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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 6041 |
Name | RNASEL |
Synonym | PRCA1|RNS4;ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent);RNASEL;ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) |
Definition | 2',5'-oligoisoadenylate synthetase-dependent|2-5A-dependent RNase|2-5A-dependent ribonuclease|RNase L|interferon-induced 2-5A-dependent RNase|ribonuclease 4 |
Position | 1q25 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
potential | RNase L could have a role in cancer biology and evidence of a tumor suppressor function of RNase L has emerged from studies on the genetics of hereditary prostate cancer [review]. |
potential | RNASEL may function as a tumor suppressor in prostate cancer. |
reviewed | "Author reviews the tumor suppressor role of RNase L, proposing that it functions in counteracting prostate cancer by virtue of its ability to degrade RNA, thus initiating a cellular stress response that leads to apoptosis." |
potential | "support a model in which the RNase-L-mediated degradation of ribosomal protein mRNAs inhibits translation, and may contribute to its antiproliferative, senescence inducing and tumor suppressor activities." |
| More detail of all 4 literatures about RNASEL | |
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Pathways and Diseases |
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Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Disease | Virus disease;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Chronic fatigue syndrome;FunDO |
Disease | Infection;FunDO |
Disease | Embryoma;FunDO |
Disease | Ovarian cancer;FunDO |
Disease | Prostate cancer 1;OMIM |
Disease | prostate cancer;GAD |
Disease | CANCER;GAD |
Disease | pancreatic cancer;GAD |
Disease | Pancreas cancer;FunDO |
Disease | Breast cancer;FunDO |
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External Links |
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Links to Entrez Gene | 6041 |
Links to all GeneRIF Items | 6041 |
Links to iHOP | 6041 |
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Sequence Information |
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Nucleotide Sequence |
>6041 : length: 2226 atggagagcagggatcataacaacccccaggagggacccacgtcctccagcggtagaagg gctgcagtggaagacaatcacttgctgattaaagctgttcaaaacgaagatgttgacctg gtccagcaattgctggaaggtggagccaatgttaatttccaggaagaggaagggggctgg acacctctgcataacgcagtacaaatgagcagggaggacattgtggaacttctgcttcgt catggtgctgaccctgttctgaggaagaagaatggggccacgccttttatcctcgcagcg attgcggggagcgtgaagctgctgaaacttttcctttctaaaggagcagatgtcaatgag tgtgatttttatggcttcacagccttcatggaagccgctgtgtatggtaaggtcaaagcc ctaaaattcctttataagagaggagcaaatgtgaatttgaggcgaaagacaaaggaggat caagagcggctgaggaaaggaggggccacagctctcatggacgctgctgaaaaaggacac gtagaggtcttgaagattctccttgatgagatgggggcagatgtaaacgcctgtgacaat atgggcagaaatgccttgatccatgctctcctgagctctgacgatagtgatgtggaggct attacgcatctgctgctggaccatggggctgatgtcaatgtgaggggagaaagagggaag actcccctgatcctggcagtggagaagaagcacttgggtttggtgcagaggcttctggag caagagcacatagagattaatgacacagacagtgatggcaaaacagcactgctgcttgct gttgaactcaaactgaagaaaatcgccgagttgctgtgcaaacgtggagccagtacagat tgtggggatcttgttatgacagcgaggcggaattatgaccattcccttgtgaaggttctt ctctctcatggagccaaagaagattttcaccctcctgctgaagactggaagcctcagagc tcacactggggggcagccctgaaggatctccacagaatataccgccctatgattggcaaa ctcaagttctttattgatgaaaaatacaaaattgctgatacttcagaaggaggcatctac ctggggttctatgagaagcaagaagtagctgtgaagacgttctgtgagggcagcccacgt gcacagcgggaagtctcttgtctgcaaagcagccgagagaacagtcacttggtgacattc tatgggagtgagagccacaggggccacttgtttgtgtgtgtcaccctctgtgagcagact ctggaagcgtgtttggatgtgcacagaggggaagatgtggaaaatgaggaagatgaattt gcccgaaatgtcctgtcatctatatttaaggctgttcaagaactacacttgtcctgtgga tacacccaccaggatctgcaaccacaaaacatcttaatagattctaagaaagctgctcac ctggcagattttgataagagcatcaagtgggctggagatccacaggaagtcaagagagat ctagaggaccttggacggctggtcctctatgtggtaaagaagggaagcatctcatttgag gatctgaaagctcaaagtaatgaagaggtggttcaactttctccagatgaggaaactaag gacctcattcatcgtctcttccatcctggggaacatgtgagggactgtctgagtgacctg ctgggtcatcccttcttttggacttgggagagccgctataggacgcttcggaatgtggga aatgaatccgacatcaaaacacgaaaatctgaaagtgagatcctcagactactgcaacct gggccttctgaacattccaaaagttttgacaagtggacgactaagattaatgaatgtgtt atgaaaaaaatgaataagttttatgaaaaaagaggcaatttctaccagaacactgtgggt gatctgctaaagttcatccggaatttgggagaacacattgatgaagaaaagcataaaaag atgaaattaaaaattggagacccttccctgtattttcagaagacatttccagatctggtg atctatgtctacacaaaactacagaacacagaatatagaaagcatttcccccaaacccac agtccaaacaagcctcagtgtgatggagctggtggggccagtgggttggccagccctggg tgctga |
Protein Sequence |
>6041 : length: 741 MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD CGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGK LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG NESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVG DLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTH SPNKPQCDGAGGASGLASPGC |