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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5333 |
Name | PLCD1 |
Synonym | NDNC3|PLC-III;phospholipase C, delta 1;PLCD1;phospholipase C, delta 1 |
Definition | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1|PLC-delta-1|phosphoinositide phospholipase C-delta-1|phospholipase C-III |
Position | 3p22-p21.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
potential | "PLCD1 is silenced by promoter methylation in breast cancer. Silencing of PLCD1 is reversed by demethylation which leads to the disruption of cell cycle at G2/M phase in breast cancer, indicating that PLCD1 functions as a tumor suppressor in this tumor." |
potential | PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis. |
reviewed | Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma. |
| More detail of all 3 literatures about PLCD1 | |
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Pathways and Diseases |
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Pathway | D-myo-inositol (1,4,5)-trisphosphate biosynthesis;BioCyc;PWY-6351 |
Pathway | D-myo-inositol-5-phosphate metabolism;BioCyc;PWY-6367 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | phospholipases;BioCyc;LIPASYN-PWY |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | phospholipase c delta in phospholipid associated cell signaling;PID BioCarta;100071 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Disease | Breast cancer;FunDO |
Disease | Esophagus cancer;FunDO |
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External Links |
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Links to Entrez Gene | 5333 |
Links to all GeneRIF Items | 5333 |
Links to iHOP | 5333 |
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Sequence Information |
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Nucleotide Sequence |
>5333 : length: 2334 atgcagtgcctggggatccggagccggagccgctccagggagctctacctgcaggagcgg agccttaaggtggcggcgctcaatggacggaggctgggcctacaggatgatgaggatcta caggcgctgctgaagggcagccagctcctgaaggtgaagtccagctcatggaggagagag cgcttctacaagttgcaggaggactgcaagaccatctggcaggagtcccgcaaggtcatg cggaccccggagtcccagctgttctccatcgaggacattcaggaggtgcgaatggggcac cgcacggagggtctggagaagttcgcccgtgatgtgcccgaggaccgctgcttctccatt gtcttcaaggaccagcgcaatacactagacctcatcgccccatcgccagctgatgcccag cactgggtgctggggctgcacaagatcatccaccactcaggctccatggaccagcgtcag aagctacagcactggattcactcctgcttgcgaaaagctgacaaaaacaaggacaacaag atgagcttcaaggagctgcagaacttcctgaaggagctcaacatccaggtggacgacagc tatgcccggaagatcttcagggagtgtgaccactcccagacagactccctggaggacgag gagattgaggccttctacaagatgctgacccagcgggtggagatcgaccgcaccttcgcc gaggccgcgggctcaggggagactctgtcggtggatcagttagtgacgttcctgcagcac cagcagcgggaggaggcggcagggcctgcgctggccctctccctcattgagcgctacgag cccagcgagactgccaaggcgcagcggcagatgaccaaggacggcttcctcatgtactta ctgtcggctgacggcagcgccttcagcctggcacaccgccgtgtctaccaggacatgggc cagccacttagccactacctggtgtcctcttcacacaacacctacctgctggaggaccag ctagccgggcccagcagcactgaagcctacatccgggcactgtgcaaaggctgccgatgc ctggagcttgactgctgggacgggcccaaccaggaaccaatcatctaccacggctatact ttcacttccaagatcctcttctgcgatgtgctcagggccatccgggactatgccttcaag gcgtccccctaccctgtcatcctatccctggagaaccactgcacactggagcagcagcgc gtgatggcgcggcacctgcatgccatcctgggccccatgctgttgaaccgaccactggat ggggtcaccaacagcctgccctcccctgagcaactgaaggggaagatcctgctgaagggg aagaagctcggggggctcctgccccctggaggggagggtggccctgaggccactgtggtg tcagacgaagacgaggctgctgagatggaggatgaggcagtgaggagccgtgtgcagcac aagcccaaggaggacaagctcaggctagcacaggagctctctgacatggtcatttactgc aagagtgtccactttgggggcttctccagtcctggcacccctggacaggccttctacgag atggcgtccttctctgagaaccgtgcccttcgactgctccaagaatcaggaaacggcttt gtccgccacaacgtggggcacctgagcagaatctacccggctggatggagaacagactcc tccaactacagccccgtggagatgtggaatgggggctgccagatcgtggccctgaatttc cagacacctgggccagagatggacgtgtaccagggccgcttccaggacaacggggcctgt gggtacgtgctgaagcccgccttcctgcgagaccccaacggcacctttaacccccgcgcc ctggctcaggggccctggtgggcacggaagcggctcaacatcagggtcatttcggggcag cagctgccaaaagtcaacaagaataagaattcaattgtggaccccaaagtgacagtggag atccatggcgtgagccgggacgtggccagccgccagactgctgtcatcaccaacaatggt ttcaacccatggtgggacacggagtttgcgtttgaggtagttgtgcctgaccttgccctc atccgcttcttggtggaagattatgatgcctcctccaagaatgacttcattggccagagt accatccccttgaacagcctcaagcaaggataccgccatgtccacctcatgtctaagaac ggggaccagcatccatcagccaccctctttgtgaagatctccctccaggactag |
Protein Sequence |
>5333 : length: 777 MQCLGIRSRSRSRELYLQERSLKVAALNGRRLGLQDDEDLQALLKGSQLLKVKSSSWRRE RFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSI VFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNK MSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFA EAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYL LSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRC LELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQR VMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVV SDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYE MASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNF QTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQ QLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLAL IRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD |