Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7249

Name

TSC2

Synonymous

LAM|TSC4;tuberous sclerosis 2;TSC2;tuberous sclerosis 2

Definition

tuberin|tuberous sclerosis 2 protein

Position

16p13.3

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction

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Interaction Type

Interactor

Data Source

interacts with

 MAPK1BIOGRID; PUBMED:15851026;

interacts with

 TBC1D7BIOGRID; PUBMED:17658474;

interacts with

 RPS6KA1BIOGRID; PUBMED:15342917;

interacts with

 RPS6KA1BIOGRID; PUBMED:15757502;

interacts with

 AXIN1BIOGRID; PUBMED:12511557;

interacts with

 GSK3BBIOGRID; PUBMED:12511557;

interacts with

 GSK3BBIOGRID; PUBMED:16959574;

interacts with

 CAV1BIOGRID; PUBMED:12147258;

interacts with

 FBXW5BIOGRID; PUBMED:18381890;

interacts with

 PTK2BIOGRID; PUBMED:17043358;

interacts with

 FOXO1BIOGRID; PUBMED:17077083;

interacts with

 CDKN1BBIOGRID; PUBMED:15355997;

interacts with

 CCND3BIOGRID; PUBMED:16357142;

interacts with

 CCND2BIOGRID; PUBMED:16357142;

interacts with

 RAP1ABIOGRID; PUBMED:12147258;

interacts with

 RAP1ABIOGRID; PUBMED:12842888;

interacts with

 RAB5ABIOGRID; PUBMED:12147258;

interacts with

 RALABIOGRID; PUBMED:12842888;

interacts with

 RHEBBIOGRID; PUBMED:12771962;

interacts with

 RHEBBIOGRID; PUBMED:12820960;

interacts with

 RHEBBIOGRID; PUBMED:12842888;

interacts with

 RHEBBIOGRID; PUBMED:12869586;

interacts with

 RHEBBIOGRID; PUBMED:15854902;

interacts with

 RHEBBIOGRID; PUBMED:17077083;

interacts with

 YWHABBIOGRID; PUBMED:12176984;

interacts with

 YWHABBIOGRID; PUBMED:12364343;

interacts with

 YWHABBIOGRID; PUBMED:12468542;

interacts with

 YWHABBIOGRID; PUBMED:12582162;

interacts with

 YWHABBIOGRID; PUBMED:16636147;

interacts with

 YWHAZBIOGRID; PUBMED:12176984;

interacts with

 PAMBIOGRID; PUBMED:14559897;

interacts with

 YWHAQBIOGRID; PUBMED:17353931;

interacts with

 PRKAA1BIOGRID; PUBMED:14651849;

interacts with

 PRKAA1BIOGRID; PUBMED:15261145;

interacts with

 AKT1BIOGRID; PUBMED:12167664;

interacts with

 AKT1BIOGRID; PUBMED:15342917;

interacts with

 PLK1BIOGRID; PUBMED:16339216;

interacts with

 UBE3ABIOGRID; PUBMED:15175323;

interacts with

 UBE3ABIOGRID; PUBMED:18298802;

interacts with

 TSC1BIOGRID; PUBMED:10807585;

interacts with

 TSC1BIOGRID; PUBMED:10915759;

interacts with

 TSC1BIOGRID; PUBMED:11175345;

interacts with

 TSC1BIOGRID; PUBMED:11290735;

interacts with

 TSC1BIOGRID; PUBMED:11741832;

interacts with

 TSC1BIOGRID; PUBMED:11741833;

interacts with

 TSC1BIOGRID; PUBMED:12167664;

interacts with

 TSC1BIOGRID; PUBMED:12176984;

interacts with

 TSC1BIOGRID; PUBMED:12511557;

interacts with

 TSC1BIOGRID; PUBMED:14551205;

interacts with

 TSC1BIOGRID; PUBMED:14651849;

interacts with

 TSC1BIOGRID; PUBMED:15340059;

interacts with

 TSC1BIOGRID; PUBMED:15851026;

interacts with

 TSC1BIOGRID; PUBMED:15963462;

interacts with

 TSC1BIOGRID; PUBMED:16339216;

interacts with

 TSC1BIOGRID; PUBMED:16424383;

interacts with

 TSC1BIOGRID; PUBMED:16636147;

interacts with

 TSC1BIOGRID; PUBMED:17077083;

interacts with

 TSC1BIOGRID; PUBMED:17658474;

interacts with

 TSC1BIOGRID; PUBMED:9580671;

interacts with

 CCND1BIOGRID; PUBMED:16357142;

interacts with

 MAPK1HPRD; PUBMED:15851026;

interacts with

 MAPK3HPRD; PUBMED:15342917;

interacts with

 MAPKAPK2HPRD; PUBMED:12582162;

interacts with

 TBC1D7HPRD; PUBMED:17658474;

interacts with

 NEK1HPRD; PUBMED:14690447;

interacts with

 RPS6KA1HPRD; PUBMED:15342917;

interacts with

 AXIN1HPRD; PUBMED:12511557;

interacts with

 ESR1HPRD; PUBMED:15851513;

interacts with

 GSK3BHPRD; PUBMED:12511557;

interacts with

 FBXW5HPRD; PUBMED:18381890;

interacts with

 FBXL6HPRD; PUBMED:18381890;

interacts with

 CDKN1BHPRD; PUBMED:15355997;

interacts with

 DOCK7HPRD; PUBMED:15963462;

interacts with

 CUL4AHPRD; PUBMED:18381890;

interacts with

 DDB1HPRD; PUBMED:18381890;

interacts with

 RABEP1HPRD; PUBMED:9045618;

interacts with

 RAB5AHPRD; PUBMED:9045618;

interacts with

 RHEBHPRD; PUBMED:12842888;

interacts with

 YWHAGHPRD; PUBMED:12438239;

interacts with

 AKT2HPRD; PUBMED:12167664;

interacts with

 YWHABHPRD; PUBMED:12438239;

interacts with

 YWHAZHPRD; PUBMED:12176984;

interacts with

 YWHAEHPRD; PUBMED:12438239;

interacts with

 PAMHPRD; PUBMED:14559897;

interacts with

 YWHAHHPRD; PUBMED:12438239;

interacts with

 YWHAQHPRD; PUBMED:12364343;

interacts with

 YWHAQHPRD; PUBMED:12438239;

interacts with

 AKT3HPRD; PUBMED:12167664;

interacts with

 AKT1HPRD; PUBMED:12438239;

interacts with

 SFNHPRD; PUBMED:12438239;

interacts with

 PLK1HPRD; PUBMED:16339216;

interacts with

 PPP2CAHPRD; PUBMED:17163575;

interacts with

 SMAD2HPRD; PUBMED:15066998;

interacts with

 CCND1HPRD; PUBMED:16357142;

interacts with

 MYL12AMINT; PUBMED:20618440;

interacts with

 TUBB2AMINT; PUBMED:20618440;

interacts with

 TGIF2LYMINT; PUBMED:20618440;

interacts with

 TPM1MINT; PUBMED:20618440;

interacts with

 TTNMINT; PUBMED:20618440;

interacts with

 MYH9MINT; PUBMED:20618440;

interacts with

 MYH3MINT; PUBMED:20618440;

interacts with

 MYL3MINT; PUBMED:20618440;

interacts with

 MYH11MINT; PUBMED:20618440;

interacts with

 MYH13MINT; PUBMED:20618440;

interacts with

 MYH7MINT; PUBMED:20618440;

interacts with

 MYH2MINT; PUBMED:20618440;

interacts with

 MYLK2MINT; PUBMED:20618440;

interacts with

 LMNAMINT; PUBMED:20618440;

interacts with

 CACNA1SMINT; PUBMED:20618440;

interacts with

 BANK1MINT; PUBMED:20618440;

interacts with

 CALM1MINT; PUBMED:20618440;

interacts with

 ATP5A1MINT; PUBMED:20618440;

interacts with

 HIST1H2BDMINT; PUBMED:20618440;

interacts with

 HIST1H1CMINT; PUBMED:20618440;

interacts with

 H2AFXMINT; PUBMED:20618440;

interacts with

 HIST1H1DMINT; PUBMED:20618440;

interacts with

 HIST1H2AGMINT; PUBMED:20618440;

interacts with

 HNRNPCMINT; PUBMED:20618440;

interacts with

 H1F0MINT; PUBMED:20618440;

interacts with

 HIST1H1TMINT; PUBMED:20618440;

interacts with

 DAPK1MINT; PUBMED:21134130;

interacts with

 DESMINT; PUBMED:20618440;

interacts with

 CBLMINT; PUBMED:20618440;

interacts with

 KRT8MINT; PUBMED:20618440;

interacts with

 KRT17MINT; PUBMED:20618440;

interacts with

 RALYMINT; PUBMED:20618440;

interacts with

 HNRNPA2B1MINT; PUBMED:20618440;

interacts with

 YWHAGMINT; PUBMED:12438239;

interacts with

 YWHAGMINT; PUBMED:20618440;

interacts with

 YWHABMINT; PUBMED:12438239;

interacts with

 YWHABMINT; PUBMED:12468542;

interacts with

 YWHABMINT; PUBMED:12582162;

interacts with

 YWHABMINT; PUBMED:15324660;

interacts with

 YWHABMINT; PUBMED:20169078;

interacts with

 YWHAZMINT; PUBMED:12176984;

interacts with

 YWHAZMINT; PUBMED:12438239;

interacts with

 YWHAZMINT; PUBMED:12468542;

interacts with

 YWHAZMINT; PUBMED:15161933;

interacts with

 YWHAZMINT; PUBMED:16636147;

interacts with

 YWHAZMINT; PUBMED:20618440;

interacts with

 ACTBMINT; PUBMED:20618440;

interacts with

 YWHAEMINT; PUBMED:12438239;

interacts with

 YWHAEMINT; PUBMED:20618440;

interacts with

 ACTA2MINT; PUBMED:20618440;

interacts with

 ANKRD18AMINT; PUBMED:20618440;

interacts with

 ACTN3MINT; PUBMED:20618440;

interacts with

 YWHAHMINT; PUBMED:12438239;

interacts with

 YWHAHMINT; PUBMED:20618440;

interacts with

 YWHAQMINT; PUBMED:12438239;

interacts with

 YWHAQMINT; PUBMED:20618440;

interacts with

 ACTG1MINT; PUBMED:20618440;

interacts with

 ACTN2MINT; PUBMED:20618440;

interacts with

 SFNMINT; PUBMED:12438239;

interacts with

 KRT18MINT; PUBMED:20618440;

interacts with

 USP42MINT; PUBMED:20618440;

interacts with

 VASPMINT; PUBMED:20618440;

interacts with

 VIMMINT; PUBMED:20618440;

interacts with

 TSC1MINT; PUBMED:20412061;

interacts with

 TSC1MINT; PUBMED:21134130;

interacts with

 TSC1MINT; PUBMED:9580671;

interacts with

 RPS3MINT; PUBMED:20618440;

interacts with

 CEP250MINT; PUBMED:20618440;

Metabolic Interaction

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Interaction Type

Interactor

Data Source

sequential catalysis

 TSC2IMID; PUBMED:7608212;

metabolic catalysis

 MAXNCI_NATURE; PUBMED:18056446;

metabolic catalysis

 MYCNCI_NATURE; PUBMED:18056446;

metabolic catalysis

 TP53NCI_NATURE; PUBMED:17409411;

Signaling Interaction

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Interaction Type

Interactor

Data Source

state change

 MAPKAPK2NCI_NATURE; PUBMED:12582162;

state change

 RPS6KA1NCI_NATURE; PUBMED:15342917;

state change

 GSK3BNCI_NATURE; PUBMED:16959574;

reacts with

 DDIT4NCI_NATURE; PUBMED:15545625;PUBMED:18198340;

reacts with

 IKBKBNCI_NATURE; PUBMED:17693255;

state change

 AKT1NCI_NATURE; PUBMED:12820960;PUBMED:12172553;PUBMED:17386266;

reacts with

 TSC2NCI_NATURE; PUBMED:12582162;

reacts with

 TSC2NCI_NATURE; PUBMED:12820960;PUBMED:12172553;PUBMED:17386266;

reacts with

 TSC2NCI_NATURE; PUBMED:14651849;

reacts with

 TSC2NCI_NATURE; PUBMED:15342917;

reacts with

 TSC2NCI_NATURE; PUBMED:15545625;PUBMED:18198340;

reacts with

 TSC2NCI_NATURE; PUBMED:15851026;

reacts with

 TSC2NCI_NATURE; PUBMED:16959574;

reacts with

 TSC2NCI_NATURE; PUBMED:17693255;

reacts with

 TSC1NCI_NATURE; PUBMED:12820960;PUBMED:12172553;PUBMED:17386266;

reacts with

 TSC1NCI_NATURE; PUBMED:14651849;

reacts with

 TSC1NCI_NATURE; PUBMED:15342917;

reacts with

 TSC1NCI_NATURE; PUBMED:15545625;PUBMED:18198340;

reacts with

 TSC1NCI_NATURE; PUBMED:15851026;

reacts with

 TSC1NCI_NATURE; PUBMED:16959574;

reacts with

 TSC1NCI_NATURE; PUBMED:17693255;

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