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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 6389 |
Name | SDHA |
Synonym | CMD1GG|FP|PGL5|SDH1|SDH2|SDHF;succinate dehydrogenase complex, subunit A, flavoprotein (Fp);SDHA;succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
Definition | flavoprotein subunit of complex II|succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial|succinate dehydrogenase complex flavoprotein subunit |
Position | 5p15 |
Gene Type | protein-coding |
Source | Count: 2; Generif,UniProt |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
reviewed | SDHA is a tumor suppressor gene causing paraganglioma. |
| More detail of all 1 literatures about SDHA | |
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Pathways and Diseases |
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Pathway | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.;Reactome;REACT:6305 |
Pathway | Pyruvate metabolism and Citric Acid (TCA) cycle;Reactome;REACT:1046 |
Pathway | Citrate cycle (TCA cycle);KEGG PATHWAY;hsa00020 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Oxidative phosphorylation;KEGG PATHWAY;hsa00190 |
Pathway | TCA cycle variation III (eukaryotic);BioCyc;PWY-5690 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | Parkinson's disease;KEGG PATHWAY;hsa05012 |
Disease | Cardiomyopathy, dilated, 1GG;OMIM |
Disease | Leigh syndrome;OMIM |
Disease | Cancer;FunDO |
Disease | Mitochondrial respiratory chain complex II deficiency;OMIM |
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External Links |
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Links to Entrez Gene | 6389 |
Links to all GeneRIF Items | 6389 |
Links to iHOP | 6389 |
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Sequence Information |
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Nucleotide Sequence |
>6389 : length: 1995 atgtcgggggtccggggcctgtcgcggctgctgagcgctcggcgcctggcgctggccaag gcgtggccaacagtgttgcaaacaggaacccgaggttttcacttcactgttgatgggaac aagagggcatctgctaaagtttcagattccatttctgctcagtatccagtagtggatcat gaatttgatgcagtggtggtaggcgctggaggggcaggcttgcgagctgcatttggcctt tctgaggcagggtttaatacagcatgtgttaccaagctgtttcctaccaggtcacacact gttgcagcacagggaggaatcaatgctgctctggggaacatggaggaggacaactggagg tggcatttctacgacaccgtgaagggctccgactggctgggggaccaggatgccatccac tacatgacggagcaggcccccgccgccgtggtcgagctagaaaattatggcatgccgttt agcagaactgaagatgggaagatttatcagcgtgcatttggtggacagagcctcaagttt ggaaagggcgggcaggcccatcggtgctgctgtgtggctgatcggactggccactcgcta ttgcacaccttatatggaaggtctctgcgatatgataccagctattttgtggagtatttt gccttggatctcctgatggagaatggggagtgccgtggtgtcatcgcactgtgcatagag gacgggtccatccatcgcataagagcaaagaacactgttgttgccacaggaggctacggg cgcacctacttcagctgcacgtctgcccacaccagcactggcgacggcacggccatgatc accagggcaggccttccttgccaggacctagagtttgttcagttccaccctacaggcata tatggtgctggttgtctcattacggaaggatgtcgtggagagggaggcattctcattaac agtcaaggcgaaaggtttatggagcgatacgcccctgtcgcgaaggacctggcgtctaga gatgtggtgtctcggtccatgactctggagatccgagaaggaagaggctgtggccctgag aaagatcacgtctacctgcagctgcaccacctacctccagagcagctggccacgcgcctg cctggcatttcagagacagccatgatcttcgctggcgtggacgtcacgaaggagccgatc cctgtcctccccaccgtgcattataacatgggcggcattcccaccaactacaaggggcag gtcctgaggcacgtgaatggccaggatcagattgtgcccggcctgtacgcctgtggggag gccgcctgtgcctcggtacatggtgccaaccgcctcggggcaaactcgctcttggacctg gttgtctttggtcgggcatgtgccctgagcatcgaagagtcatgcaggcctggagataaa gtccctccaattaaaccaaacgctggggaagaatctgtcatgaatcttgacaaattgaga tttgctgatggaagcataagaacatcggaactgcgactcagcatgcagaagtcaatgcaa aatcatgctgccgtgttccgtgtgggaagcgtgttgcaagaaggttgtgggaaaatcagc aagctctatggagacctaaagcacctgaagacgttcgaccggggaatggtctggaacacg gacctggtggagaccctggagctgcagaacctgatgctgtgtgcgctgcagaccatctac ggagcagaggcacggaaggagtcacggggcgcgcatgccagggaagactacaaggtgcgg attgatgagtacgattactccaagcccatccaggggcaacagaagaagccctttgaggag cactggaggaagcacaccctgtcctatgtggacgttggcactgggaaggtcactctggaa tatagacccgtgatcgacaaaactttgaacgaggctgactgtgccaccgtcccgccagcc attcgctcctactga |
Protein Sequence |
>6389 : length: 664 MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDH EFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWR WHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKF GKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIE DGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGI YGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPE KDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQ VLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDK VPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKIS KLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVR IDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPA IRSY |