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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 9365 |
Name | KL |
Synonym | -;klotho;KL;klotho |
Definition | - |
Position | 13q12 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 3 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer. |
potential | our results suggest that klotho is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in colorectal cancer. |
potential | klotho is a potential tumor suppressor and an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer. |
| More detail of all 3 literatures about KL | |
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Pathways and Diseases |
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Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Disease | bone density and spondylosis;GAD |
Disease | angina, vasospastic atherosclerosis, coronary;GAD |
Disease | Coronary artery disease, susceptibility to;OMIM |
Disease | cholesterol, HDL;GAD |
Disease | blood pressure, arterial body mass glucose insulin lipids;GAD |
Disease | spondylosis, lumbar;GAD |
Disease | AGING;GAD |
Disease | longevity;GAD |
Disease | Cardiomyopathies;GAD |
Disease | Coronary Stenosis;GAD |
Disease | stroke, ischemic;GAD |
Disease | atherosclerosis, coronary;GAD |
Disease | Aseptic necrosis of bone;FunDO |
Disease | osteoarthritis;GAD |
Disease | METABOLIC;GAD |
Disease | Calcinosis;GAD |
Disease | Tumoral calcinosis, hyperphosphatemic;OMIM |
Disease | Stroke;FunDO |
Disease | aging;GAD |
Disease | bone density;GAD |
Disease | age-related skeletal disorders;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | CHEMDEPENDENCY;GAD |
Disease | bone density osteoarthritis osteoporosis;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | Kidney failure;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | blood pressure, arterial;GAD |
Disease | smoking cessation;GAD |
Disease | memory impairment;GAD |
Disease | Spondylarthropathies;FunDO |
Disease | Arthritis;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 9365 |
Links to all GeneRIF Items | 9365 |
Links to iHOP | 9365 |
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Sequence Information |
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Nucleotide Sequence |
>9365 : length: 3039 atgcccgccagcgccccgccgcgccgcccgcggccgccgccgccgtcgctgtcgctgctg ctggtgctgctgggcctgggcggccgccgcctgcgtgcggagccgggcgacggcgcgcag acctgggcccgtttctcgcggcctcctgcccccgaggccgcgggcctcttccagggcacc ttccccgacggcttcctctgggccgtgggcagcgccgcctaccagaccgagggcggctgg cagcagcacggcaagggtgcgtccatctgggatacgttcacccaccaccccctggcaccc ccgggagactcccggaacgccagtctgccgttgggcgccccgtcgccgctgcagcccgcc accggggacgtagccagcgacagctacaacaacgtcttccgcgacacggaggcgctgcgc gagctcggggtcactcactaccgcttctccatctcgtgggcgcgagtgctccccaatggc agcgcgggcgtccccaaccgcgaggggctgcgctactaccggcgcctgctggagcggctg cgggagctgggcgtgcagcccgtggtcaccctgtaccactgggacctgccccagcgcctg caggacgcctacggcggctgggccaaccgcgccctggccgaccacttcagggattacgcg gagctctgcttccgccacttcggcggtcaggtcaagtactggatcaccatcgacaacccc tacgtggtggcctggcacggctacgccaccgggcgcctggcccccggcatccggggcagc ccgcggctcgggtacctggtggcgcacaacctcctcctggctcatgccaaagtctggcat ctctacaatacttctttccgtcccactcagggaggtcaggtgtccattgccctaagctct cactggatcaatcctcgaagaatgaccgaccacagcatcaaagaatgtcaaaaatctctg gactttgtactaggttggtttgccaaacccgtatttattgatggtgactatcccgagagc atgaagaataacctttcatctattctgcctgattttactgaatctgagaaaaagttcatc aaaggaactgctgacttttttgctctttgctttggacccaccttgagttttcaacttttg gaccctcacatgaagttccgccaattggaatctcccaacctgaggcaactgctttcctgg attgaccttgaatttaaccatcctcaaatatttattgtggaaaatggctggtttgtctca gggaccaccaagagagatgatgccaaatatatgtattacctcaaaaagttcatcatggaa accttaaaagccatcaagctggatggggtggatgtcatcgggtataccgcatggtccctc atggatggtttcgagtggcacagaggttacagcatcaggcgtggactcttctatgttgac tttctaagccaggacaagatgttgttgccaaagtcttcagccttgttctaccaaaagctg atagagaaaaatggcttccctcctttacctgaaaatcagcccctagaagggacatttccc tgtgactttgcttggggagttgttgacaactacattcaagtagataccactctgtctcag tttaccgacctgaatgtttacctgtgggatgtccaccacagtaaaaggcttattaaagtg gatggggttgtgaccaagaagaggaaatcctactgtgttgactttgctgccatccagccc cagatcgctttactccaggaaatgcacgttacacattttcgcttctccctggactgggcc ctgattctccctctgggtaaccagtcccaggtgaaccacaccatcctgcagtactatcgc tgcatggccagcgagcttgtccgtgtcaacatcaccccagtggtggccctgtggcagcct atggccccgaaccaaggactgccgcgcctcctggccaggcagggcgcctgggagaacccc tacactgccctggcctttgcagagtatgcccgactgtgctttcaagagctcggccatcac gtcaagctttggataacgatgaatgagccgtatacaaggaatatgacatacagtgctggc cacaaccttctgaaggcccatgccctggcttggcatgtgtacaatgaaaagtttaggcat gctcagaatgggaaaatatccatagccttgcaggctgattggatagaacctgcctgccct ttctcccaaaaggacaaagaggtggctgagagagttttggaatttgacattggctggctg gctgagcccattttcggctctggagattatccatgggtgatgagggactggctgaaccaa agaaacaattttcttcttccttatttcactgaagatgaaaaaaagctaatccagggtacc tttgactttttggctttaagccattataccaccatccttgtagactcagaaaaagaagat ccaataaaatacaatgattacctagaagtgcaagaaatgaccgacatcacgtggctcaac tcccccagtcaggtggcggtagtgccctgggggttgcgcaaagtgctgaactggctgaag ttcaagtacggagacctccccatgtacataatatccaatggaatcgatgacgggctgcat gctgaggacgaccagctgagggtgtattatatgcagaattacataaacgaagctctcaaa gcccacatactggatggtatcaatctttgcggatactttgcttattcgtttaacgaccgc acagctccgaggtttggcctctatcgttatgctgcagatcagtttgagcccaaggcatcc atgaaacattacaggaaaattattgacagcaatggtttcccgggcccagaaactctggaa agattttgtccagaagaattcaccgtgtgtactgagtgcagtttttttcacacccgaaag tctttactggctttcatagcttttctattttttgcttctattatttctctctcccttata ttttactactcgaagaaaggcagaagaagttacaaatag |
Protein Sequence |
>9365 : length: 1012 MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGT FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS HWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFI KGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVS GTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVD FLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQ FTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWA LILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENP YTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRH AQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQ RNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLN SPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALK AHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLE RFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK |