|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8434 |
Name | RECK |
Synonym | ST15;reversion-inducing-cysteine-rich protein with kazal motifs;RECK;reversion-inducing-cysteine-rich protein with kazal motifs |
Definition | membrane-anchored glycoprotein (metastasis and invasion)|reversion-inducing cysteine-rich protein with Kazal motifs|suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)|suppression of tumorigenicity 5 (reversion-in |
Position | 9p13.3 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,UniProt,Generif |
Literature support | Count: 10 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways. |
reviewed | A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. |
reviewed | The tumor suppressor RECK interferes with HER-2/Neu dimerization and attenuates its oncogenic signaling. |
reviewed | What we learn from transformation suppressor genes: lessons from RECK. |
reviewed | "Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs." |
reviewed | Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter. |
reviewed | [tumor suppressor RECK in prostate carcinoma. Decreased RECK expression as indicator of proteolytic imbalance]. |
reviewed | The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice. |
reviewed | Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. |
reviewed | Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts. |
| More detail of all 10 literatures about RECK | |
|
Pathways and Diseases |
|
Pathway | inhibition of matrix metalloproteinases;PID BioCarta;100045 |
|
External Links |
|
Links to Entrez Gene | 8434 |
Links to all GeneRIF Items | 8434 |
Links to iHOP | 8434 |
|
Sequence Information |
|
Nucleotide Sequence |
>8434 : length: 2916 atggcgaccgtccgggcctctctgcgaggtgcgctgctccttctgctggccgtggcgggg gtcgcggaggtggcagggggcctggctccgggcagtgcgggtgcattgtgttgtaatcat tcaaaggataaccaaatgtgccgtgatgtatgtgaacagattttctcctcaaaaagtgaa tcccgactaaaacatctgttgcagcgagccccagattattgcccagagacaatggttgaa atttggaattgtatgaattcatctttgccaggtgtgtttaagaagtctgatggctgggtt ggcttaggctgctgtgaactggctattgccttggagtgtcgacaggcatgcaagcaggca tcttcaaagaatgatatttccaaagtttgcagaaaagaatatgagaatgctcttttcagt tgcattagcagaaatgaaatgggctcggtttgttgcagttatgcaggtcatcacacaaac tgccgagaatactgtcaagccatttttcgaacagactcttctcctggtccatctcagata aaagcagtggaaaattattgcgcctctattagtccacaattaatacattgtgtgaacaat tatactcaatcttatccaatgaggaacccaacggatagtttatattgctgtgacagagct gaagaccatgcttgccaaaatgcctgcaagagaatcctgatgtccaagaaaacggaaatg gagattgttgatggtctcatcgagggttgtaagacccagcccttgcctcaagatcctctt tggcaatgttttcttgaaagctcacaatctgttcaccctggagtcactgtacaccctcct ccctctacaggcctcgatggggctaaattgcattgttgttctaaagcaaacacttcaaca tgtagggaactctgcactaaactttacagcatgagctggggcaatacacagagttggcaa gagtttgatcgcttttgtgaatataatccagtggaagtgtccatgttgacctgtttagcg gatgtccgggaaccttgccagttgggctgtagaaaccttacttactgtactaattttaac aacaggccaacagaacttttcaggagttgtaatgcacagtcagatcaaggagccatgaat gacatgaagttgtgggagaaaggaagcataaagatgccatttatcaatatacctgttctt gatattaaaaagtgccagccagagatgtggaaagcaatagcttgttcactgcagattaaa ccttgtcatagtaaatctcggggaagtattatttgcaaatcagattgtgtggagattctt aaaaaatgtggagaccagaacaaattccctgaagaccacacagctgaaagtatttgtgag cttctgtcacctacagatgatctgaagaattgtatacctttggatacatacctcaggcca agtactttaggtaacattgtagaagaagtgactcatccctgtaacccaaatccttgccct gccaatgagctctgtgaagtaaaccgaaaaggatgtccatctggagatccctgtcttcca tacttttgtgttcaaggttgcaaactgggagaagcttctgatttcattgtccgtcaaggg acactaatccaggtgccatcatctgcaggggaagttggttgttataaaatctgttcatgt ggacaaagtggactcttagaaaactgtatggaaatgcactgtatagacctccagaagtct tgtattgttggaggaaaaagaaaaagtcatggaacatcctttagtattgactgcaatgtc tgttcttgttttgctggcaatttggtgtgctctacccgcctttgcctcagtgagcacagt tcagaagatgaccgtcgtaccttcacaggtctgccctgtaactgtgcagatcagtttgtc cctgtatgtgggcagaatgggcgcacttaccccagtgcctgcattgctcgctgtgtgggc ctccaagaccatcagtttgagtttggatcatgcatgtcaaaggatccatgtaatcctaat ccctgccaaaaaaaccaaaggtgcatacccaaaccacaggtctgcctgacgacttttgat aaatttggatgtagccagtatgagtgtgtaccaagacagctcgcgtgtgaccaggtccaa gatcctgtttgtgacacagaccacatggagcacaacaatctctgcactttataccaaaga ggaaaaagcctctcttacaaaggtccctgccagcccttttgcagagcaaccgagcccgta tgtgggcacaatggtgagacctacagcagtgtgtgtgctgcctactcggatcgcgtggca gtcgattactatggggactgccaggccgtcggagtcctctcagagcacagctccgtcgcc gagtgtgcttctgtcaagtgtccttcgctcttggcagctggatgcaaacccatcatccca ccgggtgcttgttgcccattatgtgctgggatgttaagagttttatttgacaaagaaaaa ctggatactattgctaaggtaacaaataaaaagccaataacagttctggaaatacttcag aaaatccgcatgcacgtgtctgtcccacagtgtgatgtgtttggatacttcagcattgaa tcagaaattgtgatcctgatcattcccgtcgatcactatccaaaagctctgcagattgaa gcctgcaataaagaagcagagaagattgagtcccttatcaactctgacagcccgactttg gcgtcccatgtccctctctctgccctcatcatttcccaggtacaggtctccagcagtgtg ccatcggccggtgtcagggccaggccttcttgccactccctcctccttcccctcagcttg ggccttgccttgcacttgctctggacatataactga |
Protein Sequence |
>8434 : length: 971 MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSE SRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQA SSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQI KAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEM EIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTST CRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVSMLTCLADVREPCQLGCRNLTYCTNFN NRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQPEMWKAIACSLQIK PCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNCIPLDTYLRP STLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQG TLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNV CSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVG LQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQ DPVCDTDHMEHNNLCTLYQRGKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVA VDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEK LDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIE ACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPSCHSLLLPLSL GLALHLLWTYN |