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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 613 |
Name | BCR |
Synonym | ALL|BCR1|CML|D22S11|D22S662|PHL;breakpoint cluster region;BCR;breakpoint cluster region |
Definition | breakpoint cluster region protein|renal carcinoma antigen NY-REN-26 |
Position | 22q11|22q11.23 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
|
Evidence Status |
Description |
potential | BCR can be considered as a candidate tumor suppressor gene localized on chromosome 22q which may be involved in meningioma pathogenesis. |
| More detail of all 1 literatures about BCR | |
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Pathways and Diseases |
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Pathway | ctcf: first multivalent nuclear factor;PID BioCarta;100194 |
Pathway | Regulation of RhoA activity;PID Curated;200050 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | Signaling by Rho GTPases;Reactome;REACT:11044 |
Pathway | Regulation of RAC1 activity;PID Curated;200165 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Disease | DEVELOPMENTAL;GAD |
Disease | Cancers;KEGG DISEASE |
Disease | Myeloproliferative disease;FunDO |
Disease | Height;NHGRI |
Disease | Leukemia, chronic myeloid;OMIM |
Disease | depressive disorder, major;GAD |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | CANCER;GAD |
Disease | Leukemia, acute lymphocytic;OMIM |
Disease | PSYCH;GAD |
Disease | thyroid cancer;GAD |
Disease | Congenital abnormality;FunDO |
Disease | Cerebrovascular disorder;FunDO |
Disease | Cancer;FunDO |
Disease | Chronic myeloid leukemia (CML);KEGG DISEASE;H00004 |
Disease | melanoma;GAD |
Disease | Bone marrow disease;FunDO |
Disease | bipolar disorder;GAD |
Disease | Acute lymphoblastic leukemia (ALL) (Precursor B lymphoblastic leukemia);KEGG DISEASE;H00001 |
Disease | height;GAD |
Disease | colorectal cancer;GAD |
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External Links |
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Links to Entrez Gene | 613 |
Links to all GeneRIF Items | 613 |
Links to iHOP | 613 |
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Sequence Information |
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Nucleotide Sequence |
>613 : length: 3816 atggtggacccggtgggcttcgcggaggcgtggaaggcgcagttcccggactcagagccc ccgcgcatggagctgcgctcagtgggcgacatcgagcaggagctggagcgctgcaaggcc tccattcggcgcctggagcaggaggtgaaccaggagcgcttccgcatgatctacctgcag acgttgctggccaaggaaaagaagagctatgaccggcagcgatggggcttccggcgcgcg gcgcaggcccccgacggcgcctccgagccccgagcgtccgcgtcgcgcccgcagccagcg cccgccgacggagccgacccgccgcccgccgaggagcccgaggcccggcccgacggcgag ggttctccgggtaaggccaggcccgggaccgcccgcaggcccggggcagccgcgtcgggg gaacgggacgaccggggaccccccgccagcgtggcggcgctcaggtccaacttcgagcgg atccgcaagggccatggccagcccggggcggacgccgagaagcccttctacgtgaacgtc gagtttcaccacgagcgcggcctggtgaaggtcaacgacaaagaggtgtcggaccgcatc agctccctgggcagccaggccatgcagatggagcgcaaaaagtcccagcacggcgcgggc tcgagcgtgggggatgcatccaggcccccttaccggggacgctcctcggagagcagctgc ggcgtcgacggcgactacgaggacgccgagttgaacccccgcttcctgaaggacaacctg atcgacgccaatggcggtagcaggcccccttggccgcccctggagtaccagccctaccag agcatctacgtcgggggcatgatggaaggggagggcaagggcccgctcctgcgcagccag agcacctctgagcaggagaagcgccttacctggccccgcaggtcctactccccccggagt tttgaggattgcggaggcggctataccccggactgcagctccaatgagaacctcacctcc agcgaggaggacttctcctctggccagtccagccgcgtgtccccaagccccaccacctac cgcatgttccgggacaaaagccgctctccctcgcagaactcgcaacagtccttcgacagc agcagtccccccacgccgcagtgccataagcggcaccggcactgcccggttgtcgtgtcc gaggccaccatcgtgggcgtccgcaagaccgggcagatctggcccaacgatggcgagggc gccttccatggagacgcagatggctcgttcggaacaccacctggatacggctgcgctgca gaccgggcagaggagcagcgccggcaccaagatgggctgccctacattgatgactcgccc tcctcatcgccccacctcagcagcaagggcaggggcagccgggatgcgctggtctcggga gccctggagtccactaaagcgagtgagctggacttggaaaagggcttggagatgagaaaa tgggtcctgtcgggaatcctggctagcgaggagacttacctgagccacctggaggcactg ctgctgcccatgaagcctttgaaagccgctgccaccacctctcagccggtgctgacgagt cagcagatcgagaccatcttcttcaaagtgcctgagctctacgagatccacaaggagttc tatgatgggctcttcccccgcgtgcagcagtggagccaccagcagcgggtgggcgacctc ttccagaagctggccagccagctgggtgtgtaccgggccttcgtggacaactacggagtt gccatggaaatggctgagaagtgctgtcaggccaatgctcagtttgcagaaatctccgag aacctgagagccagaagcaacaaagatgccaaggatccaacgaccaagaactctctggaa actctgctctacaagcctgtggaccgtgtgacgaggagcacgctggtcctccatgacttg ctgaagcacactcctgccagccaccctgaccaccccttgctgcaggacgccctccgcatc tcacagaacttcctgtccagcatcaatgaggagatcacaccccgacggcagtccatgacg gtgaagaagggagagcaccggcagctgctgaaggacagcttcatggtggagctggtggag ggggcccgcaagctgcgccacgtcttcctgttcaccgacctgcttctctgcaccaagctc aagaagcagagcggaggcaaaacgcagcagtatgactgcaaatggtacattccgctcacg gatctcagcttccagatggtggatgaactggaggcagtgcccaacatccccctggtgccc gatgaggagctggacgctttgaagatcaagatctcccagatcaagaatgacatccagaga gagaagagggcgaacaagggcagcaaggctacggagaggctgaagaagaagctgtcggag caggagtcactgctgctgcttatgtctcccagcatggccttcagggtgcacagccgcaac ggcaagagttacacgttcctgatctcctctgactatgagcgtgcagagtggagggagaac atccgggagcagcagaagaagtgtttcagaagcttctccctgacatccgtggagctgcag atgctgaccaactcgtgtgtgaaactccagactgtccacagcattccgctgaccatcaat aaggaagatgatgagtctccggggctctatgggtttctgaatgtcatcgtccactcagcc actggatttaagcagagttcaaatctgtactgcaccctggaggtggattcctttgggtat tttgtgaataaagcaaagacgcgcgtctacagggacacagctgagccaaactggaacgag gaatttgagatagagctggagggctcccagaccctgaggatactgtgctatgaaaagtgt tacaacaagacgaagatccccaaggaggacggcgagagcacggacagactcatggggaag ggccaggtccagctggacccgcaggccctgcaggacagagactggcagcgcaccgtcatc gccatgaatgggatcgaagtaaagctctcggtcaagttcaacagcagggagttcagcttg aagaggatgccgtcccgaaaacagacaggggtcttcggagtcaagattgctgtggtcacc aagagagagaggtccaaggtgccctacatcgtgcgccagtgcgtggaggagatcgagcgc cgaggcatggaggaggtgggcatctaccgcgtgtccggtgtggccacggacatccaggca ctgaaggcagccttcgacgtcaataacaaggacgtgtcggtgatgatgagcgagatggac gtgaacgccatcgcaggcacgctgaagctgtacttccgtgagctgcccgagcccctcttc actgacgagttctaccccaacttcgcagagggcatcgctctttcagacccggttgcaaag gagagctgcatgctcaacctgctgctgtccctgccggaggccaacctgctcaccttcctt ttccttctggaccacctgaaaagggtggcagagaaggaggcagtcaataagatgtccctg cacaacctcgccacggtctttggccccacgctgctccggccctccgagaaggagagcaag ctccctgccaaccccagccagcctatcaccatgactgacagctggtccttggaggtcatg tcccaggtccaggtgctgctgtacttcctgcagctggaggccatccctgccccggacagc aagagacagagcatcctgttctccaccgaagtctaa |
Protein Sequence |
>613 : length: 1271 MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVP DEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNE EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVI AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIER RGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLF TDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSL HNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDS KRQSILFSTEV |