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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 65268 |
Name | WNK2 |
Synonym | NY-CO-43|P/OKcl.13|PRKWNK2|SDCCAG43;WNK lysine deficient protein kinase 2;WNK2;WNK lysine deficient protein kinase 2 |
Definition | antigen NY-CO-43|mitogen-activated protein kinase kinase kinase|protein kinase lysine-deficient 2|protein kinase with no lysine 2|protein kinase, lysine deficient 2|serine/threonine-protein kinase WNK2|serologically defined colon cancer antigen 43 |
Position | 9q22.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. |
| More detail of all 1 literatures about WNK2 | |
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External Links |
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Links to Entrez Gene | 65268 |
Links to all GeneRIF Items | 65268 |
Links to iHOP | 65268 |
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Sequence Information |
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Nucleotide Sequence |
>65268 : length: 6654 atggacggcgatggcggccgccgagacgtccccggcacgctgatggagcccgggcgcggc gcggggcccgcgggcatggcggagcctcgggcgaaggcggcgcggccggggccccagcgc tttctgcggcgcagcgtggtagagtcggaccaggaggagccgccgggcttggaggcagcc gaggcgccgggcccgcagcccccgcagcccctgcagcgccgggtgcttctgctctgcaag acgcgccgcctcatcgcggagcgcgcccgcggacgccccgccgcccccgcgcccgcagcg ctggtagcgcagccgggagcccccggagcccccgcggacgccggccccgagcccgtgggc acgcaggagcccggcccggaccccatcgcagccgctgtcgaaaccgcgcctgcccccgac ggcggccccagggaggaggcggcggcgaccgtgaggaaggaggatgagggggcggccgag gcgaagcctgagcccgggcgcactcgccgggacgagcccgaagaggaggaggacgacgag gacgacctcaaggccgtggccacctctctggacggccgcttcctcaagttcgacatcgag ctgggccgcggttccttcaagacggtctacaaggggctggacacggagacctgggtggag gtggcctggtgtgagctgcaggaccggaagctcaccaagctggagcggcagcggttcaag gaagaggctgagatgctgaaaggcctgcagcaccccaacatcgtgcgcttctacgacttc tgggagtccagcgccaagggcaagcggtgcattgtgctggtgacggagctgatgacctca gggacgctgaagacatacctgaagcggttcaaggtgatgaagcccaaggttctccgcagc tggtgccggcagatcctgaagggcctgctgttcctgcacacaaggacgccacccatcatc caccgagacctgaaatgtgacaatattttcatcaccggaccaactgggtctgtgaagatt ggcgacttgggcctggccactctgaaaagagcgtcatttgccaaaagtgtgataggtact cccgagttcatggcgcccgagatgtacgaggagcactacgatgagtccgtggacgtctat gcctttgggatgtgcatgctggagatggccacctcggagtacccctactcggagtgccag aatgcggcccagatctaccgcaaggtcacctgtggtatcaagccggccagctttgagaaa gtgcacgatcctgaaatcaaggagattattggggagtgtatctgcaaaaacaaggaggaa aggtacgagatcaaagacctgctgagccacgccttcttcgcagaggacacaggcgtgagg gtggagctcgcggaggaggaccacggcaggaagtccaccatcgccctgaggctctgggtg gaagaccccaagaaactgaagggaaagcccaaggacaatggagccatagagttcaccttc gacctggagaaggagacgccggatgaggtggcccaagagatgattgagtctggattcttc cacgagagtgacgtcaagatcgtggccaagtccatccgtgaccgcgtggccttgatccag tggcggcgggagaggatctggcccgcgctgcagcccaaggagcagcaggatgtgggcagc ccggacaaggccaggggtccgccggtgcccctgcaggtccaggtgacctaccatgcacag gctgggcagcccgggccaccagagcccgaggagccggaggccgaccagcacctcctgcca cctacgttgccgaccagcgccacctccctggcctcggacagcaccttcgacagcggccag ggctctaccgtgtactcagactcgcagagcagccagcagagcgtgatgcttggctccctt gccgacgcagcgccgtccccggcccagtgtgtgtgcagcccccctgtgagcgaggggccc gtcctgccgcagagcctgccctcgctgggggcctaccagcagcccacggctgcacctggc ttgccggtgggctctgtcccggcccccgcctgccctccgtccctccagcagcacttcccg gatccggccatgagcttcgcccccgtgctgccgccgcccagcacccccatgcccacgggc ccaggccagccagcaccccccggccagcagcctcctccgctggcccagccgacacccctg ccgcaggtcctggccccacagcccgtggtccccctccagccggttcccccccacctgcca ccgtacctggctccagcctcccaggtgggggcccccgctcagctgaagcccctccagatg ccacaggcgcccctgcagccgcttgctcaagtccctccgcagatgcccccgattcctgtt gtgccccccatcacgcccctggcgggaatcgacggcctccctccggccctcccagacctg ccgaccgcgactgtgcctcccgtgccaccacctcagtatttctctccagccgtgatcttg ccgagcctcgctgccccactcccccctgcgtccccagccttgcctctgcaggctgtgaag ctgccccacccccctggggcgcccctggccatgccctgccggaccattgtgccaaatgca ccggccactatccccctgctggccgtagccccaccgggcgtggctgccctgtccattcat tctgccgtggcccagctcccaggccaacctgtgtacccagcggccttcccacagatggcg cctactgacgtccctccttccccccatcacacggtgcagaatatgagggccacccctcca cagccggcactgcctccacaacccacactgcccccacaacccgtgctgcccccgcaaccc acgctgccccctcaacctgtgttgcccccgcaacccacacggccccctcaacctgtgctg cccccgcaacccatgctgcccccacaacctgtgctgcccccgcagccggcactgcctgtg cgccctgagcccctccagccccaccttcctgaacaagctgctccagctgctacaccaggg agccagattctgcttggccacccagctccctatgctgtggacgtcgccgctcaggtcccc accgtgcctgtgccaccggctgcggtcctctcgccgcctctgccggaagtgctgctgcct gccgcccctgagctcctgcctcagttccccagctccctggccacggtgtctgcctctgtg cagagtgtgcccacccagactgccacacttctgccaccagcaaacccaccgctgcctggc gggcccgggatcgccagcccttgcccaactgtccagctgacggtggaaccagtccaagag gagcaggcctcacaggacaagccgcccggcctcccgcagagctgtgagagctatggaggt tctgatgtcacttctggaaaagagctgagtgacagctgtgaaggcgcctttggagggggc aggctggagggcagggcagcccgaaaacaccaccgcaggtccacgcgtgcgcgctcccgg caggagagggccagccggccccggcttaccatcttgaacgtgtgcaacactggggacaag atggtggagtgccagctggagacgcacaaccacaagatggtgaccttcaagttcgacttg gacggggacgcacccgatgaaattgccacgtatatggtggagcatgactttatcctgcag gccgagcgggaaacgttcatcgagcagatgaaggatgtcatggacaaggcagaggacatg ctcagcgaggacacagacgccgaccgtggctccgacccagggaccagcccgccacacctc agcacctgcggcctgggcaccggggaggagagccgacaatcccaagccaacgcccccgtg tatcagcagaacgtcctgcacaccgggaagaggtggttcatcatctgtccggtggctgag caccccgcccccgaggcccctgaatcttcgcccccacttcctctaagctccctgccgcca gaagccagccaagattcagcgccctataaagaccagctgtcctcgaaggaacaacccagc tttctagccagtcagcagctcctgagccaggcgggccccagcaaccctcctggggcaccc ccagcccctttggccccctcctcccctcctgtgactgctctgccccaagatggagcagct ccagccaccagcaccatgccagagccagcgtcaggaactgccagccaggcagggggtcca gggacacctcaggggctgaccagtgagctcgagacgtctcagccactagcggagactcac gaggccccgcttgctgtgcagcccctcgtggtgggcctagcaccttgcactccagctcca gaggctgcctcaaccagggacgccagtgccccaagggagcccctgccacctcctgcacct gagcccagcccccacagcgggaccccacagcccgccttgggtcaacctgctcccctgctt cctgccgcagtgggggccgtcagcctggccacctcccagctcccaagcccacccctgggg cccaccgtccccccacagccaccctcggccctggagtcggatggggaagggccgcccccc agggtgggctttgtggacagcaccatcaagagcctggacgagaagctgcggactctgctc taccaggagcacgtgcccacctcctcagcctcagctgggacccctgtggaggtgggcgac agagacttcaccctggagcccctgagaggggaccagccccgctcagaggtctgcgggggg gacctggccctgcccccagtgcctaaggaggcggtctcagggcgtgtccagctgccccag cccttggtggagaagtcagaactggcccccactcgaggggccgtgatggagcagggcacg tcctcgtcaatgacagcagagtcgtctcccaggagtatgctaggctatgacagagatgga aggcaggtggcctcagactcccatgtggtccccagcgtcccccaggatgtacctgctttt gtgagacctgcacgtgtggagcccacagacagggatggtggagaagctggagaaagctcg gcagagcccccgccgagtgacatgggcacagtggggggccaggctagccacccccagaca ctcggcgctcgagctttggggtcccctcggaaacgtccagagcagcaggatgtcagctca ccagccaagactgtgggccgtttctcggtggtcagcactcaggacgagtggaccctggcc tccccccacagcctgagatactctgccccacccgacgtctacctggacgaggccccctcc agccccgacgtgaagctggcagtgcggcgggcgcagacggcctcctccatcgaggtcggc gtgggcgagcccgtgtccagcgactctggggacgagggccctcgggcgagacccccggtg cagaagcaggcgtccctgcccgtgagtggcagcgtggctggcgacttcgtgaagaaggcc accgccttcctgcagaggccttctcgggccggctcgctgggccccgagacacccagcagg gtgggcatgaaggtccccacgatcagcgtgacctccttccattcccagtcgtcctacatc agcagcgacaatgattcggagctcgaggatgctgacataaagaaggagctgcagagtctg cgggagaagcacctgaaggagatctcggagctgcagagccagcagaagcaggagatcgaa gctctgtaccgccgcctgggcaagccactgccccccaacgtgggcttcttccacacggca ccccccactggccgccggagaaaaaccagcaagagcaagctgaaggcaggcaagctgcta aatcccctggtgcggcagctcaaggtcgtggcctccagcacaggtcacttggctgactcc agcagaggccctcccgctaaggaccctgcccaagccagtgtggggctcactgcagacagc acgggcctgagcgggaaggcagtgcagacccagcagccctgctccgtccgggcctccctg tcttcggacatctgctccggcttagccagtgatggaggcggagcgcgtggccaaggctgg acggtttaccacccaacgtctgagagagtgacctataagtctagtagcaaacctcgtgct cgattcctcagtggacccgtatctgtgtccatctggtctgccctgaagcgtctctgccta ggcaaagaacacagcagtaggtcctccaccagcagcctggccccaggccctgagccaggc ccccagcccgccctgcacgtccaggcgcaggtgaacaacagcaacaacaagaagggtacc ttcacggacgacctgcacaagctggtggacgagtggacgagcaagacggtgggggccgcg cagctgaagcccacgctcaaccagctgaagcagacccagaagctgcaagacatggaggcc caggcaggctgggctgcccctggcgaggcgcgggctatgaccgcacctcgagcaggagtg gggatgccacgtctgcccccagcgcccggccctctgtccaccacggtcattcccggagcc gccccgaccctgtccgtgcccacaccagatcctgagagtgagaagcctgactga |
Protein Sequence |
>65268 : length: 2217 MDGDGGRRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAA EAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVG TQEPGPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRRDEPEEEEDDE DDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFK EEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRS WCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGT PEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEK VHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWV EDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQ WRRERIWPALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLP PTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGP VLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTG PGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQM PQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVIL PSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIH SAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQP TLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPG SQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASV QSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGG SDVTSGKELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDK MVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDM LSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAE HPAPEAPESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAP PAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETH EAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLL PAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLL YQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQ PLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAF VRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSS PAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVG VGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSR VGMKVPTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIE ALYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADS SRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGW TVYHPTSERVTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPG PQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEA QAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDPESEKPD |