Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5320

Name

PLA2G2A

Synonym

MOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2;phospholipase A2, group IIA (platelets, synovial fluid);PLA2G2A;phospholipase A2, group IIA (platelets, synovial fluid)

Definition

GIIC sPLA2|NPS-PLA2|group IIA phospholipase A2|non-pancreatic secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 2A|phospholipase A2, membrane associated

Position

1p35

Gene Type

protein-coding

Source

Count: 2; TAG,Generif

Literature support

Count: 1 PubMed records as below.

Evidence Status

Description

potential

"Here, we report that a cosmid transgene overexpressing Pla2g2a caused a reduction in tumour multiplicity and size, comparable to that conferred by a single copy of the resistance allele of Mom1. These results offer strong evidence that this secretory phospholipase can provide active tumour resistance. ".
More detail of all 1 literatures about PLA2G2A

Pathways and Diseases

Pathway

Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270

Pathway

VEGF signaling pathway;KEGG PATHWAY;hsa04370

Pathway

Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664

Pathway

Pancreatic secretion;KEGG PATHWAY;hsa04972

Pathway

Toxoplasmosis;KEGG PATHWAY;hsa05145

Pathway

Glypican 1 network;PID Curated;200021

Pathway

phospholipases;BioCyc;LIPASYN-PWY

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Metabolic pathways;KEGG PATHWAY;hsa01100

Pathway

Glycerophospholipid metabolism;KEGG PATHWAY;hsa00564

Pathway

alpha-Linolenic acid metabolism;KEGG PATHWAY;hsa00592

Pathway

Long-term depression;KEGG PATHWAY;hsa04730

Pathway

Ether lipid metabolism;KEGG PATHWAY;hsa00565

Pathway

Linoleic acid metabolism;KEGG PATHWAY;hsa00591

Pathway

GnRH signaling pathway;KEGG PATHWAY;hsa04912

Pathway

Arachidonic acid metabolism;KEGG PATHWAY;hsa00590

Disease

Drug abuse;FunDO

Disease

Embryoma;FunDO

Disease

PSYCH;GAD

Disease

Diabetes mellitus;FunDO

Disease

Cystic fibrosis;FunDO

Disease

Vascular dementia;FunDO

Disease

Colorectal cancer;OMIM

Disease

Schizophrenia;FunDO

Disease

Dental plaque;FunDO

Disease

Cholelithiasis;FunDO

Disease

Stroke;FunDO

Disease

Stomach cancer;FunDO

Disease

Alzheimer's disease;FunDO

Disease

affective disorder;GAD

Disease

Neoplasm metastasis;FunDO

Disease

Atherosclerosis;FunDO

External Links

Links to Entrez Gene

5320

Links to all GeneRIF Items

5320

Links to iHOP

5320

Sequence Information

Nucleotide Sequence

>5320 : length: 435
atgaagaccctcctactgttggcagtgatcatgatctttggcctactgcaggcccatggg
aatttggtgaatttccacagaatgatcaagttgacgacaggaaaggaagccgcactcagt
tatggcttctacggctgccactgtggcgtgggtggcagaggatcccccaaggatgcaacg
gatcgctgctgtgtcactcatgactgttgctacaaacgtctggagaaacgtggatgtggc
accaaatttctgagctacaagtttagcaactcggggagcagaatcacctgtgcaaaacag
gactcctgcagaagtcaactgtgtgagtgtgataaggctgctgccacctgttttgctaga
aacaagacgacctacaataaaaagtaccagtactattccaataaacactgcagagggagc
acccctcgttgctga

Protein Sequence

>5320 : length: 144
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC



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