccagtgcaaaaaatgtagc ctggtgtttcagcgcatctttgatctcatcaagcaccagaagaagctgtgttacaaggat gaggatgaggaggggcaggacgacagccaaaatgaggattccatggatgccatggaaatc ctgacgcctaccagctcatcctgcagtaccccgatgccctcacaggcttacagcgcccca gcaccatcagccaataatacagcttcctccgctttcttgcagcttacagcggaggctgag gaactggccaccttcaattcaaaaacagaggcaggcgatgagaaaccaaagctggcggaa gctcccagtgcacagccaaaccaaacccaagaaaagcaaggacaaccaaagccagagctg cagcagcaagagcagcccgagcagaagaccaacactccccagcagaagctcccccagctg gtgtccctgccttcgttgccacagcctcctccacaagcgccccctccacagtgcccctta ccccagtcgagccccagtccttcccagctctcccacctgcccctcaagcccctccacaca tcaactcctcaacagctcgcaaacctacctcctcagctaatcccctaccagtgtgaccag tgtaagttggcatttccgtcatttgagcactggcaggagcatcagcagctccacttcctg agcgcgcagaaccagttcatccacccccagtttttggacaggtccctggatatgcctttc atgctctttgatcccagtaacccactcctggccagccagctgctctctggggccatacct cagattccagcaagctcagccacttctccttcaactccaacctccacaatgaacactctc aagaggaagctggaggaaaaggccagtgcaagccctggcgaaaacgacagtgggacagga ggagaagagcctcagagagacaagcgtttgagaacaaccatcacaccggaacaactagaa attctctaccagaagtatctactggattccaatccgactcgaaagatgttggatcacatt gcacacgaggtgggcttgaagaaacgtgtggtacaagtctggtttcagaacacccgagct cgggaaaggaaaggacagttccgggctgtaggcccagcgcaggcccacaggagatgccct ttttgcagagcgctcttcaaagccaagactgctcttgaggctcatatccggtcccgtcac tggcatgaagccaagagagctggctacaacctaactctgtctgcgatgctcttagactgt gatgggggactccagatgaaaggagatatttttgacggaactagcttttcccacctaccc ccaagcagtagtgatggtcagggtgtccccctctcacctgtgagtaaaaccatggaattg tcacccagaactcttctaagcccttcctccattaaggtggaagggattgaagactttgaa agcccctccatgtcctcagttaatctaaactttgaccaaactaagctggacaacgatgac tgttcctctgtcaacacagcaatcacagataccacaactggagacgagggcaacgcagat aacgacagtgcaacgggaatagcaactgaaaccaaatcctcttctgcacccaacgaaggg ttgaccaaagcggccatgatggcaatgtctgagtatgaagatcggttgtcatctggtctg gtcagcccggccccgagcttttatagcaaggaatatgacaatgaaggtacagtggactac agtgaaacctcaagccttgcagatccctgctccccgagtcctggtgcgagtggatctgca ggcaaatctggtgacagcggagatcggcctgggcagaaacgttttcgcactcaaatgacc aatctgcagctgaaggtcctcaagtcatgctttaatgactacaggacacccactatgcta gaatgtgaggtcctgggcaatgacattggactgccaaagagagtcgttcaggtctggttc cagaatgcccgggcaaaagaaaagaagtccaagttaagcatggccaagcattttggtata aaccaaacgagttatgagggacccaaaacagagtgcactttgtgtggcatcaagtacagc gctcggctgtctgtacgtgaccatatcttttcccaacagcatatctccaaagttaaagac accattggaagccagctggacaaggagaaagaatactttgacccagccaccgtacgtcag ttgatggctcaacaagagttggaccggattaaaaaggccaacgaggtccttggactggca gctcagcagcaagggatgtttgacaacacccctcttcaggcccttaaccttcctacagca tatccagcgctccagggcattcctcctgtgttgctcccgggcctcaacagcccctccttg ccaggctttactccatccaacacagctttaacgtctcctaagccgaacttgatgggtctg cccagcacaactgttccttcccctggcctccccacttctggattaccaaataaaccgtcc tcagcgtcgctgagctccccaaccccagcacaagccacgatggcgatgggccctcagcaa cccccccagcagcagcagcagcagcagcaaccacaggtgcagcagcctcccccgccgcca gcagcccagccgccacccacaccacagctcccactgcaacagcagcagcaacgcaaggac aaagacagtgagaaagtaaaggagaaggaaaaggcacacaaagggaaaggggaacccctg cctgtccccaagaaggagaaaggagaggcccccacggcaactgcagccacgatctcagcc ccgctgcccaccatggagtatgcggtagaccctgcacagctgcaggccctgcaggccgcg ttgacttcggaccccacagcattgctcacaagccagttccttccttactttgtaccaggc ttttctccttattatgctccccagatccctggcgccctgcagagcgggtacctgcagcct atgtatggcatggaaggcctgttcccctacagccctgcactgtcgcaggccctgatgggg ctgtccccaggctccctactgcagcagtaccagcaataccagcagagtctgcaggaggca attcagcagcagcagcagcggcaactacagcagcagcagcagcaaaaagtgcagcagcag cagcccaaagcaagccaaaccccagtcccccccggggctccttccccagacaaagaccct gccaaagaatcccccaaaccagaagaacagaaaaacaccccccgtgaggtgtcccccctc ctgccgaaactccctgaagagccagaagcagaaagcaaaagtgcggactccctctacgac cccttcattgttccaaaggtgcagtacaagttggtctgccgcaagtgccaggcgggcttc agcgacgaggaggcagcgaggagccacctgaagtccctctgcttcttcggccagtctgtg gtgaacctgcaagagatggtgcttcacgtccccaccggcggcggcggcggtggcagtggc ggcggcggcggcggtggcggcggcggcggcggcggcggctcgtaccactgcctggcgtgc gagagcgcgctctgtggggaggaagctctgagtcaacatctcgagtcggccttgcacaaa cacagaacaatcacgagagcagcaagaaacgccaaagagcaccctagtttattacctcac tctgcctgcttccccgatcctagcaccgcatctacctcgcagtctgccgctcactcaaac gacagcccccctcccccgtcggccgccgccccctcctccgcttccccccacgcctccagg aagtcttggccgcaagtggtctcccgggcttcggcagcgaagcccccttcttttcctcct ctctcctcatcttcaacggttacctcaagttcatgcagcacctcaggggttcagccctcg atgccaacagacgactattcggaggagtctgacacggatctcagccaaaagtccgacgga ccggcgagcccggtggagggtcccaaagaccccagctgccccaaggacagtggtctgacc agtgtaggaacggacaccttcagattgtaa |
Protein Sequence |
>463 : length: 2789 MRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSED EWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAI GNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCN YSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIE DVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTA EEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHL HSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSEDLGKNILP SASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTHFNEVHAKRPQLPVS DRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLE LSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQ EDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLK RALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASG SSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLLSQVPTESVGMPPLG NPIGANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQQAQTLAQAQAQVQA HLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVS LPVTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSIAQSHSALLQPSQHP EKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKELAPGGGSEPSMLPP RIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTDQGENLEKLECDSCGKLFSN ILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPPPPPPPPPPPPLPAA PPQPASTPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQL PPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQ IKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPP KQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNAR QKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKD EDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAE ELATFNSKTEAGDEKPKLAEAPSAQPNQTQEKQGQPKPELQQQEQPEQKTNTPQQKLPQL VSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQ CKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIP QIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLE ILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCP FCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLP PSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDD CSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAMMAMSEYEDRLSSGL VSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDSGDRPGQKRFRTQMT NLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGI NQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQ LMAQQELDRIKKANEVLGLAAQQQGMFDNTPLQALNLPTAYPALQGIPPVLLPGLNSPSL PGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMGPQQ PPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKDSEKVKEKEKAHKGKGEPL PVPKKEKGEAPTATAATISAPLPTMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPG FSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSLLQQYQQYQQSLQEA IQQQQQRQLQQQQQQKVQQQQPKASQTPVPPGAPSPDKDPAKESPKPEEQKNTPREVSPL LPKLPEEPEAESKSADSLYDPFIVPKVQYKLVCRKCQAGFSDEEAARSHLKSLCFFGQSV VNLQEMVLHVPTGGGGGGSGGGGGGGGGGGGGGSYHCLACESALCGEEALSQHLESALHK HRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAAPSSASPHASR KSWPQVVSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDG PASPVEGPKDPSCPKDSGLTSVGTDTFRL |