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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 7056 |
Name | THBD |
Synonym | AHUS6|BDCA3|CD141|THRM|TM;thrombomodulin;THBD;thrombomodulin |
Definition | CD141 antigen|fetomodulin |
Position | 20p11.2 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | "TM, a novel downstream target of Snail in epithelial-mesenchymal transition, is required for maintaining epithelial morphology and functions as a tumor suppressor." |
| More detail of all 1 literatures about THBD | |
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Pathways and Diseases |
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Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | Common Pathway;PID Reactome;500303 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2;PID Curated;200044 |
Pathway | Hemostasis;Reactome;REACT:604 |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | Thrombophilia due to thrombomodulin defect;OMIM |
Disease | atherosclerosis, coronary;GAD |
Disease | cerebral infarct;GAD |
Disease | thrombosis, deep vein;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | acute myocardial infarction;GAD |
Disease | Myocardial Infarction;GAD |
Disease | Hemolytic uremic syndrome, atypical, susceptibility to, 6;OMIM |
Disease | Atherosclerosis;GAD |
Disease | Myocardial infarction, susceptibility to;OMIM |
Disease | Inherited thrombophilia;KEGG DISEASE;H00223 |
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External Links |
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Links to Entrez Gene | 7056 |
Links to all GeneRIF Items | 7056 |
Links to iHOP | 7056 |
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Sequence Information |
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Nucleotide Sequence |
>7056 : length: 1728 atgcttggggtcctggtccttggcgcgctggccctggccggcctggggttccccgcaccc gcagagccgcagccgggtggcagccagtgcgtcgagcacgactgcttcgcgctctacccg ggccccgcgaccttcctcaatgccagtcagatctgcgacggactgcggggccacctaatg acagtgcgctcctcggtggctgccgatgtcatttccttgctactgaacggcgacggcggc gttggccgccggcgcctctggatcggcctgcagctgccacccggctgcggcgaccccaag cgcctcgggcccctgcgcggcttccagtgggttacgggagacaacaacaccagctatagc aggtgggcacggctcgacctcaatggggctcccctctgcggcccgttgtgcgtcgctgtc tccgctgctgaggccactgtgcccagcgagccgatctgggaggagcagcagtgcgaagtg aaggccgatggcttcctctgcgagttccacttcccagccacctgcaggccactggctgtg gagcccggcgccgcggctgccgccgtctcgatcacctacggcaccccgttcgcggcccgc ggagcggacttccaggcgctgccggtgggcagctccgccgcggtggctcccctcggctta cagctaatgtgcaccgcgccgcccggagcggtccaggggcactgggccagggaggcgccg ggcgcttgggactgcagcgtggagaacggcggctgcgagcacgcgtgcaatgcgatccct ggggctccccgctgccagtgcccagccggcgccgccctgcaggcagacgggcgctcctgc accgcatccgcgacgcagtcctgcaacgacctctgcgagcacttctgcgttcccaacccc gaccagccgggctcctactcgtgcatgtgcgagaccggctaccggctggcggccgaccaa caccggtgcgaggacgtggatgactgcatactggagcccagtccgtgtccgcagcgctgt gtcaacacacagggtggcttcgagtgccactgctaccctaactacgacctggtggacggc gagtgtgtggagcccgtggacccgtgcttcagagccaactgcgagtaccagtgccagccc ctgaaccaaactagctacctctgcgtctgcgccgagggcttcgcgcccattccccacgag ccgcacaggtgccagatgttttgcaaccagactgcctgtccagccgactgcgaccccaac acccaggctagctgtgagtgccctgaaggctacatcctggacgacggtttcatctgcacg gacatcgacgagtgcgaaaacggcggcttctgctccggggtgtgccacaacctccccggt accttcgagtgcatctgcgggcccgactcggcccttgcccgccacattggcaccgactgt gactccggcaaggtggacggtggcgacagcggctctggcgagcccccgcccagcccgacg cccggctccaccttgactcctccggccgtggggctcgtgcattcgggcttgctcataggc atctccatcgcgagcctgtgcctggtggtggcgcttttggcgctcctctgccacctgcgc aagaagcagggcgccgccagggccaagatggagtacaagtgcgcggccccttccaaggag gtagtgctgcagcacgtgcggaccgagcggacgccgcagagactctga |
Protein Sequence |
>7056 : length: 575 MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL |