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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7703 |
Name | PCGF2 |
Synonym | MEL-18|RNF110|ZNF144;polycomb group ring finger 2;PCGF2;polycomb group ring finger 2 |
Definition | DNA-binding protein Mel-18|polycomb group RING finger protein 2|ring finger protein 110|zinc finger protein 144 |
Position | 17q12 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
reviewed | BMI1 acts as an oncogene and Mel-18 functions as a tumor suppressor via downregulation of BMI1. |
reviewed | "The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance." |
reviewed | "Mel-18 and Bmi-1 may regulate the Akt pathway in breast cancer cells, and that Mel-18 functions as a tumor suppressor by repressing the expression of Bmi-1 and consequently down-regulating Akt activity." |
| More detail of all 3 literatures about PCGF2 | |
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External Links |
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Links to Entrez Gene | 7703 |
Links to all GeneRIF Items | 7703 |
Links to iHOP | 7703 |
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Sequence Information |
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Nucleotide Sequence |
>7703 : length: 1035 atgcatcggactacacggatcaaaatcacagagctgaacccccacctcatgtgtgccctc tgcggggggtacttcatcgacgccaccactatcgtggagtgcctgcattccttctgcaaa acctgcatcgtgcgctacctggagaccaacaaatactgccccatgtgtgacgtgcaggtc cataaaacccggccgctgctgagcatcaggtctgacaaaacacttcaagacattgtctac aaattggtccctgggctttttaaagatgagatgaaacggcggcgggatttctatgcagcg taccccctgacggaggtccccaacggctccaatgaggaccgcggcgaggtcttggagcag gagaagggggctctgagtgatgatgagattgtcagcctctccatcgaattctacgaaggt gccagggaccgggacgagaagaagggccccctggagaatggggatggggacaaagagaaa acaggggtgcgcttcctgcgatgcccagcagccatgaccgtcatgcatcttgccaagttt ctccgcaacaagatggatgtgcccagcaagtacaaggtggaggttctgtacgaggacgag ccactgaaggaatactacaccctcatggacatcgcctacatctacccctggcggcggaac gggcctctccccctcaagtaccgtgtccagccagcctgcaagcggctcaccctagccacg gtgcccaccccctccgagggcaccaacaccagcggggcgtccgagtgtgagtcagtcagc gacaaggctcccagccctgccaccctgccagccacctcctcctccctgcccagcccagcc accccatcccatggctctcccagttcccatgggcctccagccacccaccctacctccccc actcccccttcgacagccagtggggccaccacagctgccaacgggggtagcttgaactgc ctgcagacaccatcctccaccagcagggggcgcaagatgactgtcaacggcgctcccgtg ccccccttaacttga |
Protein Sequence |
>7703 : length: 344 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQ EKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMHLAKF LRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLAT VPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSP TPPSTASGATTAANGGSLNCLQTPSSTSRGRKMTVNGAPVPPLT |