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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5934 |
Name | RBL2 |
Synonym | P130|Rb2;retinoblastoma-like 2 (p130);RBL2;retinoblastoma-like 2 (p130) |
Definition | 130 kDa retinoblastoma-associated protein|PRB2|RBR-2|retinoblastoma-like protein 2|retinoblastoma-related protein 2 |
Position | 16q12.2 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 9 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Characterization of alterations of Rb2/p130 tumor suppressor in all-trans-retinoic acid resistant SK-OV3 ovarian carcinoma cells. |
reviewed | "There was a strong correlation between the expression of p130 in Stage 1 & 3, but not Stage 2, tumors. High levels of p130 were detected in the cytoplasm rather than the nucleus, suggesting an aberrant subcellular localization of this tumor suppressor." |
potential | "pRb2/p130 overexpression is able to arrest cell growth in ovarian carcinoma cells, suggesting the putative role of pRb2/p130 as a tumor suppressor in this malignancy." |
reviewed | Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity. |
reviewed | Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesis. |
reviewed | The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase. |
reviewed | miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. |
reviewed | Compensation by tumor suppressor genes during retinal development in mice and humans. |
reviewed | Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. |
| More detail of all 9 literatures about RBL2 | |
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Pathways and Diseases |
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Pathway | mets affect on macrophage differentiation;PID BioCarta;100169 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Disease | Cancer;FunDO |
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External Links |
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Links to Entrez Gene | 5934 |
Links to all GeneRIF Items | 5934 |
Links to iHOP | 5934 |
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Sequence Information |
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Nucleotide Sequence |
>5934 : length: 3420 atgccgtcgggaggtgaccagtcgccaccgcccccgcctccccctccggcggcggcagcc tcggatgaggaggaggaggacgacggcgaggcggaagacgccgcgccgcctgccgagtcg cccacccctcagatccagcagcggttcgacgagctgtgcagccgcctcaacatggacgag gcggcgcgggccgaggcctgggacagctaccgcagcatgagcgaaagctacacgctggag ggaaatgatcttcattggttagcatgtgccttatatgtggcttgcagaaaatctgttcca actgtaagcaaagggacagtggaaggaaactatgtatctttaactagaatcctgaaatgt tcagagcagagcttaatcgaattttttaataagatgaagaagtgggaagacatggcaaat ctacccccacatttcagagaacgtactgagagattagaaagaaacttcactgtttctgct gtaatttttaagaaatatgaacccatttttcaggacatctttaaataccctcaagaggag caacctcgtcagcagcgaggaaggaaacagcggcgacagccctgtactgtgtctgaaatt ttccatttttgttgggtgctttttatatatgcaaaaggtaatttccccatgattagtgat gatttggtcaattcttatcacctgctgctgtgtgctttggacttagtttatggaaatgca cttcagtgttctaatcgtaaagaacttgtgaaccctaattttaaaggcttatctgaagat tttcatgctaaagattctaaaccttcctctgaccccccttgtatcattgagaaactgtgt tccttacatgatggcctagttttggaagcaaaggggataaaggaacatttctggaaaccc tatattaggaaactttatgaaaaaaagctccttaagggaaaagaagaaaatctcactggg tttctagaacctgggaactttggagagagttttaaagccatcaataaggcctatgaggag tatgttttatctgttgggaatttagatgagcggatatttcttggagaggatgctgaggag gaaattgggactctctcaaggtgtctgaacgctggttcaggaacagagactgctgaaagg gtgcagatgaaaaacatcttacagcagcattttgacaagtccaaagcacttagaatctcc acaccactaactggtgttaggtacattaaggagaatagcccttgtgtgactccagtttct acagctacgcatagcttgagtcgtcttcacaccatgctgacaggcctcaggaatgcacca agtgagaaactggaacagattctcaggacatgttccagagatccaacccaggctattgct aacagactgaaagaaatgtttgaaatatattctcagcatttccagccagacgaggatttc agtaattgtgctaaagaaattgccagcaaacattttcgttttgcggagatgctttactat aaagtattagaatctgttattgagcaggaacaaaaaagactaggagacatggatttatct ggtattctggaacaagatgcgttccacagatctctcttggcctgctgccttgaggtcgtc actttttcttataagcctcctgggaattttccatttattactgaaatatttgatgtgcct ctttatcatttttataaggtgatagaagtattcattagagcagaagatggcctttgtaga gaggtggtaaaacaccttaatcagattgaagaacagatcttagatcatttggcatggaaa ccagagtctccactctgggaaaaaattagagacaatgaaaacagagttcctacatgtgaa gaggtcatgccacctcagaacctggaaagggcagatgaaatttgcattgctggctcccct ttgactcccagaagggtgactgaagttcgtgctgatactggaggacttggaaggagcata acatctccaaccacattatacgataggtacagctccccaccagccagcactaccagaagg cggctatttgttgagaatgatagcccctctgatggagggacgcctgggcgcatgccccca cagcccctagtcaatgctgtccctgtgcagaatgtatctggggagactgtttctgtcaca ccagttcctggacagactttggtcaccatggcaaccgccactgtcacagccaacaatggg caaacggtaaccattcctgtgcaaggtattgccaatgaaaatggagggataacattcttc cctgtccaagtcaatgttggggggcaggcacaagctgtgacaggctccatccagcccctc agtgctcaggccctggctggaagtctgagctctcaacaggtgacaggaacaactttgcaa gtccctggtcaagtggccattcaacagatttccccaggtggccaacagcagaagcaaggc cagtctgtaaccagcagtagtaatagacccaggaagaccagctctttatcgcttttcttt agaaaggtataccatttagcagctgtccgccttcgggatctctgtgccaaactagatatt tcagatgaattgaggaaaaaaatctggacctgctttgaattctccataattcagtgtcct gaacttatgatggacagacatctggaccagttattaatgtgtgccatttatgtgatggca aaggtcacaaaagaagataagtccttccagaacattatgcgttgttataggactcagccg caggcccggagccaggtgtatagaagtgttttgataaaagggaaaagaaaaagaagaaat tctggcagcagtgatagcagaagccatcagaattctccaacagaactaaacaaagataga accagtagagactccagtccagttatgaggtcaagcagcaccttgccagttccacagccc agcagtgctcctcccacacctactcgcctcacaggtgccaacagtgacatggaagaagag gagaggggagacctcattcagttctacaacaacatctacatcaaacagattaagacattt gccatgaagtactcacaggcaaatatggatgctcctccactctctccctatccatttgta agaacaggctcccctcgccgaatacagttgtctcaaaatcatcctgtctacatttcccca cataaaaatgaaacaatgctttctcctcgagaaaagattttctattacttcagcaacagt ccttcaaagagactgagagaaattaatagtatgatacgcacaggagaaactcctactaaa aagagaggaattcttttggaagatggaagtgaatcacctgcaaaaagaatttgcccagaa aatcattctgccttattacgccgtctccaagatgtagctaatgaccgtggttcccactga |
Protein Sequence |
>5934 : length: 1139 MPSGGDQSPPPPPPPPAAAASDEEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDE AARAEAWDSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKC SEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEE QPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNA LQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKP YIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEE EIGTLSRCLNAGSGTETAERVQMKNILQQHFDKSKALRISTPLTGVRYIKENSPCVTPVS TATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDF SNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVV TFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWK PESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSI TSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVT PVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPL SAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFF RKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMA KVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDR TSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTF AMKYSQANMDAPPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNS PSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRICPENHSALLRRLQDVANDRGSH |