|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5519 |
Name | PPP2R1B |
Synonym | PP2A-Abeta|PR65B;protein phosphatase 2, regulatory subunit A, beta;PPP2R1B;protein phosphatase 2, regulatory subunit A, beta |
Definition | PP2A, subunit A, PR65-beta isoform|PP2A, subunit A, R1-beta isoform|protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform|protein phosphatase 2, structural/regulatory subunit A, beta|serine/threonine-protein phosphatase 2A 65 kDa regulat |
Position | 11q23.2 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 2 PubMed records as below. |
|
Evidence Status |
Description |
potential | These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. |
reviewed | Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. |
| More detail of all 2 literatures about PPP2R1B | |
|
Pathways and Diseases |
|
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | DNA Replication;Reactome;REACT:383 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Signaling by Wnt;Reactome;REACT:11045 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Metabolism of carbohydrates;Reactome;REACT:474 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Disease | Lung cancer;OMIM |
|
External Links |
|
Links to Entrez Gene | 5519 |
Links to all GeneRIF Items | 5519 |
Links to iHOP | 5519 |
|
Sequence Information |
|
Nucleotide Sequence |
>5519 : length: 1671 atggcgggcgcatcagagctcgggaccggcccaggagcagcgggtggagatggagatgat tcgctatacccgatcgcggttttaatcgacgagctccgcaatgaagacgtgcagctccga ctcaacagtattaagaagttatcaacaattgccctagcacttggagtagaaaggacccga agtgaattgttgccatttcttacagatacaatttatgatgaagatgaggtactattagct cttgctgagcagctgggaaatttcactggcctagtgggaggtcctgactttgcccactgt ctgctgcctcctttggaaaatctggcaactgtggaagagactgttgttcgtgacaaggct gtggagtccctgagacagatctcccaggagcatactcctgttgctctggaagcttatttt gtacctctggtgaaacgcttagcaagtggggattggttcacctctcgcacatctgcatgt ggtttgttcagcgtttgctatcccagggcatcaaatgctgttaaagcagaaatcagacag caattccgttccttgtgctcagatgacacaccaatggtacgacgtgctgctgcttccaaa ttgggtgaatttgcaaaagttttggaattagacagtgtgaaaagtgaaattgttccactg ttcactagtctagcttcagatgaacaggattcagtgcgcctccttgctgtggaagcttgt gtcagtattgcccagttattgtctcaggatgaccttgagactttggtgatgcctacactt cgacaagcagcagaagataaatcttggcgcgttcgctatatggtggctgacagattttca gagctccagaaagccatgggtcctaaaatcaccctaaatgacctcatccccgcctttcag aacctacttaaagactgtgaagctgaagtccgggcagctgctgcccacaaagtaaaagaa cttggtgagaacttgcccattgaagatagagagaccataattatgaatcaaattctgcct tatataaagtgtcctgacgttcgtttgaatatcatctccaatttggattgtgtaaatgaa gtgattggaatccgtcagctctctcagtctctccttcctgccatagtggagctggcagaa gatgccaaatggagggtccgcctggccatcattgagtatatgccgctgctggcaggccag ctgggtgtggaattctttgatgaaaagctgaattctttatgtatggcttggctcgtggac catgtatacgccatccgagaagctgccaccaacaacctcatgaaactagttcagaagttt ggtacagagtgggcccaaaatactattgttcccaaagtgttagtaatggcaaatgatcct aattacttgcatagaatgaccactttattctgcattaatgcactgtctgaggcctgtggt caggaaataactactaagcaaatgctgcccatcgtattaaaaatggcaggagaccaagta gcaaatgttcgcttcaatgtggccaaatctctacaaaagattggaccaattctagatacc aatgctttacagggagaagtgaagccagtactacagaagttaggtcaagatgaagacatg gatgtcaaatactttgcacaggaagctataagtgttcttgcattggcataa |
Protein Sequence |
>5519 : length: 556 MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKCPDVRLNIISNLDCVNE VIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVD HVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACG QEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDM DVKYFAQEAISVLALA |