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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 2113 |
Name | ETS1 |
Synonymous | ETS-1|EWSR2;v-ets erythroblastosis virus E26 oncogene homolog 1 (avian);ETS1;v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) |
Definition | Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1|ets protein|p54|protein C-ets-1|v-ets avian erythroblastosis virus E2 oncogene homolog 1 |
Position | 11q23.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
c-Ets-1(h) --> Py(PA) (DNA binding). | c-Ets-1(h) --> TCR-alpha(h) (DNA binding; transregulation). | c-Ets-1(h) --> TIMP-1(h) (DNA binding). | c-Ets-1(h) --> CD8A(h) (DNA binding). | c-Ets-1(h) --> MMP1(h) (DNA binding). | c-Ets-1(h) --> ITGAX(h) (DNA binding; transactivation). | c-Ets-1(h) --> PTHLH(h) (DNA binding; transactivation). | c-Ets-1(h) --> TNF(h) (DNA binding; transactivation). | c-Ets-1(h) --> FOSL1(h) (DNA binding; transactivation). | c-Ets-1(h) --> CD53 (h) (DNA binding; transactivation). | c-Ets-1(h) --> IL2RB(h) (DNA binding; transactivation). | c-Ets-1(h) --> TCR-Vbeta 8.1(h) (DNA binding; transactivation). | c-Ets-1(h) --> TFAP2A(h) (DNA binding; transactivation) | c-Ets-1(h) --> NFKB1(h) (DNA binding; transactivation) | c-Ets-1(h) --> CSNK2B(h) (DNA binding; transactivation). | c-Ets-1(h) --> SPP1(r) (DNA binding; transactivation). | c-Ets-1(h) + Pit-1B(h) <==> c-Ets-1(h):Pit-1B(h) (binding) | c-Ets-1(h) + Sp100(h) <==> c-Ets-1(h):Sp100(h) (binding) | Sp100-A(h) + c-Ets-1(h) <==> Sp100-A(h):c-Ets-1(h) (binding) | Daxx(h) + c-Ets-1(h) <==> Daxx(h):c-Ets-1(h) (binding) | Daxx(h) + c-Ets-1(h) <==> Daxx(h):c-Ets-1(h) (binding) | c-Ets-1(h) --/ TFRC(h) (DNA binding; transrepression). | c-Ets-1(h) --> ECE1(h) (DNA binding). | brca1(m.s.) + c-Ets-1(h) <==> brca1(m.s.):c-Ets-1(h) (binding) | ETS1(h) --> c-Ets-1(h) (expression). | Ets-1 deltaVII(h) --> Py(PA) (DNA binding). | ETS1(h) --> Ets-1 deltaVII(h) (expression). | c-Ets-1(h) + c-Ets-2(h) <==> c-Ets-1(h):c-Ets-2(h) (binding) [re. | c-Jun(m) + c-Ets-1(h) <==> c-Jun(m):c-Ets-1(h) (binding) [re. | JunB(m) + c-Ets-1(h) <==> JunB(m):c-Ets-1(h) (binding) [re. | JunD(m) + c-Ets-1(h) <==> JunD(m):c-Ets-1(h) (binding) [re. | SRC-1(h) + c-Ets-1(h) <==> SRC-1(h):c-Ets-1(h) (binding) | SRC3(h) + c-Ets-1(h) <==> SRC3(h):c-Ets-1(h) (binding) | NCOR(h) + c-Ets-1(h) <==> NCOR(h):c-Ets-1(h) (binding) | c-Ets-1(h) + ATP --GSK3beta(m.s.)--> c-Ets-1(h){p} + ADP (phosphorylation) | Daxx(h) + c-Ets-1(h) <==> Daxx(h):c-Ets-1(h) (binding) | EAPII(h) + c-Ets-1(h) <==> EAPII(h):c-Ets-1(h) (binding) | c-Ets-1(h) + acetyl-CoA --> c-Ets-1(h){aceK} + CoA (acetylation) | c-Ets-1(h) + 2 ATP --> c-Ets-1(h){pS}{pT} + 2 ADP (phosphorylation) | c-Ets-1(h) --> CASP1(h) (DNA binding; transactivation). | c-Ets-1(h) --> KIR3DL1(h) (DNA binding; transactivation). | c-Ets-1(h) --> Pf4(r) (DNA binding). | c-Ets-1(h) --> WAS(h) (DNA binding). | c-Ets-1(h) --> CD244(h) (DNA binding). | c-Ets-1(h) --> PTHLH(h) (DNA binding; transactivation). | c-Ets-1(h) --> PSEN1(h) (DNA binding; transactivation). | c-Ets-1(h) + p53(h) <==> c-Ets-1(h):p53(h) (binding) | c-Ets-1(h) --> CHUK(h) (DNA binding). | c-Ets-1(h) --> CDC2L2(h) (DNA binding). | c-Ets-1(h) --> ERBB2(h) (DNA binding). | c-Ets-1(h) --> TFRC(h) (DNA binding). | c-Ets-1(h) --> SP1(h) (transactivation) | c-Ets-1(h) --> MMP1(h) (DNA binding). | c-Ets-1(h) --> CXCR4(h) (DNA binding). | c-Ets-1(h) --> AIRE(h) (DNA binding). | c-Ets-1(h) --> CYGB(h) (DNA binding). | c-Ets-1(h) --> PKD1(h) (DNA binding). | c-Ets-1(h) --> Itgav(m) (transactivation) [re. | c-Ets-1(h) --> IL-5(m) (DNA binding; transactivation). | c-Ets-1(h) --> COL1A2(h) (DNA binding). | c-Ets-1(h) --> THBD(h) (DNA binding). | c-Ets-1(h) --> GRPR(h) (DNA binding). | c-Ets-1(h) --> ECE1(h) (DNA binding). | c-Ets-1(h) --> C3AR1(h) (DNA binding). | c-Ets-1(h) --> MGAT5(h) (DNA binding). | c-Ets-1(h) --> Atp2a3(m) (DNA binding). | c-Ets-1(h) --> ANGPT2(h) (transactivation) | c-Ets-1(h) --> prl(h) (DNA binding). | c-Ets-1(h) --> SOCS1(h) (DNA binding). | c-Ets-1(h) --> GHR(h) (DNA binding). | c-Ets-1(h) --> F13A1(h) (DNA binding). | c-Ets-1(h) --> SERPINE1(h) (DNA binding). | c-Ets-1(h) --> IL10(h) (DNA binding). | c-Ets-1(h) --> TNFSF14(h) (DNA binding). | c-Ets-1(h) --> c-myb(h) (DNA binding). | c-Ets-1(h) --> TBXA2R(h) (DNA binding). | ETS1(h) --> c-Ets-1(h) (expression). | EGF(m.s.) --> c-Ets-1(h) (increase of abundance) | ETS1(h) --> Ets-1(h) (expression). | hsa-miR-155 --/ Ets-1(h) (translational repression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
38 | Phosphothreonine (by MAPK) (Bysimilarity). | Swiss-Prot 53.0 | 205 | Phosphotyrosine. | Swiss-Prot 53.0 | 223 | Phosphotyrosine. | Swiss-Prot 53.0 | 15 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (Bysimilarity). | Swiss-Prot 53.0 | 227 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (Bysimilarity). | Swiss-Prot 53.0 | 205 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 223 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 257 | Phosphoserine (CaM-KIIalpha) | 12475968 | Phospho.ELM 6.0 | 251 | Phosphoserine (CaM-KIIalpha) | 12475968 | Phospho.ELM 6.0 | 282 | Phosphoserine (CaM-KIIalpha) | 12475968 | Phospho.ELM 6.0 | 285 | Phosphoserine (CaM-KIIalpha) | 12475968 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr11 |
Promoter: 127896871 - 127898871 | Agilent_014791 |
chr11 |
Promoter: 127896871 - 127898871 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 127896871 - 127898871 | GSE27584 |
chr11 |
Promoter: 127896871 - 127898871 | Agilent_014791_44K |