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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 9368 |
Name | SLC9A3R1 |
Synonym | EBP50|NHERF|NHERF1|NPHLOP2;solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1;SLC9A3R1;solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 |
Definition | NHERF-1|Na(+)/H(+) exchange regulatory cofactor NHE-RF1|Na+/H+ exchange regulatory co-factor|ezrin-radixin-moesin binding phosphoprotein-50|ezrin-radixin-moesin-binding phosphoprotein 50|regulatory cofactor of Na(+)/H(+) exchanger|sodium-hydrogen exchange |
Position | 17q25.1 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Findings define a tumor suppressor role for NHERF1 at the plasma membrane, and reveal a novel mechanism for PI3K/Akt activation through PTEN inactivation caused by a loss of membrane-localized NHERF1." |
reviewed | EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity. |
potential | NHERF to be a candidate tumor suppressor gene in human breast carcinoma that may be interconnected to the SYK and MERLIN suppressors. |
reviewed | Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function. |
| More detail of all 4 literatures about SLC9A3R1 | |
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Pathways and Diseases |
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Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway;PID BioCarta;100205 |
Disease | HEMATOLOGICAL;GAD |
Disease | Cystic fibrosis;FunDO |
Disease | IMMUNE;GAD |
Disease | psoriasis;GAD |
Disease | Nephrolithiasis/osteoporosis, hypophosphatemic, 2;OMIM |
Disease | fibrinogen;GAD |
Disease | Breast cancer;FunDO |
Disease | Liver cancer;FunDO |
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External Links |
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Links to Entrez Gene | 9368 |
Links to all GeneRIF Items | 9368 |
Links to iHOP | 9368 |
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Sequence Information |
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Nucleotide Sequence |
>9368 : length: 1077 atgagcgcggacgcagcggccggggcgcccctgccccggctctgctgcctggagaagggt ccgaacggctacggcttccacctgcacggggagaagggcaagttgggccagtacatccgg ctggtggagcccggctcgccggccgagaaggcggggctgctggcgggggaccggctggtg gaggtgaacggcgaaaacgtggagaaggagacccaccagcaggtggtgagccgcatccgc gccgcactcaacgccgtgcgcctgctggtggtcgaccccgagacggacgagcagctgcag aagctcggcgtccaggtccgagaggagctgctgcgcgcccaggaagcgccggggcaggcc gagccgccggccgccgccgaggtgcagggggctggcaacgaaaatgagcctcgcgaggcc gacaagagccacccggagcagcgcgagcttcggcctcggctctgtaccatgaagaagggc cccagtggctatggcttcaacctgcacagcgacaagtccaagccaggccagttcatccgg tcagtggacccagactccccggctgaggcttcagggctccgggcccaggatcgcattgtg gaggtgaacggggtctgcatggaggggaagcagcatggggacgtggtgtccgccatcagg gctggcggggacgagaccaagctgctggtggtggacagggaaactgacgagttcttcaag aaatgcagagtgatcccatctcaggagcacctgaatggtcccctgcctgtgcccttcacc aatggggagatacagaaggagaacagtcgtgaagccctggcagaggcagccttggagagc cccaggccagccctggtgagatccgcctccagtgacaccagcgaggagctgaattcccaa gacagccccccaaaacaggactccacagcgccctcgtctacctcctcctccgaccccatc ctagacttcaacatctccctggccatggccaaagagagggcccaccagaaacgcagcagc aaacgggccccgcagatggactggagcaagaaaaacgaactcttcagcaacctctga |
Protein Sequence |
>9368 : length: 358 MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL |