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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 3728 |
Name | JUP |
Synonymous | ARVD12|CTNNG|DP3|DPIII|PDGB|PKGB;junction plakoglobin;JUP;junction plakoglobin |
Definition | catenin (cadherin-associated protein), gamma (80kD)|catenin (cadherin-associated protein), gamma 80kDa|catenin gamma|desmoplakin III|desmoplakin-3|gamma-catenin |
Position | 17q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
alpha-catenin1(h) + beta-catenin(h) + E-cadherin(h) + p120CAS(h) + plakoglobin(h) <==> alpha-catenin1(h):beta-catenin(h):E-cadherin(h):plakoglobin(h):p120CAS(h) (binding) | alpha-catenin1(h) + apc(h) + beta-catenin(h) + plakoglobin(h) <==> alpha-catenin1(h):apc(h):beta-catenin(h):plakoglobin(h) (binding) | muc1(h) + plakoglobin(h) <==> muc1(h):plakoglobin(h) (binding) | ErbB2(h) + plakoglobin(h) <==> ErbB2(h):plakoglobin(h) (binding) | plakoglobin(h) + n ubiquitin(m) --beta-TrCP1(h)--> plakoglobin(h){ub(n)} (ubiquitination) | beta-TrCP1(h) + plakoglobin(h) <==> beta-TrCP1(h):plakoglobin(h) (binding) | plakoglobin(h) + ATP --fer(h)--> plakoglobin(h){pY549} + ADP (phosphorylation) | plakoglobin(h) + ATP --Fyn(h)--> plakoglobin(h){pY133}{pY549} + ADP (phosphorylation) | plakoglobin(h) + ATP --Src(v.s.)--> plakoglobin(h){pY643} + ADP (phosphorylation) | plakoglobin(h) + TCF-4(h) <==> plakoglobin(h):TCF-4(h) (binding) | beta-catenin(h) + plakoglobin(h) + TCF-4(h) <==> beta-catenin(h):TCF-4(h):plakoglobin(h) (binding) | PS1(m.s.) + plakoglobin(h) <==> PS1(m.s.):plakoglobin(h) (binding) | PS1(m.s.) + TCF-4(m.s.) + plakoglobin(h) <==> PS1(m.s.):TCF-4(m.s.):plakoglobin(h) (binding) | TCF-4(m.s.) + plakoglobin(h) <==> TCF-4(m.s.):plakoglobin(h) (binding) | actin(h) + vimentin(h) + plakoglobin(h) + beta-catenin(h) + alpha-catenin(h) + VE-cadherin(h) <==> actin(h):vimentin(h):plakoglobin(h):beta-catenin(h):alpha-catenin(h):VE-cadherin(h) (binding) | plakoglobin(h) + alpha-catenin(h) + beta-catenin(h) + VE-cadherin(h) <==> plakoglobin(h):alpha-catenin(h):beta-catenin(h):VE-cadherin(h) (binding) | beta-catenin(h) + plakoglobin(h) + vimentin(h) + VE-cadherin(h) <==> beta-catenin(h):plakoglobin(h):vimentin(h):VE-cadherin(h) (binding) | plakoglobin(h) + muc1(m.s.) <==> plakoglobin(h):muc1(m.s.) (binding) | ICAT(h) + plakoglobin(h) <==> ICAT(h):plakoglobin(h) (binding) | prohibitin-2(h) + plakoglobin(h) <==> prohibitin-2(h):plakoglobin(h) (binding) | Ecalectin(h) + plakoglobin(h) <==> Ecalectin(h):plakoglobin(h) (binding) | cIAP-1(h) + plakoglobin(h) <==> cIAP-1(h):plakoglobin(h) (binding) | plakoglobin(h) + IkappaB-epsilon(h) <==> plakoglobin(h):IkappaB-epsilon(h) (binding) | plakoglobin(h) + ribc2(h) <==> plakoglobin(h):ribc2(h) (binding) | plakoglobin(h) + FLJ10204(h) <==> plakoglobin(h):FLJ10204(h) (binding) | JUP(h) --> plakoglobin(h) (expression). | PS1(m.s.) + plakoglobin(h) <==> PS1(m.s.):plakoglobin(h) (binding) | TCF-4(m.s.) + plakoglobin(h) <==> TCF-4(m.s.):plakoglobin(h) (binding) | PS1(m) + plakoglobin(h) <==> PS1(m):plakoglobin(h) (binding) | desmoplakin(h) + plakoglobin(h) <==> desmoplakin(h):plakoglobin(h) (binding) | JUP(h) --> plakoglobin(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
20 | Phosphotyrosine. | Swiss-Prot 53.0 | 182 | Phosphoserine. | Swiss-Prot 53.0 | 664 | Phosphoserine. | Swiss-Prot 53.0 | 19 | Phosphotyrosine | 15951569 | Phospho.ELM 6.0 | 181 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 663 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr17 |
Promoter: 37195975 - 37197975 | Agilent_014791 |
chr17 |
Promoter: 37195975 - 37197975 | GSE27584 |
chr17 |
Promoter: 37195975 - 37197975 | GSE27584 |
chr17 |
Promoter: 37195975 - 37197975 | Agilent_014791_44K |