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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 8797 |
Name | TNFRSF10A |
Synonym | APO2|CD261|DR4|TRAILR-1|TRAILR1;tumor necrosis factor receptor superfamily, member 10a;TNFRSF10A;tumor necrosis factor receptor superfamily, member 10a |
Definition | TNF-related apoptosis inducing ligand receptor 1|TNF-related apoptosis-inducing ligand receptor 1|TRAIL receptor 1|TRAIL-R1|cytotoxic TRAIL receptor|death receptor 4|tumor necrosis factor receptor superfamily member 10A|tumor necrosis factor receptor supe |
Position | 8p21 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | TRAIL-R1 and TRAIL-R2 act as dosage-dependent tumor suppressor genes whose monoallelic deletion can impair TRAIL-induced apoptosis in B-cell lymphoma. |
| More detail of all 1 literatures about TNFRSF10A | |
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Pathways and Diseases |
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Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Disease | CANCER;GAD |
Disease | Emphysema;FunDO |
Disease | Pancreatitis;FunDO |
Disease | breast cancer;GAD |
Disease | leukemia, chronic lymphocytic;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Adenovirus infection;FunDO |
Disease | Asthma;FunDO |
Disease | Cancer;FunDO |
Disease | chronic lymphocytic leukaemia;GAD |
Disease | Leukoencephalopathy;FunDO |
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External Links |
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Links to Entrez Gene | 8797 |
Links to all GeneRIF Items | 8797 |
Links to iHOP | 8797 |
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Sequence Information |
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Nucleotide Sequence |
>8797 : length: 1407 atggcgccaccaccagctagagtacatctaggtgcgttcctggcagtgactccgaatccc gggagcgcagcgagtgggacagaggcagccgcggccacacccagcaaagtgtggggctct tccgcggggaggattgaaccacgaggcgggggccgaggagcgctccctacctccatggga cagcacggacccagtgcccgggcccgggcagggcgcgccccaggacccaggccggcgcgg gaagccagccctcggctccgggtccacaagaccttcaagtttgtcgtcgtcggggtcctg ctgcaggtcgtacctagctcagctgcaaccatcaaacttcatgatcaatcaattggcaca cagcaatgggaacatagccctttgggagagttgtgtccaccaggatctcatagatcagaa catcctggagcctgtaaccggtgcacagagggtgtgggttacaccaatgcttccaacaat ttgtttgcttgcctcccatgtacagcttgtaaatcagatgaagaagagagaagtccctgc accacgaccaggaacacagcatgtcagtgcaaaccaggaactttccggaatgacaattct gctgagatgtgccggaagtgcagcagagggtgccccagagggatggtcaaggtcaaggat tgtacgccctggagtgacatcgagtgtgtccacaaagaatcaggcaatggacataatata tgggtgattttggttgtgactttggttgttccgttgctgttggtggctgtgctgattgtc tgttgttgcatcggctcaggttgtggaggggaccccaagtgcatggacagggtgtgtttc tggcgcttgggtctcctacgagggcctggggctgaggacaatgctcacaacgagattctg agcaacgcagactcgctgtccactttcgtctctgagcagcaaatggaaagccaggagccg gcagatttgacaggtgtcactgtacagtccccaggggaggcacagtgtctgctgggaccg gcagaagctgaagggtctcagaggaggaggctgctggttccagcaaatggtgctgacccc actgagactctgatgctgttctttgacaagtttgcaaacatcgtgccctttgactcctgg gaccagctcatgaggcagctggacctcacgaaaaatgagatcgatgtggtcagagctggt acagcaggcccaggggatgccttgtatgcaatgctgatgaaatgggtcaacaaaactgga cggaacgcctcgatccacaccctgctggatgccttggagaggatggaagagagacatgca agagagaagattcaggacctcttggtggactctggaaagttcatctacttagaagatggc acaggctctgccgtgtccttggagtga |
Protein Sequence |
>8797 : length: 468 MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMG QHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGT QQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPC TTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNI WVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEIL SNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADP TETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTG RNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE |