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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 7799 |
Name | PRDM2 |
Synonym | HUMHOXY1|KMT8|MTB-ZF|RIZ|RIZ1|RIZ2;PR domain containing 2, with ZNF domain;PRDM2;PR domain containing 2, with ZNF domain |
Definition | GATA-3 binding protein G3B|GATA-3-binding protein G3B|MTE-binding protein|PR domain zinc finger protein 2|PR domain-containing protein 2|lysine N-methyltransferase 8|retinoblastoma protein-binding zinc finger protein|retinoblastoma protein-interacting zin |
Position | 1p36.21 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 8 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Anticancer activity of the PR domain of tumor suppressor RIZ1. |
reviewed | Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications. |
reviewed | DNA methylation of the RIZ1 tumor suppressor gene plays an important role in the tumorigenesis of cervical cancer. |
potential | RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression. |
reviewed | Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma. |
reviewed | "tumor suppressor RIZ1 (PRDM2) methylates histone H3 on lysine 9, and this activity is reduced by mutations in the PR domain found in human cancers." |
reviewed | "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily." |
reviewed | "Retinoblastoma protein-interacting zinc finger 1, a tumor suppressor, augments lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation." |
| More detail of all 8 literatures about PRDM2 | |
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External Links |
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Links to Entrez Gene | 7799 |
Links to all GeneRIF Items | 7799 |
Links to iHOP | 7799 |
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Sequence Information |
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Nucleotide Sequence |
>7799 : length: 4446 atgagagattctgcagaaggtcctaaagaagacgaagagaagccttcagcctcagcactt gagcagccggccaccctccaggaggtggccagtcaggaggtgcctccagaactagcaacc cctgcccctgcctgggagccacagccagaaccagacgagcgattagaagcggcagcttgt gaggtgaatgatttgggggaagaggaggaggaggaagaggaggaggatgaagaagaagaa gaagatgatgatgatgatgagttggaagacgagggggaagaagaagccagcatgccaaat gaaaattctgtgaaagagccagaaatacggtgtgatgagaagccagaagatttattagag gaaccaaaaacaacttcagaagaaactcttgaagactgctcagaggtaacacctgccatg caaatccccagaactaaagaagaggccaatggtgatgtatttgaaacgtttatgtttccg tgtcaacattgtgaaaggaagtttacaaccaaacaggggcttgagcgtcacatgcatatc catatatccaccgtcaatcatgctttcaaatgcaagtactgtgggaaagcctttggcaca cagattaaccggcggcgacatgagcggcgccatgaagcagggttaaagcggaaacccagc caaacactacagccgtcagaggatctggctgatggcaaagcatctggagaaaacgttgct tcaaaagatgattcgagtcctcccagtcttgggccagactgtctgatcatgaattcagag aaggcttcccaagacacaataaattcttctgtcgtagaagagaatggggaagttaaagaa cttcatccgtgcaaatattgtaaaaaggtttttggaactcatactaatatgagacggcat cagcgtagagttcacgaacgtcatctgattcccaaaggtgtacggcgaaaaggaggcctt gaagagccccagcctccagcagaacaggcccaggccacccagaacgtgtatgtaccaagc acagagccggaggaggaaggggaagcagatgatgtgtacatcatggacatttctagcaat atctctgaaaacttaaattactatattgatggtaaaattcaaactaataacaacactagt aactgtgatgtgattgagatggagtctgcttcggcagatttgtatggtataaattgtctg ctcactccagttacagtggaaattactcaaaatataaagaccacacaggtccctgtaaca gaagatcttcctaaagagcctttgggcagcacaaatagtgaggccaagaagcggagaact gcgagcccacctgcactgcccaaaattaaggccgaaacagactctgaccccatggtcccc tcttgctctttaagtcttcctcttagcatatcaacaacagaggcagtgtctttccacaaa gagaaaagtgtttatttgtcatcaaagctcaaacaacttcttcaaacccaagataaacta actcctgcagggatttcagcaactgaaatagctaaattaggtcctgtttgtgtgtctgct cctgcatcaatgttgcctgtgacctcaagtaggtttaagaggcggaccagctctcctccc agttctccacagcacagtcctgcccttcgagactttggaaagccaagtgatgggaaagca gcatggaccgatgccgggctgacttccaaaaaatccaaattagaaagtcacagcgactca ccagcatggagtttgtctgggagagatgagagagaaactgtgagccctccatgctttgat gaatataaaatgtctaaagagtggacagctagttctgcttttagcagtgtgtgcaaccag cagccactggatttatccagcggtgtcaaacagaaggctgagggtacaggcaagactcca gtccagtgggaatctgtcttagatctcagtgtgcataaaaagcattgtagtgactctgaa ggcaaggaattcaaagaaagtcattcagtgcagcctacgtgtagtgctgtaaagaaaagg aaaccaaccacctgcatgctgcagaaggttcttctcaatgaatataatggcatcgattta cctgtagaaaaccctgcagatgggaccaggagcccaagtccttgtaaatccctagaagct cagccagatcctgacctcggtccgggctctggtttccctgcccctactgttgagtccaca cctgatgtttgtccttcatcacctgccctgcagacaccctccctttcatccggtcagctg cctcctctcttgatccccacagatccctcttcccctccaccctgtcccccggtattaact gttgccactccgccccctcccctccttcctaccgtacctcttccagccccctcttccagt gcatctccacacccatgcccctctccactctcaaatgccaccgcacagtccccacttcca attctgtccccaacagtgtccccctctccctctcccattcctcccgtggagcccctgatg tctgccgcctcacccgggcctccaacactttcttcttcctcctcttcatcttcctcctcc tcttcgttttcttcttcatcttcctcctcttctccttctccacctcctctctccgcaata tcatctgttgtttcctctggtgataatctggaggcttctctccccatgatatctttcaaa caggaggaattagagaatgaaggtctgaaacccagggaagagccccagtctgctgctgaa caggatgttgttgttcaggaaacattcaacaaaaactttgtttgcaacgtctgtgaatca ccttttctttccattaaagatctaaccaaacatttatctattcatgctgaagaatggccc ttcaaatgtgaattttgtgtgcagctttttaaggataaaacggacttgtcagaacatcgc tttttgcttcatggagttgggaatatctttgtgtgttctgtttgtaaaaaagaatttgct tttttgtgcaatttgcagcagcaccagcgagatctccacccagataaggtgtgcacacat cacgagtttgaaagcgggactctgaggccccagaactttacagatcccagcaaggcccat gtagagcatatgcagagcttgccagaagatcctttagaaacttctaaagaagaagaggag ttaaatgattcctctgaagagctttacacgactataaaaataatggcttctggaataaag acaaaagatccagatgttcgattgggcctcaatcagcattacccaagctttaaaccacct ccatttcagtaccatcaccgtaaccccatggggattggtgtgacagccacaaatttcact acacacaatattccacagactttcactaccgccattcgctgcacaaagtgtggaaaaggt gtcgacaatatgccggagttgcacaaacatatcctggcttgtgcttctgcaagtgacaag aagaggtacacgcctaagaaaaacccagtaccattaaaacaaactgtgcaacccaaaaat ggcgtggtggttttagataactctgggaaaaatgccttccgacgaatgggacagcccaaa aggcttaactttagtgttgagctcagcaaaatgtcgtcgaataagctcaaattaaatgca ttgaagaaaaaaaatcagctagtacagaaagcaattcttcagaaaaacaaatctgcaaag cagaaggccgacttgaaaaatgcttgtgagtcatcctctcacatctgcccttactgtaat cgagagttcacttacattggaagcctgaataaacacgccgccttcagctgtcccaaaaaa cccctttctcctcccaaaaaaaaagtttctcattcatctaagaaaggtggacactcatca cctgcaagtagtgacaaaaacagtaacagcaaccaccgcagacggacagcggatgcggag attaaaatgcaaagcatgcagactccgttgggcaagaccagagcccgcagctcaggcccc acccaagtcccacttccctcctcatccttcaggtccaagcagaacgtcaagtttgcagct tcggtgaaatccaaaaaaccaagctcctcctctttaaggaactccagcccgataagaatg gccaaaataactcatgttgaggggaaaaaacctaaagctgtggccaagaatcattctgct cagctttccagcaaaacatcacggagcctgcacgtgagggtacagaaaagcaaagctgtt ttacaaagcaaatccaccttggcgagtaagaaaagaacagaccggttcaatataaaatct agagagcggagtggggggccagtcacccggagccttcagctggcagctgctgctgacttg agtgagaacaagagagaggacggcagcgccaagcaggagctgaaggacttcaggaacttc ctgtag |
Protein Sequence |
>7799 : length: 1481 MRDSAEGPKEDEEKPSASALEQPATLQEVASQEVPPELATPAPAWEPQPEPDERLEAAAC EVNDLGEEEEEEEEEDEEEEEDDDDDELEDEGEEEASMPNENSVKEPEIRCDEKPEDLLE EPKTTSEETLEDCSEVTPAMQIPRTKEEANGDVFETFMFPCQHCERKFTTKQGLERHMHI HISTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKPSQTLQPSEDLADGKASGENVA SKDDSSPPSLGPDCLIMNSEKASQDTINSSVVEENGEVKELHPCKYCKKVFGTHTNMRRH QRRVHERHLIPKGVRRKGGLEEPQPPAEQAQATQNVYVPSTEPEEEGEADDVYIMDISSN ISENLNYYIDGKIQTNNNTSNCDVIEMESASADLYGINCLLTPVTVEITQNIKTTQVPVT EDLPKEPLGSTNSEAKKRRTASPPALPKIKAETDSDPMVPSCSLSLPLSISTTEAVSFHK EKSVYLSSKLKQLLQTQDKLTPAGISATEIAKLGPVCVSAPASMLPVTSSRFKRRTSSPP SSPQHSPALRDFGKPSDGKAAWTDAGLTSKKSKLESHSDSPAWSLSGRDERETVSPPCFD EYKMSKEWTASSAFSSVCNQQPLDLSSGVKQKAEGTGKTPVQWESVLDLSVHKKHCSDSE GKEFKESHSVQPTCSAVKKRKPTTCMLQKVLLNEYNGIDLPVENPADGTRSPSPCKSLEA QPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPSSPPPCPPVLT VATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPPVEPLM SAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSGDNLEASLPMISFK QEELENEGLKPREEPQSAAEQDVVVQETFNKNFVCNVCESPFLSIKDLTKHLSIHAEEWP FKCEFCVQLFKDKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTH HEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLETSKEEEELNDSSEELYTTIKIMASGIK TKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKG VDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPK RLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKNACESSSHICPYCN REFTYIGSLNKHAAFSCPKKPLSPPKKKVSHSSKKGGHSSPASSDKNSNSNHRRRTADAE IKMQSMQTPLGKTRARSSGPTQVPLPSSSFRSKQNVKFAASVKSKKPSSSSLRNSSPIRM AKITHVEGKKPKAVAKNHSAQLSSKTSRSLHVRVQKSKAVLQSKSTLASKKRTDRFNIKS RERSGGPVTRSLQLAAAADLSENKREDGSAKQELKDFRNFL |