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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 7869 |
Name | SEMA3B |
Synonym | LUCA-1|SEMA5|SEMAA|SemA|semaV;sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B;SEMA3B;sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B |
Definition | sema A(V)|sema V|semaphorin A|semaphorin V|semaphorin-3B|semaphorin-V |
Position | 3p21.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 7 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG. |
reviewed | IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. |
potential | SEMA3B is a potential tumor suppressor that induces apoptosis in SEMA3B-inactivated tumor cells through the Np-1 receptor by inactivating the Akt signaling pathway. |
reviewed | The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment. |
reviewed | High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene. |
potential | Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. |
potential | The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 tumor suppressor Gene Consortium. |
| More detail of all 7 literatures about SEMA3B | |
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Pathways and Diseases |
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Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
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External Links |
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Links to Entrez Gene | 7869 |
Links to all GeneRIF Items | 7869 |
Links to iHOP | 7869 |
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Sequence Information |
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Nucleotide Sequence |
>7869 : length: 2247 atggggcgggccggggctgccgccgtgatcccgggcctggccctgctctgggcagtgggg ctggggagtgccgcccccagccccccacgccttcggctctccttccaagagctccaggcc tggcatggtctccagactttcagcctggagcgaacctgctgctaccaggccttgctggtg gatgaggagcgtggacgcctgtttgtgggtgccgagaaccatgtggcctccctcaacctg gacaacatcagcaagcgggccaagaagctggcctggccggcccctgtggaatggcgagag gagtgcaactgggcagggaaggacattggtactgagtgcatgaacttcgtgaagttgctg catgcctacaaccgcacccatttgctggcctgtggcacgggagccttccacccaacctgt gcctttgtggaagtgggccaccgggcagaggagcccgtcctccggctggacccaggaagg atagaggatggcaaggggaagagtccttatgaccccaggcatcgggctgcctccgtgctg gtgggggaggagctatactcaggggtggcagcagacctcatgggacgagactttaccatc tttcgcagcctagggcaacgtccaagtctccgaacagagccacacgactcccgctggctc aatgagcccaagtttgtcaaggtattttggatcccggagagcgagaacccagacgacgac aaaatctacttcttctttcgtgagacggcggtagaggcggcgccggcactgggacgcctg tccgtgtcccgcgttggccagatctgccggaacgacgtgggcggccagcgcagcctggtc aacaagtggacgacgttcctgaaggcgcggctggtgtgctcggtgcccggcgtcgagggc gacacccacttcgatcagctccaggatgtgtttctgttgtcctcgcgggaccaccggacc ccgctgctctatgccgtcttctccacgtccagcatcttccagggctctgcggtgtgcgtg tacagcatgaacgacgtgcgccgggccttcttgggaccctttgcacacaaggaggggccc atgcaccagtgggtgtcataccagggtcgcgtcccctacccgcggccaggcatgtgcccc agcaagacctttggcaccttcagttccaccaaggacttcccagacgatgtcatccagttt gcgcggaaccaccccctcatgtacaactctgtcctgcccactggggggcgccctcttttc ctacaagttggagccaattacaccttcactcaaattgccgcggaccgggttgcagccgct gacggacactatgacgtcctcttcattggcacagacgttggcacggtgctgaaggtgatc tcggtccccaagggcagtaggcccagcgcagaggggctgctcctggaggagctgcacgtg tttgaggactcggccgctgtcaccagcatgcaaatttcttccaagaggcaccagctgtac gtagcctcgcggagcgcggtggcccagatcgcgttgcaccgctgcgctgcccacggccgc gtctgcaccgaatgctgtctggcgcgtgacccctactgcgcctgggacggggtcgcgtgc acgcgcttccagcccagtgccaagaggcggttccggcggcaagacgtaaggaatggcgac cccagcacgttgtgctccggagactcgtctcgtcccgcgctgctggaacacaaggtgttc ggcgtggagggcagcagcgcctttctggagtgtgagccccgctcgctgcaggcgcgcgtg gagtggactttccagcgcgcaggggtgacagcccacacccaggtgctggcagaggagcgc accgagcgcaccgcccggggactactgctgcgcaggctgcggcgccgggactcgggcgtg tacttgtgcgccgccgtcgagcagggctttacgcaaccgctgcgtcgcctgtcgctgcac gtgttgagtgctacgcaggccgaacgactggcgcgggccgaggaggctgcgcccgccgcg ccgccgggccccaaactctggtaccgggactttctgcagctggtggagccgggcggaggt ggcagcgcgaactccctgcgcatgtgccgcccgcagcctgcgctgcagtcactgcccctg gagtcgcggagaaagggccgtaaccggaggacccacgcccctgagcctcgcgctgagcgg gggccgcgcagcgcaacgcactggtga |
Protein Sequence |
>7869 : length: 748 MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLV DEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLL HAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVL VGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDD KIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEG DTHFDQLQDVFLLSSRDHRTPLLYAVFSTSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGP MHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLF LQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHV FEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVAC TRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQARV EWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLH VLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLPL ESRRKGRNRRTHAPEPRAERGPRSATHW |