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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8100 |
Name | IFT88 |
Synonym | D13S1056E|DAF19|TG737|TTC10|hTg737;intraflagellar transport 88 homolog (Chlamydomonas);IFT88;intraflagellar transport 88 homolog (Chlamydomonas) |
Definition | TPR repeat protein 10|intraflagellar transport protein 88 homolog|polaris homolog|probe hTg737 (polycystic kidney disease, autosomal recessive)|recessive polycystic kidney disease protein Tg737 homolog|tetratricopeptide repeat domain 10|tetratricopeptide |
Position | 13q12.1 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
reviewed | The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. |
reviewed | The results indicate that loss of heterozygosity of the tumor suppressor gene Tg737 may play an important role in the carcinogenetic mechanism of liver cancer stem cells. |
potential | "Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas." |
| More detail of all 3 literatures about IFT88 | |
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Pathways and Diseases |
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Pathway | Hedgehog signaling events mediated by Gli proteins;PID Curated;200147 |
Disease | Schizophrenia, bipolar disorder and depression (combined);NHGRI |
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External Links |
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Links to Entrez Gene | 8100 |
Links to all GeneRIF Items | 8100 |
Links to iHOP | 8100 |
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Sequence Information |
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Nucleotide Sequence |
>8100 : length: 2475 atgatgcaaaatgtgcacctggctccagagacagatgaagatgatctttattccggctat aatgactacaatccaatctatgatatcgaggaattggagaatgatgcagcttttcagcaa gctgtgaggactagtcatggcagaagacctccaataactgctaaaatatcaagcacggca gttactagacctatagctactggatatgggtccaagacatctctggcatcatcaatagga agaccaatgacaggggctattcaggatggagttactagacccatgacagcagtgagagca gctggttttaccaaagcagctttgagaggctctgcatttgacccccttagtcagtcaagg ggccctgcttcccctttggaagccaagaaaaaagatagcccagaggaaaaaataaagcaa ttagagaaggaagtaaatgagttggtagaagaaagctgtattgccaatagttgtggagac ttaaaattggccttagaaaaggcaaaagatgcaggaagaaaagagagagtcctggtgaga cagcgagaacaagttacaactccagaaaatatcaatttggatttaacttactcagttctt ttcaatttggccagtcagtattcagttaatgaaatgtatgccgaagcacttaacacttat caagttatagtcaaaaataagatgtttagcaatgcaggaatattgaaaatgaatatggga aatatctatttaaagcaaagaaattattccaaagccattaaattctaccgaatggcatta gaccaagttccaagtgtcaataagcaaatgaggattaaaataatgcagaatattggagtt acatttattcaggctggtcagtattcagatgctattaattcatatgagcacataatgagc atggcaccaaatctgaaggcaggctacaacctaactatctgttattttgctattggagac cgagaaaaaatgaagaaggcattccaaaaattgattactgttccattagaaattgatgaa gataaatatatttcaccaagtgatgatcctcatactaacttagtaactgaagctataaaa aatgatcacctcaggcaaatggaacgtgaaaggaaagccatggcagaaaaatatattatg acatctgcaaaactcattgctcctgtaattgaaacatcttttgctgcaggttatgattgg tgcgtggaagtggtgaaagcttctcaatatgtagagctagccaatgatctggaaataaac aaagcagttacatacttgagacaaaaagactataaccaagctgtagagatcttaaaagtg ttggaaaaaaaggacagtagagtgaaaagtgcagctgcaaccaatctctcagccctgtat tatatgggaaaggattttgcacaagccagcagctatgcagatatagctgtgaactctgat agatataatccagcagctcttactaataaagggaatacagtttttgcaaatggtgattat gagaaggccgctgaattctataaagaggctctaagaaatgattcttcttgtactgaagca ctttataatattggccttacctatgagaaactaaatcggctagatgaggctttggactgt ttcctgaaacttcacgcaatcctacgaaacagtgccgaagttctttaccagatagcaaat atatatgaattaatggaaaatcccagtcaagctattgaatggctaatgcaggtggtcagt gttattccaaccgatcctcaagttttatctaagctaggagaattatatgatcgtgaagga gataaatctcaagcatttcaatattactatgagtcatataggtattttccttgtaatatt gaagtcattgagtggcttggagcctattacattgacacccaattttgggaaaaagctatt cagtactttgaaagagcttctcttatacagcctacacaagtgaaatggcagctgatggta gctagttgtttcagaagaagtggtaactaccaaaaagcattagatacttacaaagatact cacagaaaatttccagaaaatgtcgaatgtctgcgtttcttagttcgtctctgcacagat cttggattaaaagatgctcaagaatatgccagaaaactgaagaggttggaaaaaatgaaa gaaataagggaacagcgcataaagtcaggcagagatggcagtgggggctcccgtggcaaa agagaaggaagtgctagcggtgatagtggccagaactatagtgccagtagtaaaggtgaa cgactaagtgccagactcagagctttacctgggacaaatgaaccttatgaaagtagcagt aacaaagaaatagatgcctcctatgtggacccacttggccctcaaatagaacgaccaaaa actgcagccaagaaaaggatcgatgaggatgattttgctgatgaagaattaggagatgat ttgcttccagaataa |
Protein Sequence |
>8100 : length: 824 MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE |