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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 8313 |
Name | AXIN2 |
Synonym | AXIL;axin 2;AXIN2;axin 2 |
Definition | axin-2|axin-like protein|axis inhibition protein 2|conductin |
Position | 17q23-q24 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Accumulated evidence suggests that alterations due to mutations or genetic polymorphisms in the AXIN2 tumor suppressor gene, a component of the Wnt signaling pathway, contributes to carcinogenesis." |
potential | Both AXIN2 and TCF7L2 genes in the Wnt pathway possess mononucleotide repeats in their coding sequences and are considered as candidate tumor suppressor genes. |
reviewed | The combination of our findings and numerous genetic and functional studies showing that APC and AXIN2 perform crucial tumor suppressor functions suggest that further investigation of the contribution of AXIN2 and APC SNPs to breast cancer risk are needed. |
reviewed | "The pathway is negatively controlled by the tumor suppressor AXIN2 (Conductin), a scaffold protein of this signaling complex." |
| More detail of all 4 literatures about AXIN2 | |
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Pathways and Diseases |
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Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | Canonical Wnt signaling pathway;PID Curated;200064 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Disease | Oligodontia-colorectal cancer syndrome;OMIM |
Disease | Colorectal cancer;OMIM |
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External Links |
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Links to Entrez Gene | 8313 |
Links to all GeneRIF Items | 8313 |
Links to iHOP | 8313 |
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Sequence Information |
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Nucleotide Sequence |
>8313 : length: 2532 atgagtagcgctatgttggtgacttgcctcccggaccccagcagcagcttccgtgaggat gccccgcggcccccagtgccaggggaagaaggggagaccccaccgtgtcagccaggggtg ggcaagggccaggtcaccaaacccatgcctgtctcttccaacaccaggcggaacgaagat gggttgggggagccggaggggcgggcatctccggattcccctctgacccggtggaccaag tccttacactccttattgggcgatcaagacggtgcttacctgttccgaactttcctggag agggagaaatgcgtggataccttagacttctggtttgcctgcaatggattcaggcagatg aacctgaaggataccaaaactttacgagtagccaaagcgatctacaaaaggtacattgag aacaacagcattgtctccaagcagctgaagcctgccaccaagacctacataagagatggc atcaagaagcagcagattgattccatcatgtttgaccaggcgcagaccgagatccagtcg gtgatggaggaaaatgcctaccagatgtttttgacttctgatatatacctcgaatatgtg aggagtgggggagaaaacacagcttacatgagtaatgggggactcgggagcctaaaggtc gtgtgtggctatctccccaccttgaatgaagaagaggagtggacttgtgccgacttcaag tgcaaactttcgccaaccgtggttggcttgtccagcaaaactctgagggccacggcgagt gtgaggtccacggaaactgttgacagtggatacaggtccttcaagaggagcgatcctgtt aatccttatcacataggttctggctatgtctttgcaccagccaccagcgccaacgacagt gagatatccagtgatgcgctgacggatgattccatgtccatgacggacagcagtgtagat ggaattcctccttatcgtgtgggcagtaagaaacagctccagagagaaatgcatcgcagt gtgaaggccaatggccaagtgtctctacctcatttcccgagaacccaccgcctgcccaag gagatgacccccgtggaacccgccacctttgcagctgagctgatctcgaggctggaaaag ctgaagctggagttggagagccgccacagcctggaggagcgcctgcagcagatccgagag gatgaagagagagagggctccgagctcacactcaattcgcgggagggggcgcccacgcag caccccctctccctactgccctccggcagctacgaggaagacccgcagacgatactggac gatcacctgtccagggtcctcaagacccctggctgccagtctccaggcgtaggccgctat agcccccgctcccgctccccggaccaccaccaccaccaccattcgcagtaccactccctg ctcccgcccggtggcaagctgcctcccgcggccgcctcgccgggcgcctgccccctcctc gggggcaaaggctttgtgaccaagcagacgacgaagcatgtccaccaccactacatccac caccatgccgtccccaagaccaaggaggagatcgaggcggaggccacgcagcgggtgcac tgcttctgccctgggggcagcgagtattactgctactcgaaatgcaaaagccactccaag gctccggaaaccatgcccagcgagcagtttggcggcagcagaggcagtaccttgcccaaa cgcaatgggaaaggcacggagccgggcctggccctgcccgccagggaaggaggggccccc ggcggagctggggccctgcagcttccccgggaggaaggagacaggtcgcaggatgtctgg cagtggatgctggagagtgagcggcagagcaagcccaagccccatagtgcccaaagcaca aaaaaggcctaccccttggagtctgcccgctcgtctccaggcgaacgagccagccggcac catctgtgggggggcaacagcgggcacccccgcaccaccccccgtgcccacctgttcacc caggaccctgcgatgcctcccctgaccccacccaacacgctggctcagctggaggaggcc tgtcgcaggctagctgaggtgtcgaagcccccaaagcagcggtgctgtgtggccagtcag cagagggacaggaatcattcggccactgttcagacgggagccacacccttctccaatcca agcctggctccagaagatcacaaagagccaaagaaactggcaggtgtccacgcgctccag gccagtgagttggttgtcacttactttttctgtggggaagaaattccataccggaggatg ctgaaggctcagagcttgaccctgggccactttaaagagcagctcagcaaaaagggaaat tataggtattacttcaaaaaagcaagcgatgagtttgcctgtggagcggtgtttgaggag atctgggaggatgagacggtgctcccgatgtatgaaggccggattctgggcaaagtggag cggatcgattga |
Protein Sequence |
>8313 : length: 843 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNED GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE RID |