|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 9113 |
Name | LATS1 |
Synonym | WARTS|wts;LATS, large tumor suppressor, homolog 1 (Drosophila);LATS1;LATS, large tumor suppressor, homolog 1 (Drosophila) |
Definition | LATS (large tumor suppressor, Drosophila) homolog 1|WARTS protein kinase|h-warts|large tumor suppressor homolog 1|serine/threonine-protein kinase LATS1 |
Position | 6q25.1 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 14 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]. |
reviewed | KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif. |
reviewed | tumor suppressor LATS1 is a negative regulator of oncogene YAP. |
reviewed | The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death. |
reviewed | The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |
reviewed | tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. |
reviewed | "Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor." |
reviewed | Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. |
reviewed | WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. |
reviewed | "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor." |
| More detail of all 14 literatures about LATS1 | |
|
External Links |
|
Links to Entrez Gene | 9113 |
Links to all GeneRIF Items | 9113 |
Links to iHOP | 9113 |
|
Sequence Information |
|
Nucleotide Sequence |
>9113 : length: 3393 atgaagaggagtgaaaagccagaaggatatagacaaatgaggcctaagacctttcctgcc agtaactatactgtcagtagccggcaaatgttacaagaaattcgggaatcccttaggaat ttatctaaaccatctgatgctgctaaggctgagcataacatgagtaaaatgtcaaccgaa gatcctcgacaagtcagaaatccacccaaatttgggacgcatcataaagccttgcaggaa attcgaaactctctgcttccatttgcaaatgaaacaaattcttctcggagtacttcagaa gttaatccacaaatgcttcaagacttgcaagctgctggatttgatgaggatatggttata caagctcttcagaaaactaacaacagaagtatagaagcagcaattgaattcattagtaaa atgagttaccaagatcctcgacgagagcagatggctgcagcagctgccagacctattaat gccagcatgaaaccagggaatgtgcagcaatcagttaaccgcaaacagagctggaaaggt tctaaagaatccttagttcctcagaggcatggcccgccactaggagaaagtgtggcctat cattctgagagtcccaactcacagacagatgtaggaagacctttgtctggatctggtata tcagcatttgttcaagctcaccctagcaacggacagagagtgaaccccccaccaccacct caagtaaggagtgttactcctccaccacctccaagaggccagactccccctccaagaggt acaactccacctcccccttcatgggaaccaaactctcaaacaaagcgctattctggaaac atggaatacgtaatctcccgaatctctcctgtcccacctggggcatggcaagagggctat cctccaccacctctcaacacttcccccatgaatcctcctaatcaaggacagagaggcatt agttctgttcctgttggcagacaaccaatcatcatgcagagttctagcaaatttaacttt ccatcagggagacctggaatgcagaatggtactggacaaactgatttcatgatacaccaa aatgttgtccctgctggcactgtgaatcggcagccaccacctccatatcctctgacagca gctaatggacaaagcccttctgctttacaaacagggggatctgctgctccttcgtcatat acaaatggaagtattcctcagtctatgatggtgccaaacagaaatagtcataacatggaa ctatataacattagtgtacctggactgcaaacaaattggcctcagtcatcttctgctcca gcccagtcatccccgagcagtgggcatgaaatccctacatggcaacctaacataccagtg aggtcaaattcttttaataacccattaggaaatagagcaagtcactctgctaattctcag ccttctgctacaacagtcactgcaattacaccagctcctattcaacagcctgtgaaaagt atgcgtgtattaaaaccagagctacagactgctttagcacctacacacccttcttggata ccacagccaattcaaactgttcaacccagtccttttcctgagggaaccgcttcaaatgtg actgtgatgccacctgttgctgaagctccaaactatcaaggaccaccaccaccctaccca aaacatctgctgcaccaaaacccatctgttcctccatacgagtcaatcagtaagcctagc aaagaggatcagccaagcttgcccaaggaagatgagagtgaaaagagttatgaaaatgtt gatagtggggataaagaaaagaaacagattacaacttcacctattactgttaggaaaaac aagaaagatgaagagcgaagggaatctcgtattcaaagttattctcctcaagcatttaaa ttctttatggagcaacatgtagaaaatgtactcaaatctcatcagcagcgtctacatcgt aaaaaacaattagagaatgaaatgatgcgggttggattatctcaagatgcccaggatcaa atgagaaagatgctttgccaaaaagaatctaattacatccgtcttaaaagggctaaaatg gacaagtctatgtttgtgaagataaagacactaggaataggagcatttggtgaagtctgt ctagcaagaaaagtagatactaaggctttgtatgcaacaaaaactcttcgaaagaaagat gttcttcttcgaaatcaagtcgctcatgttaaggctgagagagatatcctggctgaagct gacaatgaatgggtagttcgtctatattattcattccaagataaggacaatttatacttt gtaatggactacattcctgggggtgatatgatgagcctattaattagaatgggcatcttt ccagaaagtctggcacgattctacatagcagaacttacctgtgcagttgaaagtgttcat aaaatgggttttattcatagagatattaaacctgataatattttgattgatcgtgatggt catattaaattgactgactttggcctctgcactggcttcagatggacacacgattctaag tactatcagagtggtgaccatccacggcaagatagcatggatttcagtaatgaatggggg gatccctcaagctgtcgatgtggagacagactgaagccattagagcggagagctgcacgc cagcaccagcgatgtctagcacattctttggttgggactcccaattatattgcacctgaa gtgttgctacgaacaggatacacacagttgtgtgattggtggagtgttggtgttattctt tttgaaatgttggtgggacaacctcctttcttggcacaaacaccattagaaacacaaatg aaggttatcaactggcaaacatctcttcacattccaccacaagctaaactcagtcctgaa gcttctgatcttattattaaactttgccgaggacccgaagatcgcttaggcaagaatggt gctgatgaaataaaagctcatccattttttaaaacaattgacttctccagtgacctgaga cagcagtctgcttcatacattcctaaaatcacacacccaacagatacatcaaattttgat cctgttgatcctgataaattatggagtgatgataacgaggaagaaaatgtaaatgacact ctcaatggatggtataaaaatggaaagcatcctgaacatgcattctatgaatttaccttc cgaaggttttttgatgacaatggctacccatataattatccgaagcctattgaatatgaa tacattaattcacaaggctcagagcagcagtcggatgaagatgatcaaaacacaggctca gagattaaaaatcgcgatctagtatatgtttaa |
Protein Sequence |
>9113 : length: 1130 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTE DPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVI QALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKG SKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPP QVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGY PPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQ NVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNME LYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNV TVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENV DSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHR KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAAR QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTF RRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV |