Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5796

Name

PTPRK

Synonym

R-PTP-kappa;protein tyrosine phosphatase, receptor type, K;PTPRK;protein tyrosine phosphatase, receptor type, K

Definition

dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa|protein-tyrosine phosphatase kappa|protein-tyrosine phosphatase, receptor type, kappa|receptor-type tyrosine

Position

6q22.2-q22.3

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 3 PubMed records as below.

Evidence Status

Description

potential

Cytogenetical assignment and physical mapping of the human R-PTP-kappa gene (PTPRK) to the putative tumor suppressor gene region 6q22.2-q22.3.

potential

"PTPRK influences transactivating activity of beta-catenin in non-tumoral and neoplastic cells by regulating the balance between signaling and adhesive beta-catenin, thus providing biochemical basis for the hypothesis of PTPRK as a tumor suppressor gene."

reviewed

"EBNA1 apparently disables TGF-beta signaling, which subsequently decreases transcription of the PTPRK tumor suppressor".
More detail of all 3 literatures about PTPRK

Pathways and Diseases

Pathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039

Disease

IMMUNE;GAD

Disease

Celiac Disease;GAD

Disease

Cancer;FunDO

Disease

Celiac disease;NHGRI

External Links

Links to Entrez Gene

5796

Links to all GeneRIF Items

5796

Links to iHOP

5796

Sequence Information

Nucleotide Sequence

>5796 : length: 4341
atggatacgactgcggcggcggcgctgcctgcttttgtggcgctcttgctcctctctcct
tggcctctcctgggatcggcccaaggccagttctccgcaggtggctgtacttttgatgat
ggtccaggggcctgtgattaccaccaggatctgtatgatgactttgaatgggtgcatgtt
agtgctcaagagcctcattatctaccacccgagatgccccaaggttcctatatgatagtg
gactcttcagatcacgaccctggagaaaaagccagacttcagctgcctacaatgaaggag
aacgacactcactgcattgatttcagttacctattatatagccagaaaggactgaatcct
ggcactttgaacatattagttagggtgaataaaggacctcttgccaatccaatttggaat
gtgactggattcacgggtagagattggcttcgggctgagctagcagtgagcaccttttgg
cccaatgaatatcaggtaatatttgaagctgaagtctcaggagggagaagtggttatatt
gccattgatgacatccaagtactgagttatccttgtgataaatctcctcatttcctccgt
ctaggggatgtagaggtgaatgcagggcaaaacgctacatttcagtgcattgccacaggg
agagatgctgtgcataacaagttatggctccagagacgaaatggagaagatataccagta
gcccagactaagaacatcaatcatagaaggtttgccgcttccttcagattgcaagaagtg
acaaaaactgaccaggatttgtatcgctgtgtaactcagtcagaacgaggttccggtgtg
tccaattttgctcaacttattgtgagagaaccgccaagacccattgctcctcctcagctt
cttggtgttgggcctacatatttgctgatccaactaaatgccaactcgatcattggcgat
ggtcctatcatcctgaaagaagtagagtaccgaatgacatcaggatcctggacagaaacc
catgcagtcaatgctccaacttacaaattatggcatttagatccagataccgaatatgag
atccgagttctacttacaagacctggtgaaggtggaacggggctcccaggacctccacta
atcaccagaacaaaatgtgcagaacctatgagaaccccaaagacattaaagattgctgaa
atacaggcaagacggattgctgtggactgggaatccttgggttacaacattacgcgttgc
cacacttttaatgtcactatctgctaccattacttccgtggtcacaacgagagcaaggca
gactgtttggacatggaccccaaagcccctcagcatgttgtgaaccatctgccaccttat
acaaatgtcagcctcaagatgatcctaaccaatccagagggaaggaaggagagtgaagag
acaattattcaaactgatgaagatgtgcctggtcccgtaccagtaaaatctcttcaagga
acatcctttgaaaataagatcttcttgaactggaaagaacctttggatccaaatggaatc
atcactcaatatgagatcagctatagcagtataagatcatttgatcctgcagttccagtg
gctggacctccccagactgtatcaaatttatggaacagtacacaccatgtctttatgcat
ctccaccctggaaccacgtaccagtttttcataagagccagcacggtcaaaggctttggt
ccagccacagccatcaatgtcaccaccaatatctcagctccaactttacctgactatgaa
ggagttgatgcctctctcaatgaaactgccaccacaataactgtattgttgagaccagca
caagccaaaggtgctcctatcagtgcttatcagattgttgtggaagaactgcacccacac
cgaaccaagagagaagccggagccatggaatgctaccaggttcctgtcacataccaaaat
gccatgagtgggggtgcaccgtattactttgctgcagaactccccccgggaaacctacct
gagcctgccccgttcactgtgggtgacaatcggacctaccaaggcttttggaaccctcct
ttggctccgcgcaaaggatacaacatctatttccaggcgatgagcagtgtggagaaggaa
actaaaacccagtgcgtacgcattgctacaaaagcagcagcaacagaagaaccagaagtg
atcccagatcccgccaagcagacagacagagtggtgaaaatagcaggaattagtgctgga
attttggtgttcatcctccttctcctagttgtcatattaattgtaaaaaagagcaaactt
gctaaaaaacgcaaagatgccatggggaatacccggcaggagatgactcacatggtgaat
gcaatggatcgaagttatgctgatcagagcactctgcatgcagaagatcctctttccatc
accttcatggaccaacataactttagtccaagatatgagaaccacagtgctacagcagag
tccagtcgccttctagacgtacctcgctacctctgtgaggggacggaatccccttaccag
acaggacagctgcatccagccatcagggtagctgatttactgcagcacattaatctcatg
aagacatcagacagctatgggttcaaagaggaatatgagagcttttttgaaggacagtca
gcatcttgggatgtagctaaaaaagatcaaaatagagcaaaaaaccgatatggaaacatt
atagcatatgatcactccagagtgattttgcaacccgtagaggatgatccttcctcagat
tatattaatgccaactatattgatatttggctgtacagggatggctaccagagaccaagt
cattacattgcaacccaaggtcccgttcatgaaacagtgtatgatttctggaggatgatt
tggcaagaacaatctgcttgcattgtgatggttacaaatttagttgaggttggccgggtt
aaatgctataaatattggcctgatgatactgaagtttatggtgacttcaaagtaacgtgt
gtagaaatggaaccacttgctgaatatgtagttaggacattcaccctggaaaggaggggg
tacaatgaaatccgtgaagttaaacagttccatttcacgggctggcctgaccatggagtg
ccctaccatgctacagggctgctttcctttatccggcgagtcaagttatcaaaccctccc
agtgctggccccatcgttgtacattgcagtgctggtgctggacgaactggctgctacatt
gtgattgacatcatgctagacatggctgaaagagagggtgttgttgatatttacaattgt
gtcaaagccttaagatctcggcgtattaatatggtccagacagaggaacagtacattttt
attcatgatgccattttagaagcctgcttatgtggagaaactgccatacctgtctgtgaa
tttaaagctgcatattttgatatgattagaatagactcccagactaactcttcacatctc
aaggatgaatttcagactctgaattcagtcacccctcgactacaagctgaagactgcagt
atagcgtgcctgccaaggaaccatgacaagaaccgtttcatggacatgctgccacctgac
agatgtctgccttttttaattacaattgatggggagagcagtaactacatcaatgctgct
cttatggacagctacaggcaaccagctgctttcatcgtcacacaataccctctgccaaac
actgtaaaagacttctggagattagtgtatgattatggctgtacctccattgtgatgtta
aacgaagtcgacttgtcccagggctgccctcagtactggccagaggaagggatgctacga
tatggccccatccaagtggaatgtatgtcttgttcaatggactgtgatgtgatcaaccgg
atttttaggatatgcaatctaacaagaccacaggaaggttatctgatggtgcaacagttt
cagtacctaggatgggcttctcatcgagaagtgcctggatccaaaaggtcattcttgaaa
ctgatacttcaggtggaaaagtggcaggaggaatgcgaggaaggggaaggccggacgatt
atccactgcctaaatggtggcgggcgaagtggcatgttctgtgctataggcatcgttgtt
gaaatggtgaaacggcaaaatgttgtcgatgttttccatgcagtaaagacactgaggaac
agcaagccaaacatggtggaagccccggagcaataccgtttctgctatgatgtagctttg
gagtacctggaatcatcttag

Protein Sequence

>5796 : length: 1446
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHV
SAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNP
GTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPV
AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQL
LGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRC
HTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEE
TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV
AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYE
GVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQN
AMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE
TKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKL
AKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAE
SSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS
ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPS
HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC
VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP
SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF
IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS
IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN
TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR
IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI
IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL
EYLESS



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