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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5499 |
Name | PPP1CA |
Synonym | PP-1A|PP1alpha|PPP1A;protein phosphatase 1, catalytic subunit, alpha isozyme;PPP1CA;protein phosphatase 1, catalytic subunit, alpha isozyme |
Definition | protein phosphatase 1, catalytic subunit, alpha isoform|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit|serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
Position | 11q13 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | "PPP1CA contributes to the senescence program induced by oncogenic Ras. We propose that oncogenic stress induced by ras causes ceramide accumulation, therefore, increasing PPP1CA activity, pRb dephosphorylation and onset of the p53-induced arrest, contributing to tumor suppression." |
| More detail of all 1 literatures about PPP1CA | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | BMP receptor signaling;PID Curated;200123 |
Pathway | protein kinase a at the centrosome;PID BioCarta;100246 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | ALK1 signaling events;PID Curated;200126 |
Pathway | DARPP-32 events;PID Reactome;500841 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | regulation of ck1/cdk5 by type 1 glutamate receptors;PID BioCarta;100201 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
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External Links |
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Links to Entrez Gene | 5499 |
Links to all GeneRIF Items | 5499 |
Links to iHOP | 5499 |
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Sequence Information |
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Nucleotide Sequence |
>5499 : length: 1026 atgtccgacagcgagaagctcaacctggactcgatcatcgggcgcctgctggaagggtcc agggtcctgacaccccattgcgccccagtgcagggctcgcggcctggcaagaatgtacag ctgacagagaacgagatccgcggtctgtgcctgaaatcccgggagatttttctgagccag cccattcttctggagctggaggcacccctcaagatctgcggtgacatacacggccagtac tacgaccttctgcgactatttgagtatggcggtttccctcccgagagcaactacctcttt ctgggggactatgtggacaggggcaagcagtccttggagaccatctgcctgctgctggcc tataagatcaagtaccccgagaacttcttcctgctccgtgggaaccacgagtgtgccagc atcaaccgcatctatggtttctacgatgagtgcaagagacgctacaacatcaaactgtgg aaaaccttcactgactgcttcaactgcctgcccatcgcggccatagtggacgaaaagatc ttctgctgccacggaggcctgtccccggacctgcagtctatggagcagattcggcggatc atgcggcccacagatgtgcctgaccagggcctgctgtgtgacctgctgtggtctgaccct gacaaggacgtgcagggctggggcgagaacgaccgtggcgtctcttttacctttggagcc gaggtggtggccaagttcctccacaagcacgacttggacctcatctgccgagcacaccag gtggtagaagacggctacgagttctttgccaagcggcagctggtgacacttttctcagct cccaactactgtggcgagtttgacaatgctggcgccatgatgagtgtggacgagaccctc atgtgctctttccagatcctcaagcccgccgacaagaacaaggggaagtacgggcagttc agtggcctgaaccctggaggccgacccatcaccccaccccgcaattccgccaaagccaag aaatag |
Protein Sequence |
>5499 : length: 341 MSDSEKLNLDSIIGRLLEGSRVLTPHCAPVQGSRPGKNVQLTENEIRGLCLKSREIFLSQ PILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLA YKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKI FCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGA EVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETL MCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK |