Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5795

Name

PTPRJ

Synonym

CD148|DEP1|HPTPeta|R-PTP-ETA|SCC1;protein tyrosine phosphatase, receptor type, J;PTPRJ;protein tyrosine phosphatase, receptor type, J

Definition

CD148 antigen|DEP-1|HPTP eta|R-PTP-J|density-enhanced phosphatase 1|human density enhanced phosphatase-1|protein tyrosine phosphatase, receptor type, J polypeptide|protein-tyrosine phosphatase eta|protein-tyrosine phosphatase receptor type J|receptor-type

Position

11p11.2

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 5 PubMed records as below.

Evidence Status

Description

reviewed

Germline epigenetic silencing of the tumor suppressor gene PTPRJ in early-onset familial colorectal cancer.

reviewed

DEP-1 is a tumor suppressor that dephosphorylates and thereby stabilizes EGFR by hampering its ability to associate with the CBL-GRB2 ubiquitin ligase complex.

reviewed

tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.

potential

"A candidate tumor suppressor gene because its expression was blocked in rat and human thyroid transformed cells, and its restoration reverted their neoplastic phenotype."

potential

negative regulation of growth-factor stimulated cell migration and promotion of cell-matrix adhesion may be related to the function of DEP-1 as tumor suppressor.
More detail of all 5 literatures about PTPRJ

Pathways and Diseases

Pathway

Adherens junction;KEGG PATHWAY;hsa04520

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032

Pathway

PDGFR-beta signaling pathway;PID Curated;200127

Disease

Hypothyroidism;FunDO

Disease

Thyroid cancer;FunDO

Disease

Colon cancer, somatic;OMIM

Disease

thyroid cancer;GAD

Disease

CANCER;GAD

Disease

Deafness;FunDO

Disease

Brain tumor;FunDO

Disease

Breast cancer;FunDO

External Links

Links to Entrez Gene

5795

Links to all GeneRIF Items

5795

Links to iHOP

5795

Sequence Information

Nucleotide Sequence

>5795 : length: 1620
atgaagccggcggcgcgggaggcgcggctgcctccgcgctcgcccgggctgcgctgggcg
ctgccgctgctgctgctgctgctgcgcctgggccagatcctgtgcgcaggtggcacccct
agtccaattcctgacccttcagtagcaactgttgccacaggggaaaatggcataacgcag
atcagcagtacagcagaatcctttcataaacagaatggaactggaacacctcaggtggaa
acaaacaccagtgaggatggtgaaagctctggagccaacgatagtttaagaacacctgaa
caaggatctaatgggactgatggggcatctcaaaaaactcccagtagcactgggcccagt
cctgtgtttgacattaaagctgtttccatcagtccaaccaatgtgatcttaacttggaaa
agtaatgacacagctgcttctgagtacaagtatgtagtaaagcataagatggaaaatgag
aagacaattactgttgtgcatcaaccatggtgtaacatcacaggcttacgtccagcgact
tcatatgtattctccatcactccaggaataggcaatgagacttggggagatcccagagtc
ataaaagtcatcacagagccgatcccagtttctgatctccgtgttgccctcacgggtgtg
aggaaggctgctctctcctggagcaatggcaatggcactgcctcctgccgggttcttctt
gaaagcattggaagccatgaggagttgactcaagactcaagacttcaggtcaatatctcg
ggcctgaagccaggggttcaatacaacatcaacccgtatcttctacaatcaaataagaca
aagggagaccccttgggcacagaaggtggcttggatgccagcaatacagagagaagccgg
gcagggagccccaccgcccctgtgcatgatgagtccctcgtgggacctgtggacccatcc
tccggccagcagtcccgagacacggaagtcctgcttgtcgggttagagcctggcacccga
tacaatgccaccgtttattcccaagcagcgaatggcacagaaggacagccccaggccata
gagttcaggacaaatgctattcaggtttttgacgtcaccgctgtgaacatcagtgccaca
agcctgaccctgatctggaaagtcagcgataacgagtcgtcatctaactatacctacaag
atacatgtggcgggggagacagattcttccaatctcaacgtcagtgagcctcgcgctgtc
atccccggactccgctccagcaccttctacaacatcacagtgtgtcctgtcctaggtgac
atcgagggcacgccgggcttcctccaagtgcacaccccccctgttccagtttctgacttc
cgagtgacagtggtcagcacgacggagatcggcttagcatggagcagccatgatgcagaa
tcatttcagatgcatatcacacaggagggagctggcaattctcgggtagaaataaccacc
aaccaaagtattatcattggtggcttgttccctggaaccaagtattgctttgaaatagtt
ccaaaaggaccaaatgggactgaaggggcatctcggacagtttgcaatagaactggatga

Protein Sequence

>5795 : length: 539
MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ
ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS
PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT
SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR
AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI
EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV
IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTG



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