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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 53353 |
Name | LRP1B |
Synonym | LRP-DIT|LRPDIT;low density lipoprotein receptor-related protein 1B;LRP1B;low density lipoprotein receptor-related protein 1B |
Definition | LRP-1B|LRP-deleted in tumors|low density lipoprotein receptor related protein-deleted in tumor|low density lipoprotein-related protein 1B (deleted in tumors)|low-density lipoprotein receptor-related protein 1B|low-density lipoprotein receptor-related prot |
Position | 2q21.2 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 5 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. |
reviewed | Aberrant methylation impairs low density lipoprotein receptor-related protein 1B tumor suppressor function in gastric cancer. |
potential | The LRP1B gene is a candidate tumor suppressor gene in urothelial cancer. |
potential | "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein." |
potential | "Genomic organization of a new candidate tumor suppressor gene, LRP1B." |
| More detail of all 5 literatures about LRP1B | |
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Pathways and Diseases |
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Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Disease | aging;GAD |
Disease | Erectile dysfunction and prostate cancer treatment;NHGRI |
Disease | Body mass index;NHGRI |
Disease | Aging;NHGRI |
Disease | AGING;GAD |
Disease | Optic disc size (disc);NHGRI |
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External Links |
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Links to Entrez Gene | 53353 |
Links to all GeneRIF Items | 53353 |
Links to iHOP | 53353 |
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Sequence Information |
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Nucleotide Sequence |
>53353 : length: 13800 atgtccgagtttctcctcgccttactcactctctcgggattattgccgattgccagggtg ctgaccgtgggagccgaccgagatcagcagttgtgtgatcctggtgaatttctttgccac gatcacgtgacttgtgtctcccagagctggctgtgtgatggggaccctgactgccctgat gattcagacgagtctttagatacctgtcccgaggaggtagaaatcaagtgccccttgaat cacattgcttgccttggtaccaacaaatgtgttcatttatcccagctgtgcaatggtgtc ttggactgcccagatgggtatgacgaaggagtacattgtcaggaactgttatccaattgc caacagctgaattgtcagtataaatgtacaatggtcagaaatagtacaagatgttactgt gaggatggattcgaaataacagaagatgggagaagctgtaaagatcaagatgaatgtgct gtttatggtacatgcagccagacctgcagaaacacacatggatcctacacttgcagttgt gtggaaggctacctaatgcagccagacaacagatcttgcaaggctaaaattgaacctaca gatagaccacctatactattaattgcaaattttgaaacaattgaggttttctatcttaat ggaagtaaaatggcaactctaagctcagtcaatggaaatgaaattcatactctggatttt atttataatgaagatatgatttgttggattgaatcaagagaatcttcaaatcaactcaaa tgtatccagataacaaaagcaggaggattaacagatgaatggacaatcaatattcttcaa tccttccacaatgtgcaacaaatggcgattgactggctcactcgaaatctctattttgtg gaccatgtcggtgaccggatctttgtttgtaattccaacggttctgtatgtgtcaccctg attgatctggagcttcacaatcctaaagcaatagcagtagatccaatagcaggaaaactt ttctttactgactacgggaatgtcgccaaagtggagagatgtgacatggatgggatgaac cgaacaaggataattgattcaaagacagagcagccagctgcactggcactagacctagtc aacaaattggtttactgggtagatctttacttggactatgtgggagtagtggactatcaa ggaaaaaatagacacactgtcattcaaggcagacaagttagacatctttatggtataact gtgtttgaagattatttgtatgcaaccaattctgataactacaatatcgtaaggataaac cgatttaatgggactgatattcactcattaattaaaattgagaatgcttggggaatccga atttatcaaaaaagaactcaaccaacagtcagaagccatgcatgtgaagtcgatccatat ggaatgccagggggctgttcacacatctgtctactcagcagcagttacaaaactcggact tgtcgctgcaggactggcttcaacttgggaagtgatggcaggtcatgcaaaagaccaaag aatgagttgttcctcttttatgggaaaggacgcccaggaattgttagaggaatggacttg aataccaagatagctgatgaatacatgatccccatagaaaatctggtaaaccctcgtgct ttagactttcacgcagaaaccaattacatctactttgctgacaccaccagtttcctaatt ggccggcagaagatagatggcacagagagagaaaccatcctgaaagatgatctggataat gtagagggcattgctgtggactggattggaaataatctttactggaccaatgatggccat aggaaaaccattaatgtggccaggctggaaaaagcttctcagagtcggaagactctttta gagggtgaaatgtctcatcccagaggaattgtggtggatccagttaatggttggatgtat tggacagactgggaggaagatgaaatagatgacagcgtgggaaggattgagaaggcctgg atggatggattcaatcggcagatttttgtgacttcaaagatgctgtggccaaacggttta actctggactttcacaccaacacattatactggtgtgatgcctattacgatcatattgaa aaagtatttttgaatgggactcacaggaagattgtttacagtgggagagagttgaaccac cctttcggactgtcgcatcatggaaattatgtgttctggactgattatatgaatggttcc atttttcaactagatttgataacaagtgaggtgacattgctgaggcatgaaagaccaccc ctatttgggcttcagatttatgatccacgaaagcaacaaggtgacaatatgtgccgagta aataatgggggctgtagtacactttgcttggctatcccaggaggccgggtgtgtgcttgt gccgataatcaacttttggatgaaaatgggacaacttgcacatttaatcctggagaagca ctacctcacatatgtaaagctggagagtttcgctgcaaaaacagacactgtatccaagct cggtggaaatgtgatggcgacgatgactgcctagacggaagcgatgaggattcagtaaac tgcttcaatcatagctgtcctgatgatcagtttaaatgccagaataatcgctgcatcccc aagagatggctttgtgatggagctaatgactgtgggagcaatgaagatgaatccaatcaa acttgcacagccagaacatgccaggtagaccagttttcttgcggaaatgggcgttgcatt cccagagcatggctgtgtgacagggaagacgactgtggtgaccagacagatgaaatggca tcttgtgaattcccaacttgtgagccactaacccaattcgtatgcaaaagtggaagatgc attagcagcaaatggcactgcgactctgatgacgactgtggggacgggagtgatgaggtg ggctgtgttcactcttgctttgataatcagttcagatgttccagtggcagatgcatccca ggccactgggcctgtgatggtgacaatgactgtggggacttcagtgatgaagcccagatc aattgtactaaagaagagattcattctcctgctggttgtaacggaaatgaatttcagtgc caccctgatggtaattgcgttcctgatttgtggcgctgtgatggagaaaaagactgtgaa gatggtagtgatgaaaaaggttgcaatggtaccatacgattgtgtgaccacaaaaccaag ttttcctgttggagtacagggagatgcatcaacaaagcatgggtgtgtgatggagatatt gattgcgaagatcagtcagatgaagatgactgtgacagtttcttgtgtggaccacccaag catccttgtgctaatgacacctcagtctgcctgcagccagagaaactctgcaatgggaaa aaggattgtcctgatggctctgatgaaggctatctctgtgatgagtgttcgctgaacaat ggaggctgtagcaaccactgttctgttgttcctggaagaggaattgtctgttcctgccct gaaggacttcaactcaacaaagacaataaaacatgtgaaattgtggattattgtagcaat catctaaagtgcagccaagtatgtgagcagcacaagcacacagtcaagtgctcatgttat gaaggttggaagctggatgtagacggtgaaagttgtacaagtgttgatccttttgaagca ttcatcatcttttctattcgtcatgagatcagaaggattgatcttcacaaaagagactat agtctacttgttcctggattgagaaacacaatagcacttgattttcacttcaatcaaagt ttactttattggacagatgttgtagaagacagaatataccggggaaagctttctgaaagt ggaggtgtcagtgccattgaagtggttgtggagcatggcctggctactccagaaggcctg acagtcgactggatagcaggaaacatatactggatagacagcaatctggaccaaatcgaa gtggccaaactagatggctccctaagaactacactaatagcaggagccatggaacacccc agggccattgctttggacccaagatatggaattcttttctggacagactgggatgcaaat tttcctcgcattgaatctgcctctatgagtggtgctgggagaaaaaccatctataaagac atgaaaactggggcttggcctaatggactaactgtggaccactttgagaaaaggatagtg tggacagacgccaggtcagatgctatttattcagccctctatgatggaacaaacatgata gaaatcatccgaggtcatgaatacctttcccatccctttgctgtgtctctatatgggagt gaagtctactggacagactggaggaccaacacattgtccaaagccaataagtggacaggg cagaatgtcagtgtgattcagaaaaccagtgcacagccatttgaccttcagatataccat cccagtcgccagccacaggctcccaatccttgtgcagctaatgatggcaaaggcccctgc tctcacatgtgtctaatcaatcacaataggagtgctgcctgtgcgtgcccccacttgatg aagctttcttcagacaagaagacctgctatgaaatgaaaaaatttcttctttatgcaaga cgttctgaaatcagaggagtggatattgacaatccatactttaacttcatcacggcattt acagtccctgatattgatgacgttactgtgatagacttcgatgcatctgaggaacgttta tactggacagatattaaaacacaaaccattaaacgagcttttattaacggaactgggtta gaaactgttatttcaagagatattcagagtatcagagggctagcagtggattgggtgtca cgtaatttatactggattagctcagaatttgatgaaacgcaaattaatgtggcaaggcta gatggctctttgaaaacctcaattatccatggaatcgataagccacagtgtcttgcagct cacccagtcaggggaaaactctactggaccgatggaaacacaattaacatggcaaatatg gatggcagtaatagcaagattctgtttcagaatcagaaggagccagttggtctatcgata gactatgtggaaaacaagctttattggatcagttcagggaatggaaccataaatagatgc aacctggatggtggtaatttagaagtaatcgagtcaatgaaagaagaattaacaaaagct acagccctaaccatcatggataagaaactgtggtgggcagaccaaaacttagcccagcta ggaacctgcagcaaaagagacggaagaaaccccaccatcctacggaataagacttctggg gtagttcatatgaaagtctatgataaagaagcacagcaaggcagcaattcctgccaacta aacaatggtggatgctctcaactttgtttaccaacatctgaaactacaaggacttgtatg tgtacagtgggatattatctccaaaagaaccgtatgtcatgtcaaggtatagaatcattt cttatgtactctgttcatgaaggaatcaggggaatacctcttgaaccaagtgacaaaatg gatgctttgatgcctatatcaggaacttcatttgccgtgggaatagatttccatgcagaa aatgataccatctactggacagacatgggcttcaataaaattagcagagctaaaagagat cagacttggaaagaagatatcattaccaatggcttgggaagagtggaagggatagctgtt gactggattgctggtaacatatattggacagatcatggtttcaacttaattgaagttgca agactcaatggttctttccgttatgtaattatttcccaaggcctggatcaaccaagatct atagctgtgcacccagagaaaggcctcttgttctggactgaatggggacaaatgccctgt attggaaaggctcgcttggatggctcagagaaggttgtccttgtaagcatgggaatagca tggccgaatggcatctccatcgactatgaggaaaataaattgtactggtgtgatgctcgc acagacaagatagagagaatcgaccttgagactggagggaatcgcgagatggtgctgtca ggaagcaatgtggatatgttttcagttgcagtctttggggcttacatctactggtctgac agagcacatgcaaacgggtctgtcagaaggggccacaagaatgatgccacagaaacgata accatgagaaccggccttggagtcaacctgaaggaggttaaaatatttaaccgagtaaga gagaaagggaccaatgtttgtgccagggacaatggtggctgtaagcaactctgtctttat cgaggaaattcccggagaacttgtgcttgtgcccatggatatttggcagaagatggagtt acttgcctgaggcatgaaggctatttactgtattcaggaagaacaatattaaaaagtata catctttctgatgaaaccaatttaaattccccaataaggccatatgagaatccacgttat ttcaagaatgtcatagccttggcttttgactataatcaaagaagaaaaggtaccaaccga atcttttacagtgatgcacactttggaaatatacagcttattaaagacaactgggaagac agacaagtaattgttgaaaatgtgggttctgtggaaggacttgcctatcacagagcctgg gatacactgtactggacaagctctaccacctcatccatcaccagacacactgtggaccag actcggcctggagcatttgacagggaagctgtcatcaccatgtcagaagatgaccatcca catgtgctagccttggatgaatgtcaaaatttaatgttttggaccaactggaatgaacaa catccaagtatcatgagatctactctgactgggaaaaatgctcaagtggtggtcagtaca gacatactcactccaaatggacttactatcgactaccgtgcagagaagctgtatttctca gatggcagtctaggaaaaattgaaaggtgtgaatacgatggatcccagagacatgtgata gttaaatctgggccagggactttcctcagtttggctgtttatgacaattatatattctgg tcggactggggaagaagagctatactgcggtccaacaagtacacaggaggagatacaaaa attcttcgttccgatattccacatcagccaatgggaatcatagctgttgccaatgacacc aatagctgtgaactttctccatgtgcattattgaatggaggctgccatgacttgtgcctt ttaactcccaatgggagagtgaattgttcctgcagaggggaccgaatattgctagaggac aacagatgtgtgactaaaaattcctcctgcaacgcttattcggagtttgaatgtggaaat ggtgagtgcattgactaccagctcacctgtgatggcattcctcactgtaaagataaatca gatgaaaaactgctctactgtgaaaacagaagctgtcgaagaggcttcaagccatgctat aatcgccgctgcattcctcatggcaagttatgtgatggagaaaatgactgcggagacaac tctgatgaattagattgtaaagtttcaacctgtgccacggttgagttccgctgtgcagat gggacttgtattccaagatcagcacgatgcaaccagaacatagattgtgcagatgcttca gatgaaaagaactgcaataacacagactgcacacatttctataagcttggagtgaaaacc acagggttcataagatgtaattctacctcactgtgtgttctgccaacctggatatgcgac gggtctaatgactgtggagactattcagatgaattaaagtgcccagttcaaaacaaacac aaatgtgaagaaaattattttagttgtcctagtggaagatgcattttgaatacctggata tgcgatggtcagaaagattgtgaggatggacgtgatgaattccactgtgattcttcttgc tcttggaaccaatttgcttgttccgcacaaaaatgtatttctaagcattggatttgtgat ggagaagatgactgtggggatgggttagatgaaagtgacagcatttgtggtgccataacc tgtgctgctgacatgttcagctgccagggctctcgtgcctgcgtgccccgacattggctt tgtgatggtgaaagggactgtccagatggaagcgatgagctttccacagcaggctgcgct cccaataatacatgtgatgaaaatgctttcatgtgccataataaagtatgcattcccaag caatttgtttgtgaccatgatgacgactgtggagatggctctgatgagtcaccgcagtgt ggatatcgacagtgtggtacagaagaatttagttgtgctgatgggcggtgtcttctaaat actcaatggcagtgtgatggagactttgactgtcctgaccattctgatgaagcaccttta aacccaaagtgtaaaagtgcagaacagtcatgcaacagttcattttttatgtgcaaaaat ggcaggtgcattcccagtggaggtctttgcgacaataaggatgactgtggcgatggttca gatgagagaaactgccatataaatgaatgtttgagtaagaaagtcagtggatgttctcaa gactgtcaagaccttccggtcagttataagtgcaaatgctggcctggattccaactgaag gatgacggcaaaacatgtgtagacattgatgaatgctcttcaggctttccctgtagccag caatgcatcaatacatacgggacttacaagtgcctctgtacagatgggtatgaaatacaa cctgataacccaaatggctgcaaatcgctctcagatgaagaaccttttttaattcttgct gatcatcatgagataaggaaaattagcactgatggctccaactacacacttttaaaacag ggattaaacaatgttattgctatagactttgattacagagaagaattcatctattggatc gattctagccgacccaatggcagtcgcataaatagaatgtgtttaaatggaagtgacatt aaggtagttcataacacagcggtccccaatgcacttgctgtcgattggattggaaaaaac ctctattggtctgacacagaaaaaagaatcattgaagtatccaaactcaatggcttgtac cctactatactcgttagcaaaaggctgaagtttcccagagacttgtctttagatcctcaa gctggatatttgtattggattgactgctgcgagtatcctcatattggccgtgttggaatg gatggaaccaatcagagtgttgtcatagaaaccaagatttctagacctatggcactaaca atagattatgttaatcgtagactctactgggccgatgaaaatcacattgaatttagcaac atggatggatctcatagacacaaagtccctaatcaagatattccaggggtgattgcacta acattgtttgaagactacatctactggactgatgggaaaaccaagtcactcagccgtgcc cataaaacatcgggagcagacagactctcactgatttactcatggcatgccatcacagat atccaggtgtatcattcttatagacaacctgatgtctccaaacatctctgcatgataaat aatggtggttgcagtcatttgtgccttttagcccctggaaaaacccacacttgtgcatgt cccactaacttctatctggcagctgataataggacttgcttatccaactgcacagccagc cagtttcgttgcaaaactgacaaatgtattccattctggtggaaatgtgacaccgtggat gactgtggtgatggatctgatgaacctgatgactgtcctgaatttagatgtcagccaggc cgatttcagtgtgggactggactctgtgctctaccagctttcatctgtgatggagagaat gattgtggagacaattctgatgaactcaactgtgacacacatgtctgcctgtcaggtcaa ttcaaatgtaccaagaaccagaaatgtatcccagtaaacttaagatgtaatgggcaagat gactgtggtgatgaggaagatgaaagagactgtcctgaaaacagctgttctccagactat ttccagtgtaagactacgaagcattgcatttccaagctgtgggtttgtgacgaggatcca gactgtgcagatgcatcagacgaggccaactgcgataaaaagacttgtggacctcatgaa ttccagtgtaaaaacaacaactgtattcccgatcactggcggtgtgatagccaaaatgac tgcagtgataattcagatgaagaaaactgtaagccacagacatgtacattgaaagatttc ctctgtgccaatggggactgtgtttcttcaaggttttggtgtgatggagattttgactgt gcagatggctctgatgagagaaattgtgagacaagttgttccaaagatcagttccggtgt tccaatggtcagtgtataccagcaaaatggaaatgtgatggccatgaagactgcaaatat ggggaagatgagaaaagctgtgagccagcttctcctacttgctcatcacgtgaatatata tgtgccagtgatggatgtatttcagcatctttgaaatgtaatggagaatatgattgtgct gatggttcagatgagatggactgtgtgactgaatgtaaggaagatcagtttcggtgcaaa aataaagcccactgtattccaattagatggctgtgtgatggaattcatgactgtgtggat ggcagtgatgaagagaactgtgaaagaggaggaaatatatgtagagctgatgagttcctt tgcaataattctctctgcaaactacatttctgggtgtgtgatggagaggacgactgtgga gacaactctgatgaagcccctgatatgtgtgtcaaatttctttgtccatccacgagacct cacagatgcagaaataacagaatatgcctacagtcggagcaaatgtgcaatgggattgat gaatgcggtgacaattcagatgaagatcactgtggtggtaagctgacatataaagcaagg ccttgtaaaaaggatgagtttgcttgtagtaataaaaaatgcatccctatggatctccag tgtgatcgacttgatgactgcggagatggttcagatgagcaaggatgcagaatagctcct actgaatatacctgtgaagataatgtgaatccatgtggagatgatgcatattgtaatcaa ataaaaacatctgttttctgtcgctgtaagcctggatttcagagaaacatgaaaaacaga caatgtgaagaccttaatgaatgtttggtgtttggcacatgttcccatcaatgtataaat gtggaaggatcatataaatgtgtgtgtgaccagaattttcaagaaagaaataacacctgc atagcagaaggctctgaagatcaagttctctacattgctaatgacactgatatcctgggt tttatatatccattcaactacagtggcgatcatcaacaaatttctcatattgaacataat tcaagaataacagggatggatgtatattatcaaagagatatgattatttggagtactcag tttaatccaggcggaattttctacaaaaggatccatggcagagaaaaaaggcaagcaaac agtggcttgatttgtcctgaatttaaaaggcccagggacattgcagttgactgggtggct ggaaacatttactggactgatcattctagaatgcattggttcagttactacactactcac tggaccagtctgaggtactctatcaacgtagggcagctgaatggccccaactgcaccaga ctcttaacaaatatggctggagaaccctatgctattgcagtaaatcctaaaagagggatg atgtactggactgttgttggggatcattcccatatagaagaagcagccatggatggtaca ctgagaaggattttagtacaaaagaacttacagagacccacaggtttggctgtggattat tttagtgaacgcatatattgggctgactttgagctctccatcattggcagtgttctgtat gatggctctaattcagtagtctctgtcagcagcaaacaaggtttattacatccacatagg atcgatatctttgaagattatatatatggagcaggacctaaaaatggtgtatttcgagtt caaaaatttggccatggttcagtagagtacttagctttaaatattgataaaacaaaaggt gttttgatatctcatcgttataaacaactagatttacccaatccatgcttggatttagca tgcgaatttctttgcttgctaaatccttctggggccacttgtgtgtgtccagaaggaaaa tatttgattaatggcacctgcaatgatgacagcctgttagatgattcatgtaagttaact tgtgaaaatggaggaagatgcattttaaatgagaaaggtgatttgaggtgtcactgttgg cccagttattcaggagaaagatgtgaagtcaaccactgtagcaactactgccagaatgga ggaacttgcgtaccatcagttctagggagacccacctgcagctgtgcactgggtttcact gggccaaactgtggtaagacagtctgtgaggatttttgtcaaaatggaggaacctgcatt gtgactgctggaaaccagccttactgccactgccagccggaatacaccggagacagatgt cagtactacgtgtgccaccactattgtgtgaattctgaatcatgtaccattggggatgat ggaagtgttgaatgtgtctgtccaacgcgctatgaaggaccaaaatgtgaggttgacaag tgtgtaaggtgccatggggggcactgcattataaataaagacagtgaagatatattttgc aactgcactaatggaaagattgcctctagctgtcagttatgtgatggctactgttacaat ggtggcacatgccagctggaccccgagacaaatgtacctgtgtgtctatgctccaccaac tggtcaggcacacagtgtgaaaggccagccccaaagagcagcaagtctgatcatatcagc acaagaagcattgccatcattgtgcctctcgtcctcttggtgactttgataaccacctta gtaattggtttagtgctttgtaaaagaaaaagaaggacaaaaacaattagaagacaacct attatcaatggaggaataaatgtagaaattggcaatccatcttataacatgtatgaggta gatcatgatcacaacgatggaggtcttttagatcctggctttatgatagacccaacaaag gccaggtacatagggggaggacccagtgctttcaagcttccacacacagcgccgcccatc tacctaaactctgatttgaaaggaccactaactgctgggccaacaaattactccaatccg gtatatgcaaaattatatatggatgggcaaaactgtcgaaactccttaggaagtgttgat gaaaggaaagaactgcttccaaagaaaatagaaattggtataagagagacagtggcataa |
Protein Sequence |
>53353 : length: 4599 MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPD DSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNC QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSC VEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDF IYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFV DHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMN RTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGIT VFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPY GMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDL NTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDN VEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMY WTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIE KVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPP LFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEA LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIP KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMA SCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIP GHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK HPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCP EGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEA FIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHP RAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIV WTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTG QNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM KLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERL YWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARL DGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSI DYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQL GTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCM CTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAE NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA WPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLY RGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRY FKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAW DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT NSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGN GECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDN SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKT TGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWI CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK QFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPL NPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQ DCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQ PDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWI DSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLY PTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALT IDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRA HKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCAC PTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPG RFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQD DCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHE FQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDC ADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYI CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD GSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRP HRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQ CDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNR QCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILG FIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQAN SGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTR LLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDY FSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRV QKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGK YLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNG GTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRC QYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFC NCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHIS TRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEV DHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNP VYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA |