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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 54984 |
Name | PINX1 |
Synonym | LPTL|LPTS;PIN2/TERF1 interacting, telomerase inhibitor 1;PINX1;PIN2/TERF1 interacting, telomerase inhibitor 1 |
Definition | 67-11-3 protein|PIN2 interacting protein 1|PIN2-interacting protein 1|PIN2/TERF1-interacting telomerase inhibitor 1|TRF1-interacting protein 1|hepatocellular carcinoma-related putative tumor suppressor|liver-related putative tumor suppressor|pin2-interact |
Position | 8p23 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,Generif,UniProt |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
reviewed | The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. |
potential | Data show that liver-related putative tumor suppressor gene (LPTS) mutations occur in hepatocellular carcinoma but are infrequent and of little effect on the telomerase inhibitory function of the protein. |
potential | Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma. |
| More detail of all 3 literatures about PINX1 | |
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Pathways and Diseases |
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Pathway | Regulation of Telomerase;PID Curated;200072 |
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External Links |
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Links to Entrez Gene | 54984 |
Links to all GeneRIF Items | 54984 |
Links to iHOP | 54984 |
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Sequence Information |
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Nucleotide Sequence |
>54984 : length: 987 atgtctatgctggctgaacgtcggcggaagcagaagtgggctgtggatcctcagaacact gcctggagtaatgacgattccaagtttggccagcggatgctagagaagatggggtggtct aaaggaaagggtttaggggctcaggagcaaggagccacagatcatattaaagttcaagtg aaaaataaccacctgggactcggagctaccatcaataatgaagacaactggattgcccat caggatgattttaaccagcttctggccgaactgaacacttgccatgggcaggaaaccaca gattcctcggacaagaaggaaaagaaatcttttagccttgaggaaaagtccaaaatctcc aaaaaccgtgttcactatatgaaattcacaaaagggaaggatctgtcatctcggagcaaa acagatcttgactgcatttttgggaaaagacagagtaagaagactcccgagggcgatgcc agtccctccactccagaggagaacgaaaccacgacaaccagcgccttcaccatccaggag tactttgccaagcggatggcagcactgaagaacaagccccaggttccagttccagggtct gacatttctgagacgcaggtggaacgtaaaagggggaagaaaagaaataaagaggccaca ggtaaagatgtggaaagttacctccagcctaaggccaagaggcacacggagggaaagccc gagagggccgaggcccaggagcgagtggccaagaagaagagcgcgccagcagaagagcag ctcagaggcccctgctgggaccagagttccaaggcctctgctcaggatgcaggggaccat gtgcagccgcctgagggccgggacttcaccctgaagcccaaaaagaggagagggaagaaa aagctgcaaaaaccagtagagatagcagaggacgctacactagaagaaacgctagtgaaa aagaagaagaagaaagattccaaatga |
Protein Sequence |
>54984 : length: 328 MSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQV KNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKIS KNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQE YFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKP ERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKK KLQKPVEIAEDATLEETLVKKKKKKDSK |