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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 7474 |
Name | WNT5A |
Synonym | hWNT5A;wingless-type MMTV integration site family, member 5A;WNT5A;wingless-type MMTV integration site family, member 5A |
Definition | WNT-5A protein|protein Wnt-5a |
Position | 3p21-p14 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Results suggest that Wnt5a plays the role of a tumor suppressor in leukemogenesis through the Wnt5a/Ror2 noncanonical signaling pathway that inhibits Wnt canonical signaling. |
potential | Results suggest that Wnt5a plays the role of a tumor suppressor in leukemogenesis through the Wnt5a/Ror2 noncanonical signaling pathway that inhibits Wnt canonical signaling. |
potential | "WNT5A, a putative tumor suppressor gene in acute myeloid leukemia (AML), is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression." |
reviewed | Wnt-5a serves as an antagonist to the canonical Wnt-signaling pathway with tumor suppressor activity in differentiated thyroid carcinomas. |
reviewed | Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. |
| More detail of all 4 literatures about WNT5A | |
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Pathways and Diseases |
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Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Hedgehog signaling pathway;KEGG PATHWAY;hsa04340 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | Noncanonical Wnt signaling pathway;PID Curated;200016 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Wnt signaling network;PID Curated;200055 |
Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Disease | Systemic infection;FunDO |
Disease | Cancer;FunDO |
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External Links |
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Links to Entrez Gene | 7474 |
Links to all GeneRIF Items | 7474 |
Links to iHOP | 7474 |
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Sequence Information |
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Nucleotide Sequence |
>7474 : length: 1143 atgaagaagtccattggaatattaagcccaggagttgctttggggatggctggaagtgca atgtcttccaagttcttcctagtggctttggccatatttttctccttcgcccaggttgta attgaagccaattcttggtggtcgctaggtatgaataaccctgttcagatgtcagaagta tatattataggagcacagcctctctgcagccaactggcaggactttctcaaggacagaag aaactgtgccacttgtatcaggaccacatgcagtacatcggagaaggcgcgaagacaggc atcaaagaatgccagtatcaattccgacatcgaaggtggaactgcagcactgtggataac acctctgtttttggcagggtgatgcagataggcagccgcgagacggccttcacatacgcg gtgagcgcagcaggggtggtgaacgccatgagccgggcgtgccgcgagggcgagctgtcc acctgcggctgcagccgcgccgcgcgccccaaggacctgccgcgggactggctctggggc ggctgcggcgacaacatcgactatggctaccgctttgccaaggagttcgtggacgcccgc gagcgggagcgcatccacgccaagggctcctacgagagtgctcgcatcctcatgaacctg cacaacaacgaggccggccgcaggacggtgtacaacctggctgatgtggcctgcaagtgc catggggtgtccggctcatgtagcctgaagacatgctggctgcagctggcagacttccgc aaggtgggtgatgccctgaaggagaagtacgacagcgcggcggccatgcggctcaacagc cggggcaagttggtacaggtcaacagccgcttcaactcgcccaccacacaagacctggtc tacatcgaccccagccctgactactgcgtgcgcaatgagagcaccggctcgctgggcacg cagggccgcctgtgcaacaagacgtcggagggcatggatggctgcgagctcatgtgctgc ggccgtggctacgaccagttcaagaccgtgcagacggagcgctgccactgcaagttccac tggtgctgctacgtcaagtgcaagaagtgcacggagatcgtggaccagtttgtgtgcaag tag |
Protein Sequence |
>7474 : length: 380 MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEANSWWSLGMNNPVQMSEV YIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDN TSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWG GCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKC HGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLV YIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFH WCCYVKCKKCTEIVDQFVCK |