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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 54583 |
Name | EGLN1 |
Synonym | C1orf12|ECYT3|HIF-PH2|HIFPH2|HPH-2|HPH2|PHD2|SM20|ZMYND6;egl nine homolog 1 (C. elegans);EGLN1;egl nine homolog 1 (C. elegans) |
Definition | HIF prolyl hydroxylase 2|HIF-prolyl hydroxylase 2|egl nine homolog 1|egl nine-like protein 1|hypoxia-inducible factor prolyl hydroxylase 2|prolyl hydroxylase domain-containing protein 2|zinc finger MYND domain-containing protein 6 |
Position | 1q42.1 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | Data suggest that PHD2/HIF-2/amphiregulin signaling has a critical role in the regulation of breast tumor progression and propose PHD2 as a potential tumor suppressor in breast cancer. |
potential | "EGLN1 can be considered as a candidate tumor suppressor on chromosome 1q, and our observation could open the new aspect in exploring the machinery of senescence induction associated with hypoxia-inducible factor 1, alpha signal transduction". |
| More detail of all 2 literatures about EGLN1 | |
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Pathways and Diseases |
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Pathway | Hypoxia response via HIF activation;PANTHER;P00030 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | Congenital polycythemia;KEGG DISEASE;H00236 |
Disease | Erythrocytosis, familial, 3;OMIM |
Disease | Circulatory system diseases;KEGG DISEASE |
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External Links |
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Links to Entrez Gene | 54583 |
Links to all GeneRIF Items | 54583 |
Links to iHOP | 54583 |
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Sequence Information |
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Nucleotide Sequence |
>54583 : length: 1281 atggccaatgacagcggcgggcccggcgggccgagcccgagcgagcgagaccggcagtac tgcgagctgtgcgggaagatggagaacctgctgcgctgcagccgctgccgcagctccttc tactgctgcaaggagcaccagcgtcaggactggaagaagcacaagctcgtgtgccagggc agcgagggcgccctcggccacggagtgggcccacaccagcattccggccccgcgccgccg gctgcagtgccgccgcccagggccggggcccgggagcccaggaaggcagcggcgcgccgg gacaacgcctccggggacgcggccaagggaaaagtaaaggccaagcccccggccgaccca gcggcggccgcgtcgccgtgtcgtgcggccgccggcggccagggctcggcggtggctgcc gaagccgagcccggcaaggaggagccgccggcccgctcatcgctgttccaggagaaggcg aacctgtaccccccaagcaacacgcccggggatgcgctgagccccggcggcggcctgcgg cccaacgggcagacgaagcccctgccggcgctgaagctggcgctcgagtacatcgtgccg tgcatgaacaagcacggcatctgtgtggtggacgacttcctcggcaaggagaccggacag cagatcggcgacgaggtgcgcgccctgcacgacaccgggaagttcacggacgggcagctg gtcagccagaagagtgactcgtccaaggacatccgaggcgataagatcacctggatcgag ggcaaggagcccggctgcgaaaccattgggctgctcatgagcagcatggacgacctgata cgccactgtaacgggaagctgggcagctacaaaatcaatggccggacgaaagccatggtt gcttgttatccgggcaatggaacgggttatgtacgtcatgttgataatccaaatggagat ggaagatgtgtgacatgtatatattatcttaataaagactgggatgccaaggtaagtgga ggtatacttcgaatttttccagaaggcaaagcccagtttgctgacattgaacccaaattt gatagactgctgtttttctggtctgaccgtcgcaaccctcatgaagtacaaccagcatat gctacaaggtacgcaataactgtttggtattttgatgcagatgagagagcacgagctaaa gtaaaatatctaacaggtgaaaaaggtgtgagggttgaactcaataaaccttcagattcg gtcggtaaagacgtcttctag |
Protein Sequence |
>54583 : length: 426 MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS VGKDVF |