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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8930 |
Name | MBD4 |
Synonym | MED1;methyl-CpG binding domain protein 4;MBD4;methyl-CpG binding domain protein 4 |
Definition | 3,N(4)-ethenocytosine glycosylase|G/5-fluorouracil mismatch glycosylase with biphasic kinetics|G/T mismatch glycosylase|G/U mismatch glycosylase|methyl-CpG-binding domain protein 4|methyl-CpG-binding endonuclease 1|methyl-CpG-binding protein MBD4|mismatch |
Position | 3q21.3 |
Gene Type | protein-coding |
Source | Count: 1; Pubmed_search |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Finally, we have analyzed mice mutant for Mbd4 and show that this gene functions in vivo as a tumor suppressor." |
| More detail of all 1 literatures about MBD4 | |
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Pathways and Diseases |
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Pathway | Base excision repair;KEGG PATHWAY;hsa03410 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | Depyrimidination;PID Reactome;500031 |
Pathway | Cleavage of the damaged pyrimidine;PID Reactome;501015 |
Pathway | Recognition and association of DNA glycosylase with site containing an affected pyrimidine;PID Reactome;500926 |
Pathway | Displacement of DNA glycosylase by APE1;PID Reactome;501000 |
Disease | lung cancer;GAD |
Disease | CANCER;GAD |
Disease | Cancer;FunDO |
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External Links |
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Links to Entrez Gene | 8930 |
Links to all GeneRIF Items | 8930 |
Links to iHOP | 8930 |
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Sequence Information |
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Nucleotide Sequence |
>8930 : length: 1743 atgggcacgactgggctggagagtctgagtctgggggaccgcggagctgcccccaccgtc acctctagtgagcgcctagtcccagacccgccgaatgacctccgcaaagaagatgttgct atggaattggaaagagtgggagaagatgaggaacaaatgatgataaaaagaagcagtgaa tgtaatcccttgctacaagaacccatcgcttctgctcagtttggtgctactgcaggaaca gaatgccgtaagtctgtcccatgtggatgggaaagagttgtgaagcaaaggttatttggg aagacagcaggaagatttgatgtgtactttatcagcccacaaggactgaagttcagatcc aaaagttcacttgctaattatcttcacaaaaatggagagacttctcttaagccagaagat tttgattttactgtactttctaaaaggggtatcaagtcaagatataaagactgcagcatg gcagccctgacatcccatctacaaaaccaaagtaacaattcaaactggaacctcaggacc cgaagcaagtgcaaaaaggatgtgtttatgccgccaagtagtagttcagagttgcaggag agcagaggactctctaactttacttccactcatttgcttttgaaagaagatgagggtgtt gatgatgttaacttcagaaaggttagaaagcccaaaggaaaggtgactattttgaaagga atcccaattaagaaaactaaaaaaggatgtaggaagagctgttcaggttttgttcaaagt gatagcaaaagagaatctgtgtgtaataaagcagatgctgaaagtgaacctgttgcacaa aaaagtcagcttgatagaactgtctgcatttctgatgctggagcatgtggtgagaccctc agtgtgaccagtgaagaaaacagccttgtaaaaaaaaaagaaagatcattgagttcagga tcaaatttttgttctgaacaaaaaacttctggcatcataaacaaattttgttcagccaaa gactcagaacacaacgagaagtatgaggatacctttttagaatctgaagaaatcggaaca aaagtagaagttgtggaaaggaaagaacatttgcatactgacattttaaaacgtggctct gaaatggacaacaactgctcaccaaccaggaaagacttcactggtgagaaaatatttcaa gaagataccatcccacgaacacagatagaaagaaggaaaacaagcctgtatttttccagc aaatataacaaagaagctcttagccccccacgacgtaaagcctttaagaaatggacacct cctcggtcaccttttaatctcgttcaagaaacactttttcatgatccatggaagcttctc atcgctactatatttctcaatcggacctcaggcaaaatggcaatacctgtgctttggaag tttctggagaagtatccttcagctgaggtagcaagaaccgcagactggagagatgtgtca gaacttcttaaacctcttggtctctacgatcttcgggcaaaaaccattgtcaagttctca gatgaatacctgacaaagcagtggaagtatccaattgagcttcatgggattggtaaatat ggcaacgactcttaccgaattttttgtgtcaatgagtggaagcaggtgcaccctgaagac cacaaattaaataaatatcatgactggctttgggaaaatcatgaaaaattaagtctatct taa |
Protein Sequence |
>8930 : length: 580 MGTTGLESLSLGDRGAAPTVTSSERLVPDPPNDLRKEDVAMELERVGEDEEQMMIKRSSE CNPLLQEPIASAQFGATAGTECRKSVPCGWERVVKQRLFGKTAGRFDVYFISPQGLKFRS KSSLANYLHKNGETSLKPEDFDFTVLSKRGIKSRYKDCSMAALTSHLQNQSNNSNWNLRT RSKCKKDVFMPPSSSSELQESRGLSNFTSTHLLLKEDEGVDDVNFRKVRKPKGKVTILKG IPIKKTKKGCRKSCSGFVQSDSKRESVCNKADAESEPVAQKSQLDRTVCISDAGACGETL SVTSEENSLVKKKERSLSSGSNFCSEQKTSGIINKFCSAKDSEHNEKYEDTFLESEEIGT KVEVVERKEHLHTDILKRGSEMDNNCSPTRKDFTGEKIFQEDTIPRTQIERRKTSLYFSS KYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWK FLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKY GNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS |