Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

9770

Name

RASSF2

Synonym

CENP-34|RASFADIN;Ras association (RalGDS/AF-6) domain family member 2;RASSF2;Ras association (RalGDS/AF-6) domain family member 2

Definition

Ras association (RalGDS/AF-6) domain family 2|centromere protein 34|ras association domain-containing protein 2

Position

20p13

Gene Type

protein-coding

Source

Count: 3; Pubmed_search,Generif,UniProt

Literature support

Count: 7 PubMed records as below.

Evidence Status

Description

potential

Results suggest that RASSF2 encodes a novel epigenetically inactivated candidate tumor suppressor gene in thyroid carcinogenesis.

reviewed

Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity.

reviewed

"Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2."

reviewed

The epigenetic silencing of tumor suppressor genes involved in the Ras/PI3K/AKT pathway plays an important role in oral squamous cell carcinoma radioresistance.

reviewed

Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals.

reviewed

RASSF2 is a novel tumor suppressor gene that regulates Ras signaling and plays a pivotal role in the early stages of colorectal tumorigenesis.

reviewed

RASSF2 is a new member of the RASSF1 family of Ras effectors/tumor suppressors that exhibits a specificity for interacting with K-Ras.
More detail of all 7 literatures about RASSF2

External Links

Links to Entrez Gene

9770

Links to all GeneRIF Items

9770

Links to iHOP

9770

Sequence Information

Nucleotide Sequence

>9770 : length: 981
atggactacagccaccaaacgtccctagtcccatgtggacaagataaatacatttccaaa
aatgaacttctcttgcatctgaagacctacaacttgtactatgaaggccagaatttacag
ctccggcaccgggaggaagaagacgagttcattgtggaggggctcctgaacatctcctgg
ggcctgcgccggcccattcgcctgcagatgcaggatgacaacgaacgcattcgaccccct
ccatcctcctcctcctggcactctggctgtaacctgggggctcagggaaccactctgaag
cccctgactgtgcccaaagttcagatctcagaggtggatgccccgccggagggtgaccag
atgccaagctccacagactccaggggcctgaagcccctgcaggaggacaccccacagctg
atgcgcacacgcagtgatgttggggtgcgtcgccgtggcaatgtgaggacgcctagtgac
cagcggcgaatcagacgccaccgcttctccatcaacggccatttctacaaccataagaca
tccgtgttcacaccagcctatggctctgtcaccaacgtccgcatcaacagcaccatgacc
accccacaggtcctgaagctgctgctcaacaaatttaagattgagaattcagcagaggag
tttgccttgtacgtggtccatacgagtggtgagaaacagaagctgaaggccaccgattac
ccgctgattgcccgaatcctccagggcccatgtgagcagatctccaaagtgttcctaatg
gagaaggaccaggtggaggaagtcacctacgacgtggcccagtatataaagttcgagatg
ccggtacttaaaagcttcattcagaagctccaggaggaagaagatcgggaagtaaagaag
ctgatgcgcaagtacaccgtgctccggctaatgattcgacagaggctggaggagatagcc
gagaccccagcaacaatctga

Protein Sequence

>9770 : length: 326
MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISW
GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAPPEGDQ
MPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHFYNHKT
SVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY
PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK
LMRKYTVLRLMIRQRLEEIAETPATI



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