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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5331 |
Name | PLCB3 |
Synonym | -;phospholipase C, beta 3 (phosphatidylinositol-specific);PLCB3;phospholipase C, beta 3 (phosphatidylinositol-specific) |
Definition | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3|PLC beta 3|PLC-beta-3|phosphoinositide phospholipase C-beta-3 |
Position | 11q13 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | "PLCB3 plays an important role in signal transduction and, moreover, shows loss of expression in some endocrine tumors, in accordance with a putative tumor suppressor gene function, and thus appears to be an excellent candidate for MEN1." |
potential | Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene. |
| More detail of all 2 literatures about PLCB3 | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | 2-arachidonoylglycerol biosynthesis;PANTHER;P05726 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Alpha adrenergic receptor signaling pathway;PANTHER;P00002 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Endogenous cannabinoid signaling;PANTHER;P05730 |
Pathway | D-myo-inositol (1,4,5)-trisphosphate biosynthesis;BioCyc;PWY-6351 |
Pathway | D-myo-inositol-5-phosphate metabolism;BioCyc;PWY-6367 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Synaptic Transmission;Reactome;REACT:13685 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Pancreatic secretion;KEGG PATHWAY;hsa04972 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | phospholipases;BioCyc;LIPASYN-PWY |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Gastric acid secretion;KEGG PATHWAY;hsa04971 |
Disease | Longevity;NHGRI |
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External Links |
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Links to Entrez Gene | 5331 |
Links to all GeneRIF Items | 5331 |
Links to iHOP | 5331 |
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Sequence Information |
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Nucleotide Sequence |
>5331 : length: 3705 atggcgggcgcccagcccggcgtccacgcgctgcagttggagccgcccaccgtggtggag accctgcggcgcgggagtaagttcatcaaatgggacgaggagacctccagtcggaacctg gtgaccctgcgtgtggaccccaatggcttcttcttgtactggacgggccccaacatggag gtggacacactggacatcagttccatcagggacacacggacaggccggtacgcccgcctg cccaaggaccccaagatccgggaagttctgggctttgggggtcccgatgcccggctggag gagaagctgatgacggtggtgtctgggccagacccagtgaacacagtgttcttgaacttc atggccgtgcaggatgacacagccaaggtctggtctgaggagctattcaagctggctatg aacatcctggctcagaacgcctcccggaacaccttcctgcgcaaagcatacacgaagctg aagctgcaggtgaaccaggatggtcggatccccgtcaagaacatcctgaagatgttctca gcagacaagaagcgggtggagactgcgctggaatcctgtggcctcaaattcaaccggagt gagtccatccggcctgatgagttttccttggaaatctttgagcggttcctgaacaagctg tgtctgcggccggacattgacaagatcctgctggagataggcgccaagggcaagccatac ctgacgctggagcagctcatggacttcatcaaccagaagcaacgcgacccgagactcaac gaagtgctgtacccgcccctgcggccctcccaggcccggctgctcatcgaaaagtatgag cccaaccagcagtttctggagcgagaccagatgtccatggagggctttagccgctacctg ggaggcgaggagaatggcatcctgcccctggaagccctggatctgagcacggacatgacc cagccactgagtgcctacttcatcaactcctcgcataacacctatctcactgcggggcag ctggctgggacctcgtcggtggagatgtaccgccaggcactactatggggctgccgctgc gtggagctggacgtgtggaagggacggccgcctgaggaggaacccttcattacccacggc ttcaccatgaccacagaggtgcctctgcgcgacgtgctggaggccattgccgagactgcc ttcaagacctcgccctaccccgtcatcctctccttcgagaaccatgtggactcggcaaag caacaggcaaagatggctgagtactgccgctccatctttggagacgcgctactcatcgag cctctggacaagtacccgctggccccaggcgttcccctgcccagcccccaggacctgatg ggccgtatcctggtgaagaacaagaagcggcaccgacccagcgcaggtggcccagacagc gccgggcgcaagcggcccctggagcagagcaattctgccctgagcgagagctccgcggcc accgagccctcctccccgcagctggggtctcccagctctgacagctgcccaggcctgagc aatggggaggaggtagggcttgagaagcccagcctggagcctcagaagtctctgggtgac gagggcctgaaccgaggcccctatgttcttggacctgctgaccgtgaggatgaggaggaa gatgaggaagaggaggaacagacagaccccaaaaagccaactacagatgagggcacagcc agcagcgaggtgaatgccactgaggagatgtccacgcttgtcaactacatcgaacctgtc aagttcaagtcctttgaggctgctcgaaagaggaacaaatgcttcgagatgtcgtccttt gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac aagcagcagctcagccgcatctaccccaagggcacccgcgtggactcctccaactacatg ccccagctcttctggaacgtagggtgccagcttgttgcgctcaacttccagaccctcgat gtggcgatgcagctcaacgcgggcgtttttgagtacaacgggcgcagcgggtacctgctc aagccggagttcatgcggcggccggacaagtccttcgaccccttcactgaggtcatcgtg gatggcatcgtggccaatgccttgcgggtcaaggtgatctcagggcagttcctgtccgac aggaaggtgggcatctacgtggaggtggacatgtttggcctccctgttgatacgcggcgc aagtaccgcacccggacctctcaggggaactcgttcaaccccgtgtgggacgaagagccc ttcgacttccccaaggtggtgctgcccacgctggcttcacttcgcattgcagcctttgag gaggggggtaaattcgtagggcaccggatcctgcctgtctctgccatccgctccggatac cactacgtctgcctgcggaacgaggccaaccaaccgctgtgcctgccggccctgctcatc tacaccgaagcctcggactacattcctgacgaccaccaggactatgcggaggccctgatc aaccccattaagcacgtcagcctgatggaccagagggcccggcagctggccgccctcatt ggggagagtgaggctcaggctggccaagagacgtgccaggacacccagtctcagcagctg gggtctcagccgtcctcaaaccccacccccagcccactggatgcctccccccgccggccc cctggccccaccacctcccctgccagcacctccctcagcagcccagggcagcgtgatgat ctcatcgccagcatcctctcagaggtggcccccaccccgctggatgagctccgaggtcac aaggctctggtcaagctccggagccggcaagagcgagacctgcgggagctgcgcaagaag catcagcggaaggcagtcaccctcacccgccgcctgctggatggcctggctcaggcacag gctgagggcaggtgccggctgcggccaggtgccctaggtggggccgctgatgtggaggac acgaaggagggggaggacgaggcaaagcggtatcaggagttccagaacagacaggtgcag agcctgctggagctgcgggaggcccaggtggacgcagaggcccagcggaggctggaacac ctgagacaggctctgcagcggctcagggaggtcgtccttgatgcaaacacaactcagttc aagaggctgaaagagatgaacgagagggagaagaaggagctgcagaagatcctggacaga aagcgccataacagcatctcggaggccaagatgagggacaagcataagaaggaggcggaa ctgacggagattaaccgtcggcacatcactgagtcagtcaactccatccgtcggctggag gaggcccagaagcagcggcatgaccgtcttgtggctgggcagcagcaggtcctgcaacag ctggcagaagaggagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgg gcgaggctcccccaggagatccgccggagcctgctgggcgagatgccggaggggctgggg gacgggcctctggtggcctgtgccagcaacggtcacgcacccgggagcagcgggcacctg tcgggcgctgactcggagagccaggaggagaacacgcagctctga |
Protein Sequence |
>5331 : length: 1234 MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL GSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGH KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG DGPLVACASNGHAPGSSGHLSGADSESQEENTQL |