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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 7157 |
Name | TP53 |
Synonym | LFS1|P53|TRP53;tumor protein p53;TP53;tumor protein p53 |
Definition | antigen NY-CO-13|cellular tumor antigen p53|p53 tumor suppressor|phosphoprotein p53|transformation-related protein 53|tumor suppressor TP53 |
Position | 17p13.1 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 163 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Cancerous tissues from 30 patients with HPSCC were examined for LOH in 4 tumor suppressor genes (TSGs) (p16, Rb, E-cadherin, and p53) at loci 9p21, 13q21, 6q22, and 17p13, respectively, using microsatellite markers amplified by polymerase chain reaction." |
reviewed | threshold for loss of tumor suppressor activity in terms of the disruption of the tetrameric structure of p53 could be extremely low. |
reviewed | Somatic inactivating mutations of the tumor suppressor gene TP53 is associated with a group of aggressive adrenocortical cancers. |
reviewed | study demonstrates that intermittently sun-exposed skin contains an extensive number of phenotypically intact cell compartments bearing missense and nonsense mutations in the p53 tumor suppressor gene. |
reviewed | "Studies indicate that p53 regulates cellular metabolism, autophagy and many unconventional tumor suppressor activities." |
| More detail of all 163 literatures about TP53 | |
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Pathways and Diseases |
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Pathway | estrogen responsive protein efp controls cell cycle and breast tumors growth;PID BioCarta;100182 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | BARD1 signaling events;PID Curated;200174 |
Pathway | PLK3 signaling events;PID Curated;200186 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | regulation of transcriptional activity by pml;PID BioCarta;100067 |
Pathway | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha;PID Curated;200122 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | btg family proteins and cell cycle regulation;PID BioCarta;100224 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | apoptotic signaling in response to dna damage;PID BioCarta;100204 |
Pathway | cell cycle: g2/m checkpoint;PID BioCarta;100159 |
Pathway | Transcriptional activation of cell cycle inhibitor p21;PID Reactome;501023 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | P53 pathway feedback loops 1;PANTHER;P04392 |
Pathway | Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014 |
Pathway | tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Signaling mediated by p38-alpha and p38-beta;PID Curated;200154 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | atm signaling pathway;PID BioCarta;100235 |
Pathway | Validated targets of C-MYC transcriptional activation;PID Curated;200045 |
Pathway | rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | LKB1 signaling events;PID Curated;200061 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Autodegradation of the E3 ubiquitin ligase COP1;PID Reactome;500317 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | hypoxia and p53 in the cardiovascular system;PID BioCarta;100084 |
Pathway | p53 signaling pathway;PID BioCarta;100083 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | double stranded rna induced gene expression;PID BioCarta;100040 |
Pathway | p53 pathway by glucose deprivation;PANTHER;P04397 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | AP-1 transcription factor network;PID Curated;200118 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Aurora A signaling;PID Curated;200166 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Huntington disease;PANTHER;P00029 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Thyroid cancer;KEGG PATHWAY;hsa05216 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234 |
Pathway | Stabilization of p53;PID Reactome;500316 |
Pathway | telomeres telomerase cellular aging and immortality;PID BioCarta;100021 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | overview of telomerase protein component gene htert transcriptional regulation;PID BioCarta;100019 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | chaperones modulate interferon signaling pathway;PID BioCarta;100016 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Disease | Colorectal cancer;KEGG DISEASE;H00020 |
Disease | Thyroid cancer;KEGG DISEASE;H00032 |
Disease | tumour progression;GAD |
Disease | Adrenal carcinoma;KEGG DISEASE;H00033 |
Disease | Colorectal cancer;OMIM |
Disease | squamous cell carcinoma;GAD |
Disease | tumor progression of BCR/ABL negative chronic myeloproliferative disorders;GAD |
Disease | Bladder cancer;KEGG DISEASE;H00022 |
Disease | Leukemia, Myeloid, Acute;GAD |
Disease | Xeroderma pigmentosum;GAD |
Disease | Skin cancers;KEGG DISEASE |
Disease | aggressive behavior of chondrosarcoma;GAD |
Disease | albuminuria among aboriginal Australians;GAD |
Disease | brain tumors;GAD |
Disease | Osteosarcoma;KEGG DISEASE;H00036 |
Disease | IMMUNE;GAD |
Disease | Breast cancer;OMIM |
Disease | Viral infections;KEGG DISEASE |
Disease | ring sideroblasts;GAD |
Disease | Hairy-cell leukemia;KEGG DISEASE;H00006 |
Disease | PSYCH;GAD |
Disease | Non-small cell lung cancer;KEGG DISEASE;H00014 |
Disease | metastases;GAD |
Disease | colorectal adenocarcinomas;GAD |
Disease | Penile cancer;KEGG DISEASE;H00025 |
Disease | Li-Fraumeni syndrome;OMIM |
Disease | decreased chemosensitivity;GAD |
Disease | Cancers of the nervous system;KEGG DISEASE |
Disease | Small cell lung cancer;KEGG DISEASE;H00013 |
Disease | Head and neck squamous cell cancer;GAD |
Disease | Malignant melanoma;KEGG DISEASE;H00038 |
Disease | Burkitt lymphoma;KEGG DISEASE;H00008 |
Disease | smoking;GAD |
Disease | Neoplasms;GAD |
Disease | cerebral infarct, atherothrombotic;GAD |
Disease | skin carcinomas;GAD |
Disease | increased aggressiveness;GAD |
Disease | Pancreatic cancer;KEGG DISEASE;H00019 |
Disease | tumor proliferation and other prognostic indicators;GAD |
Disease | cervical cancer ovarian cancer;GAD |
Disease | Infections caused by retro-transcribing viruses;KEGG DISEASE |
Disease | hepatitis C virus infection;GAD |
Disease | Multiple myeloma;KEGG DISEASE;H00010 |
Disease | Vulvar cancer;KEGG DISEASE;H00029 |
Disease | Cancer of the anal canal;KEGG DISEASE;H00044 |
Disease | breast cancer by the age of 50 years;GAD |
Disease | prostate cancer;GAD |
Disease | Li-Fraumeni-like syndrome;OMIM |
Disease | Glioblastoma;GAD |
Disease | Breast cancer;KEGG DISEASE;H00031 |
Disease | Lung Neoplasms;GAD |
Disease | Adrenal cortical carcinoma;OMIM |
Disease | Endometrial cancer;KEGG DISEASE;H00026 |
Disease | increased lung cancer risk;GAD |
Disease | Adult T-cell leukemia;KEGG DISEASE;H00009 |
Disease | Lymphoma, Large B-Cell, Diffuse;GAD |
Disease | Cancers of the urinary system and male genital organs;KEGG DISEASE |
Disease | liver cancer;GAD |
Disease | CANCER;GAD |
Disease | Esophageal cancer;KEGG DISEASE;H00017 |
Disease | chronic obstructive pulmonary disease/COPD;GAD |
Disease | Kaposi's sarcoma;KEGG DISEASE;H00041 |
Disease | endometrial cancer;GAD |
Disease | Osteosarcoma;OMIM |
Disease | ulcerative colitis;GAD |
Disease | ovarian carcinoma;GAD |
Disease | Pancreatic cancer;OMIM |
Disease | sensitivity to TZT-1027;GAD |
Disease | Basal cell carcinoma;KEGG DISEASE;H00039 |
Disease | mucosa-associated lymphoid tissue lymphoma;GAD |
Disease | metastatic progression and poor survival;GAD |
Disease | Choroid plexus papilloma;OMIM |
Disease | progression of a prostate carcinoma;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Choriocarcinoma;KEGG DISEASE;H00028 |
Disease | METABOLIC;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Malignant pleural mesothelioma;KEGG DISEASE;H00015 |
Disease | colorectal cancer;GAD |
Disease | soft tissue sarcoma;GAD |
Disease | gastric cancer;GAD |
Disease | Hepatocellular carcinoma;KEGG DISEASE;H00048 |
Disease | Ovarian cancer;KEGG DISEASE;H00027 |
Disease | Leukemia, Lymphocytic, Chronic, B-Cell;GAD |
Disease | pancreatic adenocarcinoma;GAD |
Disease | Laryngeal cancer;KEGG DISEASE;H00055 |
Disease | Squamous cell carcinoma;KEGG DISEASE;H00040 |
Disease | INFECTION;GAD |
Disease | betel-quid chewing;GAD |
Disease | Cancers;KEGG DISEASE |
Disease | non-small cell lung carcinoma;GAD |
Disease | breast cancer;GAD |
Disease | ovarian cancer;GAD |
Disease | stomach cancer;GAD |
Disease | Cholangiocarcinoma;KEGG DISEASE;H00046 |
Disease | Gastric cancer;KEGG DISEASE;H00018 |
Disease | Cancers of the lung and pleura;KEGG DISEASE |
Disease | Cancers of soft tissues and bone;KEGG DISEASE |
Disease | breast carcinoma;GAD |
Disease | Nasopharyngeal carcinoma;OMIM |
Disease | Chronic myeloid leukemia (CML);KEGG DISEASE;H00004 |
Disease | colorectal cancers;GAD |
Disease | bladder cancer;GAD |
Disease | Hepatocellular carcinoma;OMIM |
Disease | non-small cell lung cancer;GAD |
Disease | lung cancer;GAD |
Disease | cervical cancer;GAD |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | Cancers of endocrine organs;KEGG DISEASE |
Disease | DNA Damage;GAD |
Disease | oesophageal squamous cell carcinoma;GAD |
Disease | psoriatic arthritis;GAD |
Disease | malignant myeloid disorders;GAD |
Disease | esophageal cancer;GAD |
Disease | breast cancer survival;GAD |
Disease | malignant cystosarcoma phyllodes and soft tissue sarcoma;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Chronic lymphocytic leukemia (CLL);KEGG DISEASE;H00005 |
Disease | Oral cancer;KEGG DISEASE;H00016 |
Disease | Infections caused by dsDNA viruses;KEGG DISEASE |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | keloid;GAD |
Disease | Gallbladder cancer;KEGG DISEASE;H00047 |
Disease | gastritis, chronic atrophic;GAD |
Disease | Glioma;KEGG DISEASE;H00042 |
Disease | alpha-particle carcinogenesis;GAD |
Disease | Head and neck cancers;KEGG DISEASE |
Disease | Brain Neoplasms;GAD |
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External Links |
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Links to Entrez Gene | 7157 |
Links to all GeneRIF Items | 7157 |
Links to iHOP | 7157 |
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Sequence Information |
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Nucleotide Sequence |
>7157 : length: 1182 atggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttca gacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatg gatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtcca gatgaagctcccagaatgccagaggctgctccccccgtggcccctgcaccagcagctcct acaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccag aaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaag tctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacc tgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatg gccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgag cgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaat ttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctat gagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagt tcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactcc agtggtaatctactgggacggaacagctttgaggtgcgtgtttgtgcctgtcctgggaga gaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgccc ccagggagcactaagcgagcactgcccaacaacaccagctcctctccccagccaaagaag aaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatg ttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggg gggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccat aaaaaactcatgttcaagacagaagggcctgactcagactga |
Protein Sequence |
>7157 : length: 393 MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD |