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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5625 |
Name | PRODH |
Synonym | HSPOX2|PIG6|POX|PRODH1|PRODH2|SCZD4|TP53I6;proline dehydrogenase (oxidase) 1;PRODH;proline dehydrogenase (oxidase) 1 |
Definition | p53-induced gene 6 protein|proline dehydrogenase 1, mitochondrial|proline dehydrogenase, mitochondrial|proline oxidase 2|proline oxidase, mitochondrial|tumor protein p53 inducible protein 6 |
Position | 22q11.21 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer." |
potential | POX is a mitochondrial tumor suppressor and a potential target for cancer therapy. |
| More detail of all 2 literatures about PRODH | |
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Pathways and Diseases |
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Pathway | citrulline biosynthesis;BioCyc;CITRULBIO-PWY |
Pathway | proline degradation;BioCyc;PROUT-PWY |
Pathway | Arginine and proline metabolism;KEGG PATHWAY;hsa00330 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Metabolism of amino acids and derivatives;Reactome;REACT:13 |
Pathway | superpathway of citrulline metabolism;BioCyc;PWY-5004 |
Pathway | Proline catabolism;PID Reactome;500951 |
Pathway | Huntington disease;PANTHER;P00029 |
Disease | Hyperprolinemia;KEGG DISEASE;H00190 |
Disease | PSYCH;GAD |
Disease | Genetic disorders;KEGG DISEASE |
Disease | Hyperprolinemia, type I;OMIM |
Disease | Inherited disorders of amino acid metabolism;KEGG DISEASE |
Disease | schizophrenia;GAD |
Disease | CATCH 22 syndrome;GAD |
Disease | Schizophrenia, susceptibility to, 4;OMIM |
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External Links |
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Links to Entrez Gene | 5625 |
Links to all GeneRIF Items | 5625 |
Links to iHOP | 5625 |
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Sequence Information |
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Nucleotide Sequence |
>5625 : length: 1479 atgaagatgaccttctatgggcattttgtagccggggaggaccaggagtccatccagccc ctgcttcggcactacagggccttcggtgtcagcgccatcctggactatggagtggaggag gacctgagccccgaggaggcagagcacaaggagatggagtcctgcacctcagctgcggag agggatggcagtggcacgaataagcgggacaagcaataccaggcccaccgggccttcggg gaccgcaggaatggtgtcatcagtgcccgcacctacttctacgccaatgaggccaagtgc gacagccacatggagacattcttgcgctgcatcgaagcctcaggtagagtcagcgatgac ggcttcatagccattaagctcacagcactggggagaccccagtttctgctgcagttctca gaggtgctggccaagtggaggtgcttctttcaccaaatggctgtggagcaagggcaggcg ggcctggctgccatggacaccaagctggaggtggcggtgctgcaggaaagtgtcgcaaag ttgggcatcgcatccagggctgagattgaggactggttcacggcagagaccctgggagtg tctggcaccatggacctgctggactggagcagcctcatcgacagcaggaccaagctgtcc aagcacttggtagtccccaacgcacagacaggacagctggagcccctgctgtcccggttc actgaggaggaggagctacagatgaccaggatgctacagcggatggatgtcctggccaag aaagccacagagatgggcgtgcggctgatggtggatgccgagcagacctacttccagccg gccatcagccgcctgacgctggagatgcagcggaagttcaatgtggagaagccgctcatc ttcaacacataccagtgctacctcaaggatgcctatgacaatgtgaccctggacgtggag ctggctcgccgtgagggctggtgttttggggccaagctggtgcggggcgcatacctggcc caggagcgagcccgtgcggcagagatcggctatgaggaccccatcaaccccacgtacgag gccaccaacgccatgtaccacaggtgcctggactacgtgttggaggagctgaagcacaac gccaaggccaaggtgatggtggcctcccacaatgaggacacagtgcgctttgcactgcgc aggatggaggagctgggcctgcatcctgctgaccaccaggtgtactttggacagctgcta ggcatgtgtgaccagatcagcttcccgctgggccaggccggctaccccgtgtacaagtac gtgccctatggccccgtgatggaggtgctgccctacttgtcccgccgtgccctggagaac agcagcctcatgaagggcacccatcgggagcggcagctgctgtggctggagctcttgagg cggctccgaactggcaacctcttccatcgccctgcctag |
Protein Sequence |
>5625 : length: 492 MKMTFYGHFVAGEDQESIQPLLRHYRAFGVSAILDYGVEEDLSPEEAEHKEMESCTSAAE RDGSGTNKRDKQYQAHRAFGDRRNGVISARTYFYANEAKCDSHMETFLRCIEASGRVSDD GFIAIKLTALGRPQFLLQFSEVLAKWRCFFHQMAVEQGQAGLAAMDTKLEVAVLQESVAK LGIASRAEIEDWFTAETLGVSGTMDLLDWSSLIDSRTKLSKHLVVPNAQTGQLEPLLSRF TEEEELQMTRMLQRMDVLAKKATEMGVRLMVDAEQTYFQPAISRLTLEMQRKFNVEKPLI FNTYQCYLKDAYDNVTLDVELARREGWCFGAKLVRGAYLAQERARAAEIGYEDPINPTYE ATNAMYHRCLDYVLEELKHNAKAKVMVASHNEDTVRFALRRMEELGLHPADHQVYFGQLL GMCDQISFPLGQAGYPVYKYVPYGPVMEVLPYLSRRALENSSLMKGTHRERQLLWLELLR RLRTGNLFHRPA |