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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7345 |
Name | UCHL1 |
Synonym | PARK5|PGP 9.5|PGP9.5|PGP95|Uch-L1;ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase);UCHL1;ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
Definition | neuron cytoplasmic protein 9.5|ubiquitin C-terminal hydrolase|ubiquitin carboxyl-terminal hydrolase isozyme L1|ubiquitin thioesterase L1 |
Position | 4p14 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | Epigenetic inactivation of UCHL1 is common in primary hepatocellular carcinomas(HCCs) and other digestive tumors and appears to be functional tumor suppressor involved in tumorigenesis of HCCs and other digestive cancers. |
reviewed | PGP9.5 is a tumor suppressor gene that is inactivated by promoter methylation or gene deletion in several types of human cancers. |
| More detail of all 2 literatures about UCHL1 | |
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Pathways and Diseases |
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Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | Parkinson's disease;KEGG PATHWAY;hsa05012 |
Pathway | Parkinson disease;PANTHER;P00049 |
Disease | Parkinson's disease;KEGG DISEASE;H00057 |
Disease | Embryoma;FunDO |
Disease | Parkinson disease 5, susceptibility to;OMIM |
Disease | Renal Cell cancer;FunDO |
Disease | Alzheimer's disease;GAD |
Disease | Parkinson's disease;GAD |
Disease | Parkinson disease, resistance to;OMIM |
Disease | Lung cancer;FunDO |
Disease | Lysosomal storage disease;FunDO |
Disease | Nervous system diseases;KEGG DISEASE |
Disease | NEUROLOGICAL;GAD |
Disease | Neurodegenerative diseases;KEGG DISEASE |
Disease | Yersinia infection;FunDO |
Disease | Colon cancer;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | Huntington's disease;GAD |
Disease | Parkinson disease;FunDO |
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External Links |
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Links to Entrez Gene | 7345 |
Links to all GeneRIF Items | 7345 |
Links to iHOP | 7345 |
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Sequence Information |
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Nucleotide Sequence |
>7345 : length: 672 atgcagctcaagccgatggagatcaaccccgagatgctgaacaaagtgctgtcccggctg ggggtcgccggccagtggcgcttcgtggacgtgctggggctggaagaggagtctctgggc tcggtgccagcgcctgcctgcgcgctgctgctgctgtttcccctcacggcccagcatgag aacttcaggaaaaagcagattgaagagctgaagggacaagaagttagtcctaaagtgtac ttcatgaagcagaccattgggaattcctgtggcacaatcggacttattcacgcagtggcc aataatcaagacaaactgggatttgaggatggatcagttctgaaacagtttctttctgaa acagagaaaatgtcccctgaagacagagcaaaatgctttgaaaagaatgaggccatacag gcagcccatgatgccgtggcacaggaaggccaatgtcgggtagatgacaaggtgaatttc cattttattctgtttaacaacgtggatggccacctctatgaacttgatggacgaatgcct tttccggtgaaccatggcgccagttcagaggacaccctgctgaaggacgctgccaaggtc tgcagagaattcaccgagcgtgagcaaggagaagtccgcttctctgccgtggctctctgc aaggcagcctaa |
Protein Sequence |
>7345 : length: 223 MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA |