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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6925 |
Name | TCF4 |
Synonym | E2-2|ITF-2|ITF2|PTHS|SEF-2|SEF2|SEF2-1|SEF2-1A|SEF2-1B|TCF-4|bHLHb19;transcription factor 4;TCF4;transcription factor 4 |
Definition | SL3-3 enhancer factor 2|class B basic helix-loop-helix protein 19|immunoglobulin transcription factor 2 |
Position | 18q21.1 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | This data support the notion that the ITF2 gene on chromosome 18q is a tumor suppressor gene. |
reviewed | ITF-2B is a tumor suppressor that has an important function at the adenoma to carcinoma transition. |
| More detail of all 2 literatures about TCF4 | |
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Pathways and Diseases |
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Pathway | Coregulation of Androgen receptor activity;PID Curated;200038 |
Pathway | Myogenesis;Reactome;REACT:21303 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Disease | Fuch's corneal dystrophy;NHGRI |
Disease | Pitt-Hopkins syndrome;OMIM |
Disease | PSYCH;GAD |
Disease | Schizophrenia;NHGRI |
Disease | schizophrenia;GAD |
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External Links |
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Links to Entrez Gene | 6925 |
Links to all GeneRIF Items | 6925 |
Links to iHOP | 6925 |
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Sequence Information |
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Nucleotide Sequence |
>6925 : length: 2016 atgcatcaccaacagcgaatggctgccttagggacggacaaagagctgagtgatttactg gatttcagtgcgatgttttcacctcctgtgagcagtgggaaaaatggaccaacttctttg gcaagtggacattttactggctcaaatgtagaagacagaagtagctcagggtcctggggg aatggaggacatccaagcccgtccaggaactatggagatgggactccctatgaccacatg accagcagggaccttgggtcacatgacaatctctctccaccttttgtcaattccagaata caaagtaaaacagaaaggggctcatactcatcttatgggagagaatcaaacttacagggt tgccaccagcagagtctccttggaggtgacatggatatgggcaacccaggaaccctttcg cccaccaaacctggttcccagtactatcagtattctagcaataatccccgaaggaggcct cttcacagtagtgccatggaggtacagacaaagaaagttcgaaaagttcctccaggtttg ccatcttcagtctatgctccatcagcaagcactgccgactacaatagggactcgccaggc tatccttcctccaaaccagcaaccagcactttccctagctccttcttcatgcaagatggc catcacagcagtgacccttggagctcctccagtgggatgaatcagcctggctatgcagga atgttgggcaactcttctcatattccacagtccagcagctactgtagcctgcatccacat gaacgtttgagctatccatcacactcctcagcagacatcaattccagtcttcctccgatg tccactttccatcgtagtggtacaaaccattacagcacctcttcctgtacgcctcctgcc aacgggacagacagtataatggcaaatagaggaagcggggcagccggcagctcccagact ggagatgctctggggaaagcacttgcttcgatctattctccagatcacactaacaacagc ttttcatcaaacccttcaactcctgttggctctcctccatctctctcagcaggcacagct gtttggtctagaaatggaggacaggcctcatcgtctcctaattatgaaggacccttacac tctttgcaaagccgaattgaagatcgtttagaaagactggatgatgctattcatgttctc cggaaccatgcagtgggcccatccacagctatgcctggtggtcatggggacatgcatgga atcattggaccttctcataatggagccatgggtggtctgggctcagggtatggaaccggc cttctttcagccaacagacattcactcatggtggggacccatcgtgaagatggcgtggcc ctgagaggcagccattctcttctgccaaaccaggttccggttccacagcttcctgtccag tctgcgacttcccctgacctgaacccaccccaggacccttacagaggcatgccaccagga ctacaggggcagagtgtctcctctggcagctctgagatcaaatccgatgacgagggtgat gagaacctgcaagacacgaaatcttcggaggacaagaaattagatgacgacaagaaggat atcaaatcaattactaggtcaagatctagcaataatgacgatgaggacctgacaccagag cagaaggcagagcgtgagaaggagcggaggatggccaacaatgcccgagagcgtctgcgg gtccgtgacatcaacgaggctttcaaagagctcggccgcatggtgcagctccacctcaag agtgacaagccccagaccaagctcctgatcctccaccaggcggtggccgtcatcctcagt ctggagcagcaagtccgagaaaggaatctgaatccgaaagctgcgtgtctgaaaagaagg gaggaagagaaggtgtcctcagagcctccccctctctccttggccggcccacaccctgga atgggagacgcatcgaatcacatgggacagatgtaa |
Protein Sequence |
>6925 : length: 671 MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWG NGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQG CHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGL PSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPA NGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHG IIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQ SATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKD IKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLK SDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPG MGDASNHMGQM |