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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 472 |
Name | ATM |
Synonym | AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1;ataxia telangiectasia mutated;ATM;ataxia telangiectasia mutated |
Definition | A-T mutated|AT mutated|TEL1, telomere maintenance 1, homolog|serine-protein kinase ATM |
Position | 11q22-q23 |
Gene Type | protein-coding |
Source | Count: 2; Generif,UniProt |
Literature support | Count: 5 PubMed records as below. |
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Evidence Status |
Description |
reviewed | these results elucidate a novel mechanism through which the TGF-beta pathway regulates the cancer stem cells property by interfering with the tumor suppressor ATM. |
reviewed | analysis of the three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with. |
reviewed | results indicate that KSHV vIRF1 comprehensively compromises an ATM/p53-mediated DNA damage response checkpoint by targeting both upstream ATM kinase and downstream p53 tumor suppressor. |
reviewed | "The tumor suppressor function of HINT1 is caused by, at least in part, its normal role in enhancing cellular responses to DNA damage by regulating the functions of both gamma-H2AX and ATM." |
reviewed | p53 retains tumor suppressor activity in the absence of Atm. |
| More detail of all 5 literatures about ATM | |
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Pathways and Diseases |
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Pathway | Homologous recombination repair of replication-independent double-strand breaks;PID Reactome;500937 |
Pathway | BARD1 signaling events;PID Curated;200174 |
Pathway | role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234 |
Pathway | G2/M DNA damage checkpoint;PID Reactome;500952 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | ATM mediated response to DNA double-strand break;PID Reactome;500042 |
Pathway | cell cycle: g2/m checkpoint;PID BioCarta;100159 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PID Reactome;500938 |
Pathway | ATM mediated phosphorylation of repair proteins;PID Reactome;500043 |
Pathway | tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237 |
Pathway | atm signaling pathway;PID BioCarta;100235 |
Pathway | rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | hypoxia and p53 in the cardiovascular system;PID BioCarta;100084 |
Pathway | Stabilization of p53;PID Reactome;500316 |
Pathway | Recruitment of repair and signaling proteins to double-strand breaks;PID Reactome;500044 |
Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | cdc25 and chk1 regulatory pathway in response to dna damage;PID BioCarta;100212 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | apoptotic signaling in response to dna damage;PID BioCarta;100204 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | Autodegradation of the E3 ubiquitin ligase COP1;PID Reactome;500317 |
Pathway | p38 MAPK signaling pathway;PID Curated;200014 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Disease | Ataxia telangiectasia;KEGG DISEASE;H00064 |
Disease | Immune system diseases;KEGG DISEASE |
Disease | T-cell prolymphocytic leukemia, sporadic;OMIM |
Disease | DNA repair defect;KEGG DISEASE;H00094 |
Disease | Nervous system diseases;KEGG DISEASE |
Disease | Immunologic deficiency syndrome;FunDO |
Disease | fibrosis, subcutaneous;GAD |
Disease | Fanconi's anemia;FunDO |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | Rheumatoid arthritis;FunDO |
Disease | prostate cancer;GAD |
Disease | Lymphoma, B-cell non-Hodgkin, somatic;OMIM |
Disease | ataxia-telangiectasia;GAD |
Disease | Ataxia-telangiectasia;OMIM |
Disease | radiotherapy response;GAD |
Disease | Adenovirus infection;FunDO |
Disease | diffuse large B-cell lymphoma;GAD |
Disease | CANCER;GAD |
Disease | Infection;FunDO |
Disease | Lymphoma, mantle cell;OMIM |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Hodgkin's disease;GAD |
Disease | Cancers;KEGG DISEASE |
Disease | breast cancer;GAD |
Disease | Chronic lymphocytic leukemia (CLL);KEGG DISEASE;H00005 |
Disease | Breast cancer, susceptibility to;OMIM |
Disease | endometrial cancer;GAD |
Disease | Neurodegenerative diseases;KEGG DISEASE |
Disease | Cancer;FunDO |
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External Links |
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Links to Entrez Gene | 472 |
Links to all GeneRIF Items | 472 |
Links to iHOP | 472 |
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Sequence Information |
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Nucleotide Sequence |
>472 : length: 9171 atgagtctagtacttaatgatctgcttatctgctgccgtcaactagaacatgatagagct acagaacgaaagaaagaagttgagaaatttaagcgcctgattcgagatcctgaaacaatt aaacatctagatcggcattcagattccaaacaaggaaaatatttgaattgggatgctgtt tttagatttttacagaaatatattcagaaagaaacagaatgtctgagaatagcaaaacca aatgtatcagcctcaacacaagcctccaggcagaaaaagatgcaggaaatcagtagtttg gtcaaatacttcatcaaatgtgcaaacagaagagcacctaggctaaaatgtcaagaactc ttaaattatatcatggatacagtgaaagattcatctaatggtgctatttacggagctgat tgtagcaacatactactcaaagacattctttctgtgagaaaatactggtgtgaaatatct cagcaacagtggttagaattgttctctgtgtacttcaggctctatctgaaaccttcacaa gatgttcatagagttttagtggctagaataattcatgctgttaccaaaggatgctgttct cagactgacggattaaattccaaatttttggactttttttccaaggctattcagtgtgcg agacaagaaaagagctcttcaggtctaaatcatatcttagcagctcttactatcttcctc aagactttggctgtcaactttcgaattcgagtgtgtgaattaggagatgaaattcttccc actttgctttatatttggactcaacataggcttaatgattctttaaaagaagtcattatt gaattatttcaactgcaaatttatatccatcatccgaaaggagccaaaacccaagaaaaa ggtgcttatgaatcaacaaaatggagaagtattttatacaacttatatgatctgctagtg aatgagataagtcatataggaagtagaggaaagtattcttcaggatttcgtaatattgcc gtcaaagaaaatttgattgaattgatggcagatatctgtcaccaggtttttaatgaagat accagatccttggagatttctcaatcttacactactacacaaagagaatctagtgattac agtgtcccttgcaaaaggaagaaaatagaactaggctgggaagtaataaaagatcacctt cagaagtcacagaatgattttgatcttgtgccttggctacagattgcaacccaattaata tcaaagtatcctgcaagtttacctaactgtgagctgtctccattactgatgatactatct cagcttctaccccaacagcgacatggggaacgtacaccatatgtgttacgatgccttacg gaagttgcattgtgtcaagacaagaggtcaaacctagaaagctcacaaaagtcagattta ttaaaactctggaataaaatttggtgtattacctttcgtggtataagttctgagcaaata caagctgaaaactttggcttacttggagccataattcagggtagtttagttgaggttgac agagaattctggaagttatttactgggtcagcctgcagaccttcatgtcctgcagtatgc tgtttgactttggcactgaccaccagtatagttccaggaacggtaaaaatgggaatagag caaaatatgtgtgaagtaaatagaagcttttctttaaaggaatcaataatgaaatggctc ttattctatcagttagagggtgacttagaaaatagcacagaagtgcctccaattcttcac agtaattttcctcatcttgtactggagaaaattcttgtgagtctcactatgaaaaactgt aaagctgcaatgaattttttccaaagcgtgccagaatgtgaacaccaccaaaaagataaa gaagaactttcattctcagaagtagaagaactatttcttcagacaacttttgacaagatg gactttttaaccattgtgagagaatgtggtatagaaaagcaccagtccagtattggcttc tctgtccaccagaatctcaaggaatcactggatcgctgtcttctgggattatcagaacag cttctgaataattactcatctgagattacaaattcagaaactcttgtccggtgttcacgt cttttggtgggtgtccttggctgctactgttacatgggtgtaatagctgaagaggaagca tataagtcagaattattccagaaagccaagtctctaatgcaatgtgcaggagaaagtatc actctgtttaaaaataagacaaatgaggaattcagaattggttccttgagaaatatgatg cagctatgtacacgttgcttgagcaactgtaccaagaagagtccaaataagattgcatct ggctttttcctgcgattgttaacatcaaagctaatgaatgacattgcagatatttgtaaa agtttagcatccttcatcaaaaagccatttgaccgtggagaagtagaatcaatggaagat gatactaatggaaatctaatggaggtggaggatcagtcatccatgaatctatttaacgat taccctgatagtagtgttagtgatgcaaacgaacctggagagagccaaagtaccataggt gccattaatcctttagctgaagaatatctgtcaaagcaagatctacttttcttagacatg ctcaagttcttgtgtttgtgtgtaactactgctcagaccaatactgtgtcctttagggca gctgatattcggaggaaattgttaatgttaattgattctagcacgctagaacctaccaaa tccctccacctgcatatgtatctaatgcttttaaaggagcttcctggagaagagtacccc ttgccaatggaagatgttcttgaacttctgaaaccactatccaatgtgtgttctttgtat cgtcgtgaccaagatgtttgtaaaactattttaaaccatgtccttcatgtagtgaaaaac ctaggtcaaagcaatatggactctgagaacacaagggatgctcaaggacagtttcttaca gtaattggagcattttggcatctaacaaaggagaggaaatatatattctctgtaagaatg gccctagtaaattgccttaaaactttgcttgaggctgatccttattcaaaatgggccatt cttaatgtaatgggaaaagactttcctgtaaatgaagtatttacacaatttcttgctgac aatcatcaccaagttcgcatgttggctgcagagtcaatcaatagattgttccaggacacg aagggagattcttccaggttactgaaagcacttcctttgaagcttcagcaaacagctttt gaaaatgcatacttgaaagctcaggaaggaatgagagaaatgtcccatagtgctgagaac cctgaaactttggatgaaatttataatagaaaatctgttttactgacgttgatagctgtg gttttatcctgtagccctatctgcgaaaaacaggctttgtttgccctgtgtaaatctgtg aaagagaatggattagaacctcaccttgtgaaaaaggttttagagaaagtttctgaaact tttggatatagacgtttagaagactttatggcatctcatttagattatctggttttggaa tggctaaatcttcaagatactgaatacaacttatcttcttttccttttattttattaaac tacacaaatattgaggatttctatagatcttgttataaggttttgattccacatctggtg attagaagtcattttgatgaggtgaagtccattgctaatcagattcaagaggactggaaa agtcttctaacagactgctttccaaagattcttgtaaatattcttccttattttgcctat gagggtaccagagacagtgggatggcacagcaaagagagactgctaccaaggtctatgat atgcttaaaagtgaaaacttattgggaaaacagattgatcacttattcattagtaattta ccagagattgtggtggagttattgatgacgttacatgagccagcaaattctagtgccagt cagagcactgacctctgtgacttttcaggggatttggatcctgctcctaatccacctcat tttccatcgcatgtgattaaagcaacatttgcctatatcagcaattgtcataaaaccaag ttaaaaagcattttagaaattctttccaaaagccctgattcctatcagaaaattcttctt gccatatgtgagcaagcagctgaaacaaataatgtttataagaagcacagaattcttaaa atatatcacctgtttgttagtttattactgaaagatataaaaagtggcttaggaggagct tgggcctttgttcttcgagacgttatttatactttgattcactatatcaaccaaaggcct tcttgtatcatggatgtgtcattacgtagcttctccctttgttgtgacttattaagtcag gtttgccagacagccgtgacttactgtaaggatgctctagaaaaccatcttcatgttatt gttggtacacttataccccttgtgtatgagcaggtggaggttcagaaacaggtattggac ttgttgaaatacttagtgatagataacaaggataatgaaaacctctatatcacgattaag cttttagatccttttcctgaccatgttgtttttaaggatttgcgtattactcagcaaaaa atcaaatacagtagaggacccttttcactcttggaggaaattaaccattttctctcagta agtgtttatgatgcacttccattgacaagacttgaaggactaaaggatcttcgaagacaa ctggaactacataaagatcagatggtggacattatgagagcttctcaggataatccgcaa gatgggattatggtgaaactagttgtcaatttgttgcagttatccaagatggcaataaac cacactggtgaaaaagaagttctagaggctgttggaagctgcttgggagaagtgggtcct atagatttctctaccatagctatacaacatagtaaagatgcatcttataccaaggccctt aagttatttgaagataaagaacttcagtggaccttcataatgctgacctacctgaataac acactggtagaagattgtgtcaaagttcgatcagcagctgttacctgtttgaaaaacatt ttagccacaaagactggacatagtttctgggagatttataagatgacaacagatccaatg ctggcctatctacagccttttagaacatcaagaaaaaagtttttagaagtacccagattt gacaaagaaaacccttttgaaggcctggatgatataaatctgtggattcctctaagtgaa aatcatgacatttggataaagacactgacttgtgcttttttggacagtggaggcacaaaa tgtgaaattcttcaattattaaagccaatgtgtgaagtgaaaactgacttttgtcagact gtacttccatacttgattcatgatattttactccaagatacaaatgaatcatggagaaat ctgctttctacacatgttcagggatttttcaccagctgtcttcgacacttctcgcaaacg agccgatccacaacccctgcaaacttggattcagagtcagagcactttttccgatgctgt ttggataaaaaatcacaaagaacaatgcttgctgttgtggactacatgagaagacaaaag agaccttcttcaggaacaatttttaatgatgctttctggctggatttaaattatctagaa gttgccaaggtagctcagtcttgtgctgctcactttacagctttactctatgcagaaatc tatgcagataagaaaagtatggatgatcaagagaaaagaagtcttgcatttgaagaagga agccagagtacaactatttctagcttgagtgaaaaaagtaaagaagaaactggaataagt ttacaggatcttctcttagaaatctacagaagtataggggagccagatagtttgtatggc tgtggtggagggaagatgttacaacccattactagactacgaacatatgaacacgaagca atgtggggcaaagccctagtaacatatgacctcgaaacagcaatcccctcatcaacacgc caggcaggaatcattcaggccttgcagaatttgggactctgccatattctttccgtctat ttaaaaggattggattatgaaaataaagactggtgtcctgaactagaagaacttcattac caagcagcatggaggaatatgcagtgggaccattgcacttccgtcagcaaagaagtagaa ggaaccagttaccatgaatcattgtacaatgctctacaatctctaagagacagagaattc tctacattttatgaaagtctcaaatatgccagagtaaaagaagtggaagagatgtgtaag cgcagccttgagtctgtgtattcgctctatcccacacttagcaggttgcaggccattgga gagctggaaagcattggggagcttttctcaagatcagtcacacatagacaactctctgaa gtatatattaagtggcagaaacactcccagcttctcaaggacagtgattttagttttcag gagcctatcatggctctacgcacagtcattttggagatcctgatggaaaaggaaatggac aactcacaaagagaatgtattaaggacattctcaccaaacaccttgtagaactctctata ctggccagaactttcaagaacactcagctccctgaaagggcaatatttcaaattaaacag tacaattcagttagctgtggagtctctgagtggcagctggaagaagcacaagtattctgg gcaaaaaaggagcagagtcttgccctgagtattctcaagcaaatgatcaagaagttggat gccagctgtgcagcgaacaatcccagcctaaaacttacatacacagaatgtctgagggtt tgtggcaactggttagcagaaacgtgcttagaaaatcctgcggtcatcatgcagacctat ctagaaaaggcagtagaagttgctggaaattatgatggagaaagtagtgatgagctaaga aatggaaaaatgaaggcatttctctcattagcccggttttcagatactcaataccaaaga attgaaaactacatgaaatcatcggaatttgaaaacaagcaagctctcctgaaaagagcc aaagaggaagtaggtctccttagggaacataaaattcagacaaacagatacacagtaaag gttcagcgagagctggagttggatgaattagccctgcgtgcactgaaagaggatcgtaaa cgcttcttatgtaaagcagttgaaaattatatcaactgcttattaagtggagaagaacat gatatgtgggtattccgactttgttccctctggcttgaaaattctggagtttctgaagtc aatggcatgatgaagagagacggaatgaagattccaacatataaatttttgcctcttatg taccaattggctgctagaatggggaccaagatgatgggaggcctaggatttcatgaagtc ctcaataatctaatctctagaatttcaatggatcacccccatcacactttgtttattata ctggccttagcaaatgcaaacagagatgaatttctgactaaaccagaggtagccagaaga agcagaataactaaaaatgtgcctaaacaaagctctcagcttgatgaggatcgaacagag gctgcaaatagaataatatgtactatcagaagtaggagacctcagatggtcagaagtgtt gaggcactttgtgatgcttatattatattagcaaacttagatgccactcagtggaagact cagagaaaaggcataaatattccagcagaccagccaattactaaacttaagaatttagaa gatgttgttgtccctactatggaaattaaggtggaccacacaggagaatatggaaatctg gtgactatacagtcatttaaagcagaatttcgcttagcaggaggtgtaaatttaccaaaa ataatagattgtgtaggttccgatggcaaggagaggagacagcttgttaagggccgtgat gacctgagacaagatgctgtcatgcaacaggtcttccagatgtgtaatacattactgcag agaaacacggaaactaggaagaggaaattaactatctgtacttataaggtggttcccctc tctcagcgaagtggtgttcttgaatggtgcacaggaactgtccccattggtgaatttctt gttaacaatgaagatggtgctcataaaagatacaggccaaatgatttcagtgcctttcag tgccaaaagaaaatgatggaggtgcaaaaaaagtcttttgaagagaaatatgaagtcttc atggatgtttgccaaaattttcaaccagttttccgttacttctgcatggaaaaattcttg gatccagctatttggtttgagaagcgattggcttatacgcgcagtgtagctacttcttct attgttggttacatacttggacttggtgatagacatgtacagaatatcttgataaatgag cagtcagcagaacttgtacatatagatctaggtgttgcttttgaacagggcaaaatcctt cctactcctgagacagttccttttagactcaccagagatattgtggatggcatgggcatt acgggtgttgaaggtgtcttcagaagatgctgtgagaaaaccatggaagtgatgagaaac tctcaggaaactctgttaaccattgtagaggtccttctatatgatccactctttgactgg accatgaatcctttgaaagctttgtatttacagcagaggccggaagatgaaactgagctt caccctactctgaatgcagatgaccaagaatgcaaacgaaatctcagtgatattgaccag agtttcaacaaagtagctgaacgtgtcttaatgagactacaagagaaactgaaaggagtg gaagaaggcactgtgctcagtgttggtggacaagtgaatttgctcatacagcaggccata gaccccaaaaatctcagccgacttttcccaggatggaaagcttgggtgtga |
Protein Sequence |
>472 : length: 3056 MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAV FRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQEL LNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQ DVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFL KTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEK GAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNED TRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLI SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDL LKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC CLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILH SNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKM DFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSR LLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMM QLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMED DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDM LKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP LPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLT VIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLAD NHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAEN PETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSET FGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLV IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPH FPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILK IYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQ VCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIK LLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQ LELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGP IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNI LATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSE NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRN LLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQK RPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEG SQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEA MWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHY QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCK RSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQ EPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQ YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQR IENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK RFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLM YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARR SRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKT QRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPK IIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPL SQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVF MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINE QSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQ SFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV |