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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 9353 |
Name | SLIT2 |
Synonym | SLIL3|Slit-2;slit homolog 2 (Drosophila);SLIT2;slit homolog 2 (Drosophila) |
Definition | slit homolog 2 protein |
Position | 4p15.2 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Slit-2-overexpressing breast cancer cells exhibit tumor suppressor capabilities through the novel mechanism of beta-catenin modulation. |
potential | Deletions in chromosome 4 differentially associated with the development of cervical cancer: evidence of slit2 as a candidate tumor suppressor gene. |
potential | SLIT2 is an excellent candidate tumor suppressor gene for colorectal cancer. |
reviewed | "SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers." |
| More detail of all 4 literatures about SLIT2 | |
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Pathways and Diseases |
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Pathway | Axon guidance mediated by Slit/Robo;PANTHER;P00008 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Glypican 1 network;PID Curated;200021 |
Pathway | Regulation of Commissural axon pathfinding by Slit and Robo;PID Reactome;500093 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Signaling by Robo receptor;PID Reactome;500092 |
Disease | Pulmonary fibrosis;FunDO |
Disease | Echocardiographic traits;NHGRI |
Disease | Cancer;FunDO |
Disease | CARDIOVASCULAR;GAD |
Disease | Echocardiographic traits;GAD |
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External Links |
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Links to Entrez Gene | 9353 |
Links to all GeneRIF Items | 9353 |
Links to iHOP | 9353 |
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Sequence Information |
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Nucleotide Sequence |
>9353 : length: 4590 atgcgcggcgttggctggcagatgctgtccctgtcgctggggttagtgctggcgatcctg aacaaggtggcaccgcaggcgtgcccggcgcagtgctcttgctcgggcagcacagtggac tgtcacgggctggcgctgcgcagcgtgcccaggaatatcccccgcaacaccgagagactg gatttaaatggaaataacatcacaagaattacgaagacagattttgctggtcttagacat ctaagagttcttcagcttatggagaataagattagcaccattgaaagaggagcattccag gatcttaaagaactagagagactgcgtttaaacagaaatcaccttcagctgtttcctgag ttgctgtttcttgggactgcgaagctatacaggcttgatctcagtgaaaaccaaattcag gcaatcccaaggaaagctttccgtggggcagttgacataaaaaatttgcaactggattac aaccagatcagctgtattgaagatggggcattcagggctctccgggacctggaagtgctc actctcaacaataacaacattactagactttctgtggcaagtttcaaccatatgcctaaa cttaggacttttcgactgcattcaaacaacctgtattgtgactgccacctggcctggctc tccgactggcttcgccaaaggcctcgggttggtctgtacactcagtgtatgggcccctcc cacctgagaggccataatgtagccgaggttcaaaaacgagaatttgtctgcagtggtcac cagtcatttatggctccttcttgtagtgttttgcactgccctgccgcctgtacctgtagc aacaatatcgtagactgtcgtgggaaaggtctcactgagatccccacaaatcttccagag accatcacagaaatacgtttggaacagaacacaatcaaagtcatccctcctggagctttc tcaccatataaaaagcttagacgaattgacctgagcaataatcagatctctgaacttgca ccagatgctttccaaggactacgctctctgaattcacttgtcctctatggaaataaaatc acagaactccccaaaagtttatttgaaggactgttttccttacagctcctattattgaat gccaacaagataaactgccttcgggtagatgcttttcaggatctccacaacttgaacctt ctctccctatatgacaacaagcttcagaccatcgccaaggggaccttttcacctcttcgg gccattcaaactatgcatttggcccagaacccctttatttgtgactgccatctcaagtgg ctagcggattatctccataccaacccgattgagaccagtggtgcccgttgcaccagcccc cgccgcctggcaaacaaaagaattggacagatcaaaagcaagaaattccgttgttcagct aaagaacagtatttcattccaggtacagaagattatcgatcaaaattaagtggagactgc tttgcggatctggcttgccctgaaaagtgtcgctgtgaaggaaccacagtagattgctct aatcaaaagctcaacaaaatcccggagcacattccccagtacactgcagagttgcgtctc aataataatgaatttaccgtgttggaagccacaggaatctttaagaaacttcctcaatta cgtaaaataaactttagcaacaataagatcacagatattgaggagggagcatttgaagga gcatctggtgtaaatgaaatacttcttacgagtaatcgtttggaaaatgtgcagcataag atgttcaagggattggaaagcctcaaaactttgatgttgagaagcaatcgaataacctgt gtggggaatgacagtttcataggactcagttctgtgcgtttgctttctttgtatgataat caaattactacagttgcaccaggggcatttgatactctccattctttatctactctaaac ctcttggccaatccttttaactgtaactgctacctggcttggttgggagagtggctgaga aagaagagaattgtcacgggaaatcctagatgtcaaaaaccatacttcctgaaagaaata cccatccaggatgtggccattcaggacttcacttgtgatgacggaaatgatgacaatagt tgctccccactttctcgctgtcctactgaatgtacttgcttggatacagtcgtccgatgt agcaacaagggtttgaaggtcttgccgaaaggtattccaagagatgtcacagagttgtat ctggatggaaaccaatttacactggttcccaaggaactctccaactacaaacatttaaca cttatagacttaagtaacaacagaataagcacgctttctaatcagagcttcagcaacatg acccagctcctcaccttaattcttagttacaaccgtctgagatgtattcctcctcgcacc tttgatggattaaagtctcttcgattactttctctacatggaaatgacatttctgttgtg cctgaaggtgctttcaatgatctttctgcattatcacatctagcaattggagccaaccct ctttactgtgattgtaacatgcagtggttatccgactgggtgaagtcggaatataaggag cctggaattgctcgttgtgctggtcctggagaaatggcagataaacttttactcacaact ccctccaaaaaatttacctgtcaaggtcctgtggatgtcaatattctagctaagtgtaac ccctgcctatcaaatccgtgtaaaaatgatggcacatgtaatagtgatccagttgacttt taccgatgcacctgtccatatggtttcaaggggcaggactgtgatgtcccaattcatgcc tgcatcagtaacccatgtaaacatggaggaacttgccacttaaaggaaggagaagaagat ggattctggtgtatttgtgctgatggatttgaaggagaaaattgtgaagtcaacgttgat gattgtgaagataatgactgtgaaaataattctacatgtgtcgatggcattaataactac acatgcctttgcccacctgagtatacaggtgagttgtgtgaggagaagctggacttctgt gcccaggacctgaacccctgccagcacgattcaaagtgcatcctaactccaaagggattc aaatgtgactgcacaccagggtacgtaggtgaacactgcgacatcgattttgacgactgc caagacaacaagtgtaaaaacggagcccactgcacagatgcagtgaacggctatacgtgc atatgccccgaaggttacagtggcttgttctgtgagttttctccacccatggtcctccct cgtaccagcccctgtgataattttgattgtcagaatggagctcagtgtatcgtcagaata aatgagccaatatgtcagtgtttgcctggctatcagggagaaaagtgtgaaaaattggtt agtgtgaattttataaacaaagagtcttatcttcagattccttcagccaaggttcggcct cagacgaacataacacttcagattgccacagatgaagacagcggaatcctcctgtataag ggtgacaaagaccatatcgcggtagaactctatcgggggcgtgttcgtgccagctatgac accggctctcatccagcttctgccatttacagtgtggagacaatcaatgatggaaacttc cacattgtggaactacttgccttggatcagagtctctctttgtccgtggatggtgggaac cccaaaatcatcactaacttgtcaaagcagtccactctgaattttgactctccactctat gtaggaggcatgccagggaagagtaacgtggcatctctgcgccaggcccctgggcagaac ggaaccagcttccacggctgcatccggaacctttacatcaacagtgagctgcaggacttc cagaaggtgccgatgcaaacaggcattttgcctggctgtgagccatgccacaagaaggtg tgtgcccatggcacatgccagcccagcagccaggcaggcttcacctgcgagtgccaggaa ggatggatggggcccctctgtgaccaacggaccaatgacccttgccttggaaataaatgc gtacatggcacctgcttgcccatcaatgcgttctcctacagctgtaagtgcttggagggc catggaggtgtcctctgtgatgaagaggaggatctgtttaacccatgccaggcgatcaag tgcaagcacgggaagtgcaggctttcaggtctggggcagccctactgtgaatgcagcagt ggatacacgggggacagctgtgatcgagaaatctcttgtcgaggggaaaggataagagat tattaccaaaagcagcagggctatgctgcttgccaaacaaccaagaaggtgtcccgatta gagtgcagaggtgggtgtgcaggagggcagtgctgtggaccgctgaggagcaagcggcgg aaatactctttcgaatgcactgacggctcctcctttgtggacgaggttgagaaagtggtg aagtgcggctgtacgaggtgtgtgtcctaa |
Protein Sequence |
>9353 : length: 1529 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR KYSFECTDGSSFVDEVEKVVKCGCTRCVS |