Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

9521

Name

EEF1E1

Synonym

AIMP3|P18;eukaryotic translation elongation factor 1 epsilon 1;EEF1E1;eukaryotic translation elongation factor 1 epsilon 1

Definition

ARS-interacting multifunctional protein 3|aminoacyl tRNA synthetase complex-interacting multifunctional protein 3|eukaryotic translation elongation factor 1 epsilon-1|multisynthase complex auxiliary component p18|p18 component of aminoacyl-tRNA synthetase

Position

6p24.3

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 6 PubMed records as below.

Evidence Status

Description

reviewed

Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3.

reviewed

Decreased expression of AIMP3 in gastric and colorectal cancer tissues suggests that down-regulation of this protein may be related to inactivation of the tumor suppressor functions of AIMP proteins and might play a role in the development of GC and CRC.

reviewed

"Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers."

reviewed

analysis of the three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with.

reviewed

p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR-mediated p53 activation.

reviewed

Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.
More detail of all 6 literatures about EEF1E1

Pathways and Diseases

Pathway

Cytosolic tRNA aminoacylation;PID Reactome;500660

Pathway

Gene Expression;Reactome;REACT:71

External Links

Links to Entrez Gene

9521

Links to all GeneRIF Items

9521

Links to iHOP

9521

Sequence Information

Nucleotide Sequence

>9521 : length: 420
atggcggcggccgcagagttgtcgctactggagaagtccctgggactgagtaaggggaat
aaatacagtgctcagggcgagcgacagattccagttcttcagacaaacaatggtccaagt
ctaacaggattgactactatagcagctcatctagtcaagcaagccaacaaagaatatttg
ctggggagtactgcagaagaaaaagcaatcgttcagcagtggttagaatacagggtcact
caagtagatgggcactccagtaaaaatgacatccacacactgttgaaggatcttaattca
tatcttgaagataaagtctaccttacagggtataactttacattagcagatatactattg
tactatggacttcatcgctttataataaggaagctgaggcacacagaggtagggaactaa

Protein Sequence

>9521 : length: 139
MAAAAELSLLEKSLGLSKGNKYSAQGERQIPVLQTNNGPSLTGLTTIAAHLVKQANKEYL
LGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYLTGYNFTLADILL
YYGLHRFIIRKLRHTEVGN



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