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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5906 |
Name | RAP1A |
Synonym | KREV-1|KREV1|RAP1|SMGP21;RAP1A, member of RAS oncogene family;RAP1A;RAP1A, member of RAS oncogene family |
Definition | C21KG|G-22K|GTP-binding protein smg p21A|RAS-related protein RAP1A|Ras-related protein Krev-1|ras-related protein Rap-1A |
Position | 1p13.3 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,Generif,UniProt |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Rap1A binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. |
reviewed | The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells. |
| More detail of all 2 literatures about RAP1A | |
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Pathways and Diseases |
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Pathway | ARMS-mediated activation;PID Reactome;500631 |
Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | Frs2-mediated activation;PID Reactome;500630 |
Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway;PANTHER;P00026 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | Pancreatic secretion;KEGG PATHWAY;hsa04972 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Disease | Herpes;FunDO |
Disease | Squamous cell cancer;FunDO |
Disease | Emphysema;FunDO |
Disease | Azoospermia;FunDO |
Disease | Osteoporosis;NHGRI |
Disease | Eating disorder;FunDO |
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External Links |
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Links to Entrez Gene | 5906 |
Links to all GeneRIF Items | 5906 |
Links to iHOP | 5906 |
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Sequence Information |
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Nucleotide Sequence |
>5906 : length: 555 atgcgtgagtacaagctagtggtccttggttcaggaggcgttgggaagtctgctctgaca gttcagtttgttcagggaatttttgttgaaaaatatgacccaacgatagaagattcctac agaaagcaagttgaagtcgattgccaacagtgtatgctcgaaatcctggatactgcaggg acagagcaatttacagcaatgagggatttgtatatgaagaacggccaaggttttgcacta gtatattctattacagctcagtccacgtttaacgacttacaggacctgagggaacagatt ttacgggttaaggacacggaagatgttccaatgattttggttggcaataaatgtgacctg gaagatgagcgagtagttggcaaagagcagggccagaatttagcaagacagtggtgtaac tgtgcctttttagaatcttctgcaaagtcaaagatcaatgttaatgagatattttatgac ctggtcagacagataaataggaaaacaccagtggaaaagaagaagcctaaaaagaaatca tgtctgctgctctag |
Protein Sequence |
>5906 : length: 184 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS CLLL |