|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8633 |
Name | UNC5C |
Synonym | UNC5H3;unc-5 homolog C (C. elegans);UNC5C;unc-5 homolog C (C. elegans) |
Definition | netrin receptor UNC5C|protein unc-5 homolog 3|protein unc-5 homolog C|unc-5 homolog 3|unc5 (C.elegans homolog) c |
Position | 4q21-q23 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
|
Evidence Status |
Description |
potential | UNC5C might act as a tumor suppressor and UNC5C methylation might present a malignant potential in colorectal cancer. |
reviewed | may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis. |
| More detail of all 2 literatures about UNC5C | |
|
Pathways and Diseases |
|
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Axon guidance mediated by netrin;PANTHER;P00009 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
|
External Links |
|
Links to Entrez Gene | 8633 |
Links to all GeneRIF Items | 8633 |
Links to iHOP | 8633 |
|
Sequence Information |
|
Nucleotide Sequence |
>8633 : length: 2796 atgaggaaaggtctgcgggcgacagcggcccgctgcggactgggactgggatacttgctg caaatgctcgtgctacctgccctggccctgctcagcgccagcggcactggctccgccgcc caagatgatgacttttttcatgaactcccagaaacttttccttctgatccacctgagcct ctgccacatttccttattgagcctgaagaagcttatattgtgaagaataagcctgtgaac ctgtactgtaaagcaagccctgccacccagatctatttcaagtgtaatagtgaatgggtt catcagaaggaccacatagtagatgaaagagtagatgaaacttccggtctcattgtccgg gaagtgagcattgagatttcgcgccagcaagtggaagaactctttggacctgaagattac tggtgccagtgtgtggcctggagctccgcgggtaccacaaagagccggaaggcgtatgtg cgcattgcatatctacggaagacatttgagcaggaacccctaggaaaggaagtgtctttg gaacaggaagtcttactccagtgtcgaccacctgaagggatcccagtggctgaggtggaa tggttgaaaaatgaagacataattgatcccgttgaagatcggaatttttatattactatt gatcacaacctcatcataaagcaggcccgactctctgatactgcaaattacacctgtgtt gccaaaaacattgttgccaagaggaaaagtacaactgccactgtcatagtctatgtcaac ggtggctggtccacctggacggagtggtctgtgtgtaacagccgctgtggacgagggtat cagaaacgtacaaggacttgtaccaacccggcaccactcaatgggggtgccttctgtgaa gggcagagtgtgcagaaaatagcctgtactacgttatgcccagtggatggcaggtggacg ccatggagcaagtggtctacttgtggaactgagtgcacccactggcgcaggagggagtgc acggcgccagcccccaagaatggaggcaaggactgcgacggcctcgtcttgcaatccaag aactgcactgatgggctttgcatgcagactgctcctgattcagatgatgttgctctctat gttgggattgtgatagcagtgatcgtttgcctggcgatctctgtagttgtggccttgttt gtgtatcggaagaatcatcgtgactttgagtcagatattattgactcttcggcactcaat gggggctttcagcctgtgaacatcaaggcagcaagacaagatctgctggctgtaccccca gacctcacgtcagctgcagccatgtacagaggacctgtctatgccctgcatgacgtctca gacaaaatcccaatgaccaactctccaattctggatccactgcccaacctgaaaatcaaa gtgtacaacacctcaggtgctgtcaccccccaagatgacctctctgagtttacgtccaag ctgtcccctcagatgacccagtcgttgttggagaatgaagccctcagcctgaagaaccag agtctagcaaggcagactgatccatcctgtaccgcatttggcagcttcaactcgctggga ggtcaccttattgttcccaattcaggagtcagcttgctgattcccgctggggccattccc caagggagagtctacgaaatgtatgtgactgtacacaggaaagaaactatgaggccaccc atggatgactctcagacacttttgacccctgtggtgagctgtgggcccccaggagctctg ctcacccgcccagtcgtcctcactatgcatcactgcgcagaccccaataccgaggactgg aaaatactgctcaagaaccaggcagcacagggacagtgggaggatgtggtggtggtcggg gaggaaaacttcaccaccccctgctacattcagctggatgcagaggcctgccacatcctc acagagaacctcagcacctacgccctggtaggacattccaccaccaaagcggctgcgaag cgcctcaagctggccatctttgggcccctgtgctgctcctcgctggagtacagcatccga gtctactgtctggatgacacccaggatgccctgaaggaaattttacatcttgagagacag atgggaggacagctcctagaagaacctaaggctcttcattttaaaggcagcacccacaac ctgcgcctgtcaattcacgatatcgcccattccctctggaagagcaaattgctggctaaa tatcaggaaattccattttaccatgtttggagtggatctcaaagaaacctgcactgcacc ttcactctggaaagatttagcctgaacacagtggagctggtttgcaaactctgtgtgcgg caggtggaaggagaagggcagatcttccagctcaactgcaccgtgtcagaggaacctact ggcatcgatttgccgctgctggatcctgcgaacaccatcaccacggtcacggggcccagt gctttcagcatccctctccctatccggcagaagctctgtagcagcctggatgccccccag acgagaggccatgactggaggatgctggcccataagctgaacctggacaggtacttgaat tactttgccaccaaatccagcccaactggcgtaatcctggatctttgggaagcacagaac ttcccagatggaaacctgagcatgctggcagctgtcttggaagaaatgggaagacatgaa acggtggtgtccttagcagcagaagggcagtattaa |
Protein Sequence |
>8633 : length: 931 MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEP LPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVR EVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSL EQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCV AKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCE GQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSK NCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALN GGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIK VYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLG GHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGAL LTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHIL TENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQ MGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCT FTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPS AFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQN FPDGNLSMLAAVLEEMGRHETVVSLAAEGQY |