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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 841 |
Name | CASP8 |
Synonym | ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5;caspase 8, apoptosis-related cysteine peptidase;CASP8;caspase 8, apoptosis-related cysteine peptidase |
Definition | FADD-homologous ICE/CED-3-like protease|FADD-like ICE|ICE-like apoptotic protease 5|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|MORT1-associated ced-3 homolog|apoptotic cysteine protease|apoptotic protease Mch-5|caspase 8, apoptosis-related cystein |
Position | 2q33-q34 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | Association of caspase-8 and Src may help reconcile why a potential tumor suppressor such as caspase-8 is rarely absent in cancers. |
potential | CASP8 may function as a tumor suppressor gene in neuroendocrine lung tumors. |
| More detail of all 2 literatures about CASP8 | |
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Pathways and Diseases |
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Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Activation of Pro-Caspase 8;PID Reactome;501004 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | Caspase-mediated cleavage of cytoskeletal proteins;PID Reactome;500271 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | TNF signaling;PID Reactome;500256 |
Pathway | Death Receptor Signalling;PID Reactome;500254 |
Pathway | Caspase-8 is formed from procaspase-8;PID Reactome;500891 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | Activation, myristolyation of BID and translocation to mitochondria;PID Reactome;500259 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Pathway | tnfr1 signaling pathway;PID BioCarta;100015 |
Pathway | internal ribosome entry pathway;PID BioCarta;100120 |
Pathway | fas signaling pathway (cd95);PID BioCarta;100167 |
Pathway | Apoptotic execution phase;PID Reactome;500269 |
Pathway | caspase cascade in apoptosis;PID BioCarta;100218 |
Pathway | Huntington disease;PANTHER;P00029 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | TRAIL signaling;PID Reactome;500257 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | Viral myocarditis;KEGG PATHWAY;hsa05416 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha;PID Curated;200133 |
Pathway | induction of apoptosis through dr3 and dr4/5 death receptors;PID BioCarta;100189 |
Pathway | FasL/ CD95L signaling;PID Reactome;500255 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | ceramide signaling pathway;PID BioCarta;100206 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Disease | Autoimmune disease;FunDO |
Disease | Breast cancer, protection against;OMIM |
Disease | AIDS;FunDO |
Disease | Neurodegenerative disorder;FunDO |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Systemic scleroderma;FunDO |
Disease | Autoimmune lymphoproliferative syndrome, type IIB;OMIM |
Disease | Glioma;GAD |
Disease | breast cancer;GAD |
Disease | CANCER;GAD |
Disease | Lung cancer, protection against;OMIM |
Disease | Intracranial hypertension;FunDO |
Disease | breast cancer cervical cancer colorectal cancer esophageal cancer lung cancer stomach cancer;GAD |
Disease | Autoimmune lymphoproliferative syndromes;KEGG DISEASE;H00108 |
Disease | Anthracosis;GAD |
Disease | Cancer;FunDO |
Disease | Hepatocellular carcinoma, somatic;OMIM |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Immunologic deficiency syndrome;FunDO |
Disease | Diabetes mellitus;FunDO |
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External Links |
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Links to Entrez Gene | 841 |
Links to all GeneRIF Items | 841 |
Links to iHOP | 841 |
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Sequence Information |
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Nucleotide Sequence |
>841 : length: 1395 atggacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcc tccctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggat gccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtcc ttcctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaac actagaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcc tacagggtcatgctctatcagatttcagaagaagtgagcagatcagaattgaggtctttt aagtttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctg gatattttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctg aaaagagtctgtgcccaaatcaacaagagcctgctgaagataatcaacgactatgaagaa ttcagcaaaggggaggagttgtgtggggtaatgacaatctcggactctccaagagaacag gatagtgaatcacagactttggacaaagtttaccaaatgaaaagcaaacctcggggatac tgtctgatcatcaacaatcacaattttgcaaaagcacgggagaaagtgcccaaacttcac agcattagggacaggaatggaacacacttggatgcaggggctttgaccacgacctttgaa gagcttcattttgagatcaagccccacgatgactgcacagtagagcaaatctatgagatt ttgaaaatctaccaactcatggaccacagtaacatggactgcttcatctgctgtatcctc tcccatggagacaagggcatcatctatggcactgatggacaggaggcccccatctatgag ctgacatctcagttcactggtttgaagtgcccttcccttgctggaaaacccaaagtgttt tttattcaggcttgtcagggggataactaccagaaaggtatacctgttgagactgattca gaggagcaaccctatttagaaatggatttatcatcacctcaaacgagatatatcccggat gaggctgactttctgctggggatggccactgtgaataactgtgtttcctaccgaaaccct gcagagggaacctggtacatccagtcactttgccagagcctgagagagcgatgtcctcga ggcgatgatattctcaccatcctgactgaagtgaactatgaagtaagcaacaaggatgac aagaaaaacatggggaaacagatgcctcagcctactttcacactaagaaaaaaacttgtc ttcccttctgattga |
Protein Sequence |
>841 : length: 464 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD |