Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

6392

Name

SDHD

Synonym

CBT1|PGL|PGL1|SDH4;succinate dehydrogenase complex, subunit D, integral membrane protein;SDHD;succinate dehydrogenase complex, subunit D, integral membrane protein

Definition

CII-4|QPs3|cybS|succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial|succinate dehydrogenase complex subunit D|succinate dehydrogenase ubiquinone cytochrome B small subunit|succinate-ubiquinone oxidoreductase cytochrome b small s

Position

11q23

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 1 PubMed records as below.

Evidence Status

Description

potential

SDHD may have a role in colorectal and gastric cancers as a distinct type of tumor suppressor.
More detail of all 1 literatures about SDHD

Pathways and Diseases

Pathway

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.;Reactome;REACT:6305

Pathway

Pyruvate metabolism and Citric Acid (TCA) cycle;Reactome;REACT:1046

Pathway

Citrate cycle (TCA cycle);KEGG PATHWAY;hsa00020

Pathway

Metabolic pathways;KEGG PATHWAY;hsa01100

Pathway

Oxidative phosphorylation;KEGG PATHWAY;hsa00190

Pathway

TCA cycle variation III (eukaryotic);BioCyc;PWY-5690

Pathway

Alzheimer's disease;KEGG PATHWAY;hsa05010

Pathway

Respiratory electron transport;PID Reactome;500282

Pathway

Huntington's disease;KEGG PATHWAY;hsa05016

Pathway

Parkinson's disease;KEGG PATHWAY;hsa05012

Disease

Cowden-like syndrome;OMIM

Disease

Cancers;KEGG DISEASE

Disease

Paragangliomas, familial nonchromaffin, 1, with or without deafness;OMIM

Disease

pheochromocytomas;GAD

Disease

Merkel cell carcinoma, somatic;OMIM

Disease

Paraganglioma and gastric stromal sarcoma;OMIM

Disease

CANCER;GAD

Disease

Cancer;FunDO

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

paragangliomas, head and neck;GAD

Disease

Carcinoid;KEGG DISEASE;H00034

Disease

Pheochromocytoma;OMIM

Disease

Carcinoid tumors, intestinal;OMIM

Disease

Actinic keratosis;FunDO

External Links

Links to Entrez Gene

6392

Links to all GeneRIF Items

6392

Links to iHOP

6392

Sequence Information

Nucleotide Sequence

>6392 : length: 480
atggcggttctctggaggctgagtgccgtttgcggtgccctaggaggccgagctctgttg
cttcgaactccagtggtcagacctgctcatatctcagcatttcttcaggaccgacctatc
ccagaatggtgtggagtgcagcacatacacttgtcaccgagccaccattctggctccaag
gctgcatctctccactggactagcgagagggttgtcagtgttttgctcctgggtctgctt
ccggctgcttatttgaatccttgctctgcgatggactattccctggctgcagccctcact
cttcatggtcactggggccttggacaagttgttactgactatgttcatggggatgccttg
cagaaagctgccaaggcagggcttttggcactttcagctttaacctttgctgggctttgc
tatttcaactatcacgatgtgggcatctgcaaagctgttgccatgctgtggaagctctga

Protein Sequence

>6392 : length: 159
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSK
AASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDAL
QKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL



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