Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

4824

Name

NKX3-1

Synonym

BAPX2|NKX3|NKX3.1|NKX3A;NK3 homeobox 1;NKX3-1;NK3 homeobox 1

Definition

NK homeobox, family 3, A|NK3 transcription factor homolog A|NK3 transcription factor related, locus 1|homeobox protein NK-3 homolog A|homeobox protein Nkx-3.1

Position

8p21.2

Gene Type

protein-coding

Source

Count: 3; Pubmed_search,Generif,UniProt

Literature support

Count: 4 PubMed records as below.

Evidence Status

Description

reviewed

The prostate-specific tumor suppressor gene Nkx3.1 was controlled by ERG and ESE3 both directly and through induction of EZH2.

reviewed

cellular levels of the NKX3.1 tumor suppressor are affected by inflammatory cytokines that target COOH-terminal serine residues to activate ubiquitination and protein degradation.

reviewed

Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.

reviewed

NKX3.1 does not function as a typical tumor suppressor protein in prostate cancer but it may still have important regulatory roles during prostate cancer progression.
More detail of all 4 literatures about NKX3-1

Pathways and Diseases

Pathway

Coregulation of Androgen receptor activity;PID Curated;200038

Pathway

FOXA1 transcription factor network;PID Curated;200194

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Disease

Cancers;KEGG DISEASE

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

Prostate cancer;KEGG DISEASE;H00024

Disease

Prostate cancer;NHGRI

Disease

prostate cancer;GAD

Disease

CANCER;GAD

External Links

Links to Entrez Gene

4824

Links to all GeneRIF Items

4824

Links to iHOP

4824

Sequence Information

Nucleotide Sequence

>4824 : length: 705
atgctcagggttccggagccgcggcccggggaggcgaaagcggagggggccgcgccgccg
accccgtccaagccgctcacgtccttcctcatccaggacatcctgcgggacggcgcgcag
cggcaaggcggccgcacgagcagccagagacagcgcgacccggagccggagccagagcca
gagccagagggaggacgcagccgcgccggggcgcagaacgaccagctgagcaccgggccc
cgcgccgcgccggaggaggccgagacgctggcagagaccgagccagaaaggcacttgggg
tcttatctgttggactctgaaaacacttcaggcgcccttccaaggcttccccaaacccct
aagcagccgcagaagcgctcccgagctgccttctcccacactcaggtgatcgagttggag
aggaagttcagccatcagaagtacctgtcggcccctgaacgggcccacctggccaagaac
ctcaagctcacggagacccaagtgaagatatggttccagaacagacgctataagactaag
cgaaagcagctctcctcggagctgggagacttggagaagcactcctctttgccggccctg
aaagaggaggccttctcccgggcctccctggtctccgtgtataacagctatccttactac
ccatacctgtactgcgtgggcagctggagcccagctttttggtaa

Protein Sequence

>4824 : length: 234
MLRVPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQRQGGRTSSQRQRDPEPEPEP
EPEGGRSRAGAQNDQLSTGPRAAPEEAETLAETEPERHLGSYLLDSENTSGALPRLPQTP
KQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTK
RKQLSSELGDLEKHSSLPALKEEAFSRASLVSVYNSYPYYPYLYCVGSWSPAFW



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