|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8454 |
Name | CUL1 |
Synonym | -;cullin 1;CUL1;cullin 1 |
Definition | CUL-1|cullin-1 |
Position | 7q36.1 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 1 PubMed records as below. |
|
Evidence Status |
Description |
potential | CUL1 may function as a tumor suppressor by regulating PLK4 protein levels and thereby restraining excessive daughter centriole formation at maternal centrioles. |
| More detail of all 1 literatures about CUL1 | |
|
Pathways and Diseases |
|
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | Degradation of beta-catenin by the destruction complex;PID Reactome;500310 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | Parkinson disease;PANTHER;P00049 |
Pathway | Canonical Wnt signaling pathway;PID Curated;200064 |
Pathway | e2f1 destruction pathway;PID BioCarta;100034 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | SCF-beta-TrCP mediated degradation of Emi1;PID Reactome;500393 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Signaling by Wnt;Reactome;REACT:11045 |
Pathway | Interleukin-1 signaling;PID Reactome;500490 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | cyclin e destruction pathway;PID BioCarta;100166 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Circadian rhythm - mammal;KEGG PATHWAY;hsa04710 |
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Pathway | regulation of p27 phosphorylation during cell cycle progression;PID BioCarta;100087 |
|
External Links |
|
Links to Entrez Gene | 8454 |
Links to all GeneRIF Items | 8454 |
Links to iHOP | 8454 |
|
Sequence Information |
|
Nucleotide Sequence |
>8454 : length: 2331 atgtcgtcaacccggagccagaacccccacggcctgaagcagattggcctggaccagatc tgggacgacctcagagccggcatccagcaggtgtacacacggcagagcatggccaagtcc agatatatggagctctacactcatgtttataactactgtactagtgttcaccagtcaaac caagcacgaggagctggagttcctccttctaagtcgaaaaaggggcagacacctggagga gctcagtttgttggcctggaattatataaacgacttaaggaatttttgaagaattacttg acaaatcttcttaaggatggagaagatttgatggatgagagtgtactgaaattctacact caacaatgggaagattatcgattttcaagcaaagtgctgaatggaatttgtgcctacctc aatagacattgggttcgccgtgaatgtgacgaaggacgaaaaggaatatatgaaatctat tcgcttgcattggtgacttggagagactgtctgttcaggccactgaataaacaggtaaca aatgctgttttaaagctgattgaaaaggaaaggaatggtgaaaccatcaatacaagattg attagtggagttgtacagtcttacgtggaattggggctgaatgaagatgatgcatttgca aagggccctacgttaacagtgtataaagaatcctttgaatctcaatttttggctgacaca gagagattttataccagagagagtactgaattcttgcagcagaacccagttactgaatat atgaaaaaggcagaggctcgtctgcttgaggaacaacgaagagttcaggtttaccttcat gaaagcacacaagatgaattagcaaggaaatgtgaacaagtcctcattgaaaaacacttg gaaattttccacacagaatttcagaatttattggatgctgacaaaaatgaagatttggga cgcatgtataatcttgtatctagaatccaggatggcctaggagaattgaaaaaactgttg gagacacacattcataatcagggtcttgcagccattgaaaagtgtggagaagctgcttta aatgaccccaaaatgtatgtacagacagtgcttgatgttcataaaaaatacaatgccctg gtaatgtctgcattcaacaatgacgctggctttgtggctgctcttgataaggcttgtggt cgcttcataaacaacaacgcggttaccaagatggcccaatcatccagtaaatcccctgag ttgctggctcgatactgtgactccttgttgaagaaaagttccaagaacccagaggaggca gaactagaagacacactcaatcaagtgatggttgtcttcaagtacatagaagacaaagac gtatttcagaagttctatgcgaagatgctcgccaagaggctcgtccaccagaacagtgca agtgacgatgccgaagccagcatgatctccaagttaaagcaagcttgcgggttcgagtac acctctaaacttcagcgcatgtttcaagacattggcgtgagcaaagatctgaacgagcaa ttcaaaaagcacttgacaaactcagaacccctagacttggatttcagcattcaagtgctg agctccgggtcctggcccttccagcagtcttgtacatttgccttgccgtcagagttggaa cgtagttatcagcgattcacagctttctacgccagccgccacagtggccgaaaattgacg tggttatatcagttgtctaaaggagaattggtaactaactgcttcaaaaacagatatact ttgcaggcgtcgacattccagatggctatcctgcttcagtacaacacggaagatgcctac actgtgcagcagctgaccgacagcactcaaattaaaatggacattttggcgcaagtttta cagattttattaaagtcgaagctattggtcttggaagatgaaaatgcaaatgttgatgag gtggaattgaagccagataccttaataaaattatatcttggttataaaaataagaaatta agggttaacatcaatgtgccaatgaaaaccgaacagaagcaggaacaagaaaccacacac aaaaacatcgaggaagaccgcaaactactgattcaggcggccatcgtgagaatcatgaag atgaggaaggttctgaaacaccagcagttacttggcgaggtcctcactcagctgtcctcc aggttcaaacctcgagtccctgtgatcaagaaatgcattgacattctaattgagaaagaa tatttggagcgagtggatggtgaaaaggacacctacagttacttggcttaa |
Protein Sequence |
>8454 : length: 776 MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSN QARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYT QQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVT NAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADT ERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAAL NDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPE LLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA SDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVL SSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYT LQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDE VELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMK MRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA |