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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 56999 |
Name | ADAMTS9 |
Synonym | -;ADAM metallopeptidase with thrombospondin type 1 motif, 9;ADAMTS9;ADAM metallopeptidase with thrombospondin type 1 motif, 9 |
Definition | A disintegrin and metalloproteinase with thrombospondin motifs 9|ADAM-TS 9|ADAM-TS9|ADAMTS-9|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 |
Position | 3p14.1 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | The metalloprotease ADAMTS9 participates in melanoblast development and is a tumor suppressor in esophageal and nasopharyngeal cancer. . |
reviewed | "The ADAMTS9 gene (ADAM metallopeptidase with thrombospondin type 1 motif, 9); has been characterized as a novel tumor suppressor gene in and epigenetically silenced in association with lymph node metastases in nasopharyngeal carcinoma." |
potential | These findings support ADAMTS9 as a putative tumor suppressor gene in vivo in NPC that is significantly associated with lymph node metastases. |
potential | "Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9." |
| More detail of all 4 literatures about ADAMTS9 | |
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External Links |
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Links to Entrez Gene | 56999 |
Links to all GeneRIF Items | 56999 |
Links to iHOP | 56999 |
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Sequence Information |
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Nucleotide Sequence |
>56999 : length: 5808 atgcagtttgtatcctgggccacactgctaacgctcctggtgcgggacctggccgagatg gggagcccagacgccgcggcggccgtgcgcaaggacaggctgcacccgaggcaagtgaaa ttattagagaccctgagcgaatacgaaatcgtgtctcccatccgagtgaacgctctcgga gaaccctttcccacgaacgtccacttcaaaagaacgcgacggagcattaactctgccact gacccctggcctgccttcgcctcctcctcttcctcctctacctcctcccaggcgcattac cgcctctctgccttcggccagcagtttctatttaatctcaccgccaatgccggatttatc gctccactgttcactgtcaccctcctcgggacgcccggggtgaatcagaccaagttttat tccgaagaggaagcggaactcaagcactgtttctacaaaggctatgtcaataccaactcc gagcacacggccgtcatcagcctctgctcaggaatgctgggcacattccggtctcatgat ggggattattttattgaaccactacagtctatggatgaacaagaagatgaagaggaacaa aacaaaccccacatcatttataggcgcagcgccccccagagagagccctcaacaggaagg catgcatgtgacacctcagaacacaaaaataggcacagtaaagacaagaagaaaaccaga gcaagaaaatggggagaaaggattaacctggctggtgacgtagcagcattaaacagcggc ttagcaacagaggcattttctgcttatggtaataagacggacaacacaagagaaaagagg acccacagaaggacaaaacgttttttatcctatccacggtttgtagaagtcttggtggtg gcagacaacagaatggtttcataccatggagaaaaccttcaacactatattttaacttta atgtcaattgtagcctctatctataaagacccaagtattggaaatttaattaatattgtt attgtgaacttaattgtgattcataatgaacaggatgggccttccatatcttttaatgct cagacaacattaaaaaacttttgccagtggcagcattcgaagaacagtccaggtggaatc catcatgatactgctgttctcttaacaagacaggatatctgcagagctcacgacaaatgt gataccttaggcctggctgaactgggaaccatttgtgatccctatagaagctgttctatt agtgaagatagtggattgagtacagcttttacgatcgcccatgagctgggccatgtgttt aacatgcctcatgatgacaacaacaaatgtaaagaagaaggagttaagagtccccagcat gtcatggctccaacactgaacttctacaccaacccctggatgtggtcaaagtgtagtcga aaatatatcactgagtttttagacactggttatggcgagtgtttgcttaacgaacctgaa tccagaccctaccctttgcctgtccaactgccaggcatcctttacaacgtgaataaacaa tgtgaattgatttttggaccaggttctcaggtgtgcccatatatgatgcagtgcagacgg ctctggtgcaataacgtcaatggagtacacaaaggctgccggactcagcacacaccctgg gccgatgggacggagtgcgagcctggaaagcactgcaagtatggattttgtgttcccaaa gaaatggatgtccccgtgacagatggatcctggggaagttggagtccctttggaacctgc tccagaacatgtggagggggcatcaaaacagccattcgagagtgcaacagaccagaacca aaaaatggtggaaaatactgtgtaggacgtagaatgaaatttaagtcctgcaacacggag ccatgtctcaagcagaagcgagacttccgagatgaacagtgtgctcactttgacgggaag cattttaacatcaacggtctgcttcccaatgtgcgctgggtccctaaatacagtggaatt ctgatgaaggaccggtgcaagttgttctgcagagtggcagggaacacagcctactatcag cttcgagacagagtgatagatggaactccttgtggccaggacacaaatgatatctgtgtc cagggcctttgccggcaagctggatgcgatcatgttttaaactcaaaagcccggagagat aaatgtggggtttgtggtggcgataattcttcatgcaaaacagtggcaggaacatttaat acagtacattatggttacaatactgtggtccgaattccagctggtgctaccaatattgat gtgcggcagcacagtttctcaggggaaacagacgatgacaactacttagctttatcaagc agtaaaggtgaattcttgctaaatggaaactttgttgtcacaatggccaaaagggaaatt cgcattgggaatgctgtggtagagtacagtgggtccgagactgccgtagaaagaattaac tcaacagatcgcattgagcaagaacttttgcttcaggttttgtcggtgggaaagttgtac aaccccgatgtacgctattctttcaatattccaattgaagataaacctcagcagttttac tggaacagtcatgggccatggcaagcatgcagtaaaccctgccaaggggaacggaaacga aaacttgtttgcaccagggaatctgatcagcttactgtttctgatcaaagatgcgatcgg ctgccccagcctggacacattactgaaccctgtggtacagactgtgacctgaggtggcat gttgccagcaggagtgaatgtagtgcccagtgtggcttgggttaccgcacattggacatc tactgtgccaaatatagcaggctggatgggaagactgagaaggttgatgatggtttttgc agcagccatcccaaaccaagcaaccgtgaaaaatgctcaggggaatgtaacacgggtggc tggcgctattctgcctggactgaatgttcaaaaagctgtgacggtgggacccagaggaga agggctatttgtgtcaatacccgaaatgatgtactggatgacagcaaatgcacacatcaa gagaaagttaccattcagaggtgcagtgagttcccttgtccacagtggaaatctggagac tggtcagagtgcttggtcacctgtggaaaagggcataagcaccgccaggtctggtgtcag tttggtgaagatcgattaaatgatagaatgtgtgaccctgagaccaagccaacatctatg cagacttgtcagcagccggaatgtgcatcctggcaggcgggtccctggggacagtgcagt gtcacttgtggacagggataccagctaagagcagtgaaatgcatcattgggacttatatg tcagtggtagatgacaatgactgtaatgcagcaactagaccaactgatacccaggactgt gaattaccatcatgtcatcctcccccagctgccccggaaacgaggagaagcacatacagt gcaccaagaacccagtggcgatttgggtcttggaccccatgctcagccacttgtgggaaa ggtacccggatgagatacgtcagctgccgagatgagaatggctctgtggctgacgagagt gcctgtgctaccctgcctagaccagtggcaaaggaagaatgttctgtgacaccctgtggg caatggaaggccttggactggagctcttgctctgtgacctgtgggcaaggtagggcaacc cggcaagtgatgtgtgtcaactacagtgaccacgtgatcgatcggagtgagtgtgaccag gattatatcccagaaactgaccaggactgttccatgtcaccatgccctcaaaggacccca gacagtggcttagctcagcaccccttccaaaatgaggactatcgtccccggagcgccagc cccagccgcacccatgtgctcggtggaaaccagtggagaactggcccctggggagcatgt tccagtacctgtgctggcggatcccagcggcgtgttgttgtatgtcaggatgaaaatgga tacaccgcaaacgactgtgtggagagaataaaacctgatgagcaaagagcctgtgaatcc ggcccttgtcctcagtgggcttatggcaactggggagagtgcactaagctgtgtggtgga ggcataagaacaagactggtggtctgtcagcggtccaacggtgaacggtttccagatttg agctgtgaaattcttgataaacctcccgatcgtgagcagtgtaacacacatgcttgtcca cacgacgctgcatggagtactggcccttggagctcgtgttctgtctcttgtggtcgaggg cataaacaacgaaatgtttactgcatggcaaaagatggaagccatttagaaagtgattac tgtaagcacctggctaagccacatgggcacagaaagtgccgaggaggaagatgccccaaa tggaaagctggcgcttggagtcagtgctctgtgtcctgtggccgaggcgtacagcagagg catgtgggctgtcagatcggaacacacaaaatagccagagagaccgagtgcaacccatac accagaccggagtcggaacgcgactgccaaggcccacggtgtcccctctacacttggagg gcagaggaatggcaagaatgcaccaagacctgcggcgaaggctccaggtaccgcaaggtg gtgtgtgtggatgacaacaaaaacgaggtgcatggggcacgctgtgacgtgagcaagcgg ccggtggaccgtgaaagctgtagtttgcaaccctgcgagtatgtctggatcacaggagaa tggtcagagtgctcagtgacctgtggaaaaggctacaaacaaaggcttgtctcgtgcagc gagatttacaccgggaaggagaattatgaatacagctaccaaaccaccatcaactgccca ggcacgcagccccccagtgttcacccctgttacctgagggactgccctgtctcggccacc tggagagttggcaactgggggagctgctcagtgtcttgtggtgttggagtgatgcagaga tctgtgcaatgtttaaccaatgaggaccaacccagccacttatgccacactgatctgaag ccagaagaacgaaaaacctgccgtaatgtctataactgtgagttaccccagaattgcaag gaggtaaaaagacttaaaggtgccagtgaagatggtgaatatttcctgatgattagagga aagcttctgaagatattctgtgcggggatgcactctgaccaccccaaagagtacgtgaca ctggtgcatggagactctgagaatttctccgaggtttatgggcacaggttacacaaccca acagaatgtccctataacgggagccggcgcgatgactgccaatgtcggaaggattacacg gccgctgggttttccagttttcagaaaatcagaatagacctgaccagcatgcagataatc accactgacttacagtttgcaaggacaagcgaaggacatcccgtcccttttgccacagcc ggggattgctacagcgctgccaagtgcccacagggtcgttttagcatcaacctttatgga accggcttgtctttaactgaatctgccagatggatatcacaagggaattatgctgtctct gacatcaagaagtcgccggatggtacccgagtcgtagggaaatgcggtggttactgtgga aaatgcactccatcctctggtactggcctggaggtgcgagttttatag |
Protein Sequence |
>56999 : length: 1935 MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALG EPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFI APLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHD GDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTR ARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVV ADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNA QTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSI SEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSR KYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRR LWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTC SRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGK HFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICV QGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNID VRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERIN STDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKR KLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDI YCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRR RAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQ FGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYM SVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK GTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRAT RQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSAS PSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACES GPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWR AEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGE WSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSAT WRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCK EVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNP TECPYNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATA GDCYSAAKCPQGRFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCG KCTPSSGTGLEVRVL |