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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5796 |
Name | PTPRK |
Synonym | R-PTP-kappa;protein tyrosine phosphatase, receptor type, K;PTPRK;protein tyrosine phosphatase, receptor type, K |
Definition | dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa|protein-tyrosine phosphatase kappa|protein-tyrosine phosphatase, receptor type, kappa|receptor-type tyrosine |
Position | 6q22.2-q22.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
potential | Cytogenetical assignment and physical mapping of the human R-PTP-kappa gene (PTPRK) to the putative tumor suppressor gene region 6q22.2-q22.3. |
potential | "PTPRK influences transactivating activity of beta-catenin in non-tumoral and neoplastic cells by regulating the balance between signaling and adhesive beta-catenin, thus providing biochemical basis for the hypothesis of PTPRK as a tumor suppressor gene." |
reviewed | "EBNA1 apparently disables TGF-beta signaling, which subsequently decreases transcription of the PTPRK tumor suppressor". |
| More detail of all 3 literatures about PTPRK | |
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Pathways and Diseases |
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Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Disease | IMMUNE;GAD |
Disease | Celiac Disease;GAD |
Disease | Cancer;FunDO |
Disease | Celiac disease;NHGRI |
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External Links |
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Links to Entrez Gene | 5796 |
Links to all GeneRIF Items | 5796 |
Links to iHOP | 5796 |
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Sequence Information |
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Nucleotide Sequence |
>5796 : length: 4341 atggatacgactgcggcggcggcgctgcctgcttttgtggcgctcttgctcctctctcct tggcctctcctgggatcggcccaaggccagttctccgcaggtggctgtacttttgatgat ggtccaggggcctgtgattaccaccaggatctgtatgatgactttgaatgggtgcatgtt agtgctcaagagcctcattatctaccacccgagatgccccaaggttcctatatgatagtg gactcttcagatcacgaccctggagaaaaagccagacttcagctgcctacaatgaaggag aacgacactcactgcattgatttcagttacctattatatagccagaaaggactgaatcct ggcactttgaacatattagttagggtgaataaaggacctcttgccaatccaatttggaat gtgactggattcacgggtagagattggcttcgggctgagctagcagtgagcaccttttgg cccaatgaatatcaggtaatatttgaagctgaagtctcaggagggagaagtggttatatt gccattgatgacatccaagtactgagttatccttgtgataaatctcctcatttcctccgt ctaggggatgtagaggtgaatgcagggcaaaacgctacatttcagtgcattgccacaggg agagatgctgtgcataacaagttatggctccagagacgaaatggagaagatataccagta gcccagactaagaacatcaatcatagaaggtttgccgcttccttcagattgcaagaagtg acaaaaactgaccaggatttgtatcgctgtgtaactcagtcagaacgaggttccggtgtg tccaattttgctcaacttattgtgagagaaccgccaagacccattgctcctcctcagctt cttggtgttgggcctacatatttgctgatccaactaaatgccaactcgatcattggcgat ggtcctatcatcctgaaagaagtagagtaccgaatgacatcaggatcctggacagaaacc catgcagtcaatgctccaacttacaaattatggcatttagatccagataccgaatatgag atccgagttctacttacaagacctggtgaaggtggaacggggctcccaggacctccacta atcaccagaacaaaatgtgcagaacctatgagaaccccaaagacattaaagattgctgaa atacaggcaagacggattgctgtggactgggaatccttgggttacaacattacgcgttgc cacacttttaatgtcactatctgctaccattacttccgtggtcacaacgagagcaaggca gactgtttggacatggaccccaaagcccctcagcatgttgtgaaccatctgccaccttat acaaatgtcagcctcaagatgatcctaaccaatccagagggaaggaaggagagtgaagag acaattattcaaactgatgaagatgtgcctggtcccgtaccagtaaaatctcttcaagga acatcctttgaaaataagatcttcttgaactggaaagaacctttggatccaaatggaatc atcactcaatatgagatcagctatagcagtataagatcatttgatcctgcagttccagtg gctggacctccccagactgtatcaaatttatggaacagtacacaccatgtctttatgcat ctccaccctggaaccacgtaccagtttttcataagagccagcacggtcaaaggctttggt ccagccacagccatcaatgtcaccaccaatatctcagctccaactttacctgactatgaa ggagttgatgcctctctcaatgaaactgccaccacaataactgtattgttgagaccagca caagccaaaggtgctcctatcagtgcttatcagattgttgtggaagaactgcacccacac cgaaccaagagagaagccggagccatggaatgctaccaggttcctgtcacataccaaaat gccatgagtgggggtgcaccgtattactttgctgcagaactccccccgggaaacctacct gagcctgccccgttcactgtgggtgacaatcggacctaccaaggcttttggaaccctcct ttggctccgcgcaaaggatacaacatctatttccaggcgatgagcagtgtggagaaggaa actaaaacccagtgcgtacgcattgctacaaaagcagcagcaacagaagaaccagaagtg atcccagatcccgccaagcagacagacagagtggtgaaaatagcaggaattagtgctgga attttggtgttcatcctccttctcctagttgtcatattaattgtaaaaaagagcaaactt gctaaaaaacgcaaagatgccatggggaatacccggcaggagatgactcacatggtgaat gcaatggatcgaagttatgctgatcagagcactctgcatgcagaagatcctctttccatc accttcatggaccaacataactttagtccaagatatgagaaccacagtgctacagcagag tccagtcgccttctagacgtacctcgctacctctgtgaggggacggaatccccttaccag acaggacagctgcatccagccatcagggtagctgatttactgcagcacattaatctcatg aagacatcagacagctatgggttcaaagaggaatatgagagcttttttgaaggacagtca gcatcttgggatgtagctaaaaaagatcaaaatagagcaaaaaaccgatatggaaacatt atagcatatgatcactccagagtgattttgcaacccgtagaggatgatccttcctcagat tatattaatgccaactatattgatatttggctgtacagggatggctaccagagaccaagt cattacattgcaacccaaggtcccgttcatgaaacagtgtatgatttctggaggatgatt tggcaagaacaatctgcttgcattgtgatggttacaaatttagttgaggttggccgggtt aaatgctataaatattggcctgatgatactgaagtttatggtgacttcaaagtaacgtgt gtagaaatggaaccacttgctgaatatgtagttaggacattcaccctggaaaggaggggg tacaatgaaatccgtgaagttaaacagttccatttcacgggctggcctgaccatggagtg ccctaccatgctacagggctgctttcctttatccggcgagtcaagttatcaaaccctccc agtgctggccccatcgttgtacattgcagtgctggtgctggacgaactggctgctacatt gtgattgacatcatgctagacatggctgaaagagagggtgttgttgatatttacaattgt gtcaaagccttaagatctcggcgtattaatatggtccagacagaggaacagtacattttt attcatgatgccattttagaagcctgcttatgtggagaaactgccatacctgtctgtgaa tttaaagctgcatattttgatatgattagaatagactcccagactaactcttcacatctc aaggatgaatttcagactctgaattcagtcacccctcgactacaagctgaagactgcagt atagcgtgcctgccaaggaaccatgacaagaaccgtttcatggacatgctgccacctgac agatgtctgccttttttaattacaattgatggggagagcagtaactacatcaatgctgct cttatggacagctacaggcaaccagctgctttcatcgtcacacaataccctctgccaaac actgtaaaagacttctggagattagtgtatgattatggctgtacctccattgtgatgtta aacgaagtcgacttgtcccagggctgccctcagtactggccagaggaagggatgctacga tatggccccatccaagtggaatgtatgtcttgttcaatggactgtgatgtgatcaaccgg atttttaggatatgcaatctaacaagaccacaggaaggttatctgatggtgcaacagttt cagtacctaggatgggcttctcatcgagaagtgcctggatccaaaaggtcattcttgaaa ctgatacttcaggtggaaaagtggcaggaggaatgcgaggaaggggaaggccggacgatt atccactgcctaaatggtggcgggcgaagtggcatgttctgtgctataggcatcgttgtt gaaatggtgaaacggcaaaatgttgtcgatgttttccatgcagtaaagacactgaggaac agcaagccaaacatggtggaagccccggagcaataccgtttctgctatgatgtagctttg gagtacctggaatcatcttag |
Protein Sequence |
>5796 : length: 1446 MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPS HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL EYLESS |