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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 4088 |
Name | SMAD3 |
Synonymous | HSPC193|HsT17436|JV15-2|LDS1C|MADH3;SMAD family member 3;SMAD3;SMAD family member 3 |
Definition | MAD homolog 3|MAD, mothers against decapentaplegic homolog 3|SMA- and MAD-related protein 3|SMAD, mothers against DPP homolog 3|hMAD-3|hSMAD3|mad homolog JV15-2|mad protein homolog|mad3|mothers against DPP homolog 3|mothers against decapentaplegic homolog |
Position | 15q22.33 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Smad3(h) + NTP --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad3(h){p} + NDP (phosphorylation) | Smad3(h) + ATP --TGFbetaR-I(h)--> Smad3(h){p} + ADP (phosphorylation) | Smad2-L(h) + Smad3(h) --TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding) | Smad3(h) + Smurf-2(h) <==> Smad3(h):Smurf-2(h) (binding) | SARA(h) + Smad3(h) <==> SARA(h):Smad3(h) (binding) | HEF1(h) + Smad3(h) <==> HEF1(h):Smad3(h) (binding) | Smad2-L(h) + Smad3(h) --TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding) | TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h) + Smad3(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h):Smad3(h) (binding) | Smad3(h) + smad4(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding) | Smad2-L(h) + Smad3(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding) | Smad3(h) + smad4(h) --TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding) | Smad3(h) + NTP --PKCgamma(r)--> Smad3(h){p} + NDP (phosphorylation) | Smad3(h) --> MMP1(h) (DNA binding). | Smad3(h) --> JUN(h) (DNA binding). | Smad3(h) --> Col7A1(h) (DNA binding). | Smad3(h) --> SERPINE1(h) (DNA binding). | Smad3(h) --> Junb(m) (DNA binding). | Smad3(h) --> SMAD7(m) (DNA binding). | Smad3(h) --> vent-2(x) (DNA binding). | Smad3(h) + TGIF(h) <==> Smad3(h):TGIF(h) (binding). | SKIP(h) + Smad3(h) <==> SKIP(h):Smad3(h) (binding). | p62Dok-1(m) + Smad3(h) <==> p62Dok-1(m):Smad3(h) (binding) | MAGI-2(m) + Smad3(h) <==> MAGI-2(m):Smad3(h) (binding) | ActR-II(m) + MAGI-2(m) + Smad3(h) <==> ActR-II(m):MAGI-2(m):Smad3(h) (binding) | beta-catenin(h) + Smad3(h) <==> beta-catenin(h):Smad3(h) (binding) | LEF-1(m) + Smad3(h) <==> LEF-1(m):Smad3(h) (binding) | LEF1-isoform1(h) + Smad3(h) <==> LEF1-isoform1(h):Smad3(h) (binding) | Evi-1(h) + Smad3(h) <==> Evi-1(h):Smad3(h) (binding) | Smad3(h) + smad4(h) <==> Smad3(h):smad4(h) (binding) | Smad3(h) --> twin(x) (DNA binding; transactivation). | Smad3(h) + HIF-1alpha(h) <==> Smad3(h):HIF-1alpha(h) (binding) | HNF-4alpha(h) + Smad3(h) <==> HNF-4alpha(h):Smad3(h) (binding). | HNF-4alpha(r) + Smad3(h) <==> HNF-4alpha(r):Smad3(h) (binding). | Smad3(h) --> PTHLH(h) (DNA binding; transactivation). | Smad3(h) --> COL1A2(h) (DNA binding; transactivation). | Smad3(h) + NICD1(m) <==> Smad3(h):NICD1(m) (binding) | Smad3(h) + axin(r) <==> Smad3(h):axin(r) (binding) | conductin(r) + Smad3(h) <==> conductin(r):Smad3(h) (binding) | axin(r) + Smad3(h) + TGFbetaR-I(m.s.) <==> axin(r):Smad3(h):TGFbetaR-I(m.s.) (binding) | SARA(m.s.) + Smad3(h) <==> SARA(m.s.):Smad3(h) (binding) | Smad3(h) --> Smad3(h) (translocation) | 4E-T(m) + Smad3(h) <==> 4E-T(m):Smad3(h) (binding) | Sf3b-2(m) + Smad3(h) <==> Sf3b-2(m):Smad3(h) (binding) | Smad3(h) + Pex-6(m) <==> Smad3(h):Pex-6(m) (binding) | Smad3(h) + Znf-198(m) <==> Smad3(h):Znf-198(m) (binding) | EIF4ENIF1(m.s.) + Smad3(h) <==> EIF4ENIF1(m.s.):Smad3(h) (binding) | SF3B2(m.s.) + Smad3(h) <==> SF3B2(m.s.):Smad3(h) (binding) | PEX6(m.s.) + Smad3(h) <==> PEX6(m.s.):Smad3(h) (binding) | ZNF198(m.s.) + Smad3(h) <==> ZNF198(m.s.):Smad3(h) (binding) | p68(m) + Smad3(h) <==> p68(m):Smad3(h) (binding) | Dvl-1(m) + Smad3(h) <==> Dvl-1(m):Smad3(h) (binding) | Par3(m) + Smad3(h) <==> Par3(m):Smad3(h) (binding) | Smad3(h) + Erbin(m) <==> Smad3(h):Erbin(m) (binding) | Dvl-1(m.s.) + Smad3(h) <==> Dvl-1(m.s.):Smad3(h) (binding) | Erbin(m.s.) + Smad3(h) <==> Erbin(m.s.):Smad3(h) (binding) | Smad3(h) + Par3(m.s.) <==> Smad3(h):Par3(m.s.) (binding) | col1a2(m) + Smad3(h) <==> col1a2(m):Smad3(h) (binding) | COL3A-1(m) + Smad3(h) <==> COL3A-1(m):Smad3(h) (binding) | COL5A-2(m) + Smad3(h) <==> COL5A-2(m):Smad3(h) (binding) | Smad3(h) + col1a2(m.s.) <==> Smad3(h):col1a2(m.s.) (binding) | COL3A1(m.s.) + Smad3(h) <==> COL3A1(m.s.):Smad3(h) (binding) | COL5A2(m.s.) + Smad3(h) <==> COL5A2(m.s.):Smad3(h) (binding) | Smad3(h) + AR-isoform1(h) <==> Smad3(h):AR-isoform1(h) (binding) | Smad3(h) + HDAC1(h) <==> Smad3(h):HDAC1(h) (binding) | HDAC1(h) + Smad3(h) <==> HDAC1(h):Smad3(h) (binding) | c-Ski(m.s.) + Smad3(h) <==> c-Ski(m.s.):Smad3(h) (binding) | SnoN(m.s.) + Smad3(h) <==> SnoN(m.s.):Smad3(h) (binding) | Smad3(h) + TGIF(m.s.) <==> Smad3(h):TGIF(m.s.) (binding) | sin3a(m.s.) + Smad3(h) <==> sin3a(m.s.):Smad3(h) (binding) | TCF-4(h) + Smad3(h) <==> TCF-4(h):Smad3(h) (binding) | foxl2(m) + Smad3(h) <==> foxl2(m):Smad3(h) (binding) | Smad3(h) --> TNC(h) (DNA binding). | Smad3(h) + mkl1(ca) <==> Smad3(h):mkl1(ca) (binding) | Smad3(h) + mkl2(ca) <==> Smad3(h):mkl2(ca) (binding) | Smad3(h) --> c-myc(h) (DNA binding). | SMAD3(h) --> Smad3(h) (expression). | Smad3(h) --> Smad3(h) (translocation) | Sox9(r) + Smad3(h) <==> Sox9(r):Smad3(h) (binding) | c-Myc(h) + Smad3(h) <==> c-Myc(h):Smad3(h) (binding) | c-Myc(m.s.) + Smad3(h) <==> c-Myc(m.s.):Smad3(h) (binding) | Smad3(h) + p53(h) <==> Smad3(h):p53(h) (binding) | Smad3(h) --> alpha-actin-2(m) (increase of promoter activity) | Smad3(h) --> collagen-IIalpha1(h) (increase of abundance) | Smad3(h) + axin(r) <==> Smad3(h):axin(r) (binding) | Smad3(h) + 3 ATP --Cdk4(h)--> Smad3(h){pT8}{pT178}{pS212} + 3 ADP (phosphorylation) | Smad3(h) + 3 ATP --Cdk2(h)--> Smad3(h){pT8}{pT178}{pS212} + 3 ADP (phosphorylation) | Smad3(h) + 3 ATP --ERK(h)--> Smad3(h){pT178}{pS203}{pS207} + 3 ADP (phosphorylation) | Smad3(h) + ATP --> Smad3(h){p} + ADP (phosphorylation) | DACH1(h) + Smad3(h) <==> DACH1(h):Smad3(h) (binding) | Smad3(h) + c-Ski(h) <==> Smad3(h):c-Ski(h) (binding) | Smad3(h) + PML(h) <==> Smad3(h):PML(h) (binding) | PML(h) + Smad3(h) + SARA(m.s.) <==> PML(h):Smad3(h):SARA(m.s.) (binding) | Dab2(h) + Smad3(h) <==> Dab2(h):Smad3(h) (binding) | Cdc25A(h) + Smad3(h) <==> Cdc25A(h):Smad3(h) (binding) | Smad3(h) + ATP --> Smad3(h){pS} + ADP (phosphorylation) | p300(h) + Smad3(h) <==> p300(h):Smad3(h) (binding) | Smad3(h) + PDK1(h) <==> Smad3(h):PDK1(h) (binding) | Smad3(h) + ATP --PDK1(h)--> Smad3(h){p} + ADP (phosphorylation) | Smad3(h) --> TGFB2(h) (DNA binding). | brca1(h) + Smad3(h) <==> brca1(h):Smad3(h) (binding) | Smad3(h) --> SERPINE1(h) (DNA binding). | Smad3(h) --> FBLN5(h) (DNA binding). | Smad3(h) --> Gast(m) (DNA binding). | pax6(m.s.) + Smad3(h) <==> pax6(m.s.):Smad3(h) (binding) | Smad3(h) --> ELN(h) (DNA binding). | ER-alpha(h) + Smad3(h) <==> ER-alpha(h):Smad3(h) (binding) | Smad3(h) --> SMAD7(h) (DNA binding). | Smad3(h) --> TERT(h) (DNA binding). | Smad3(h) --> MMP13(h) (DNA binding). | Smad3(h) --/ SEPP1(h) (DNA binding; transrepression). | Smad3(h) --> ACTA2(h) (DNA binding). | Smad3(h) --> IgH(m) (DNA binding). | Smad3(h) --> c-myc(h) (DNA binding). | SMAD3(h) --> Smad3(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
423 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 425 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 422 | Phosphoserine (MAP3K7) | 9380693 | Phospho.ELM 6.0 | 423 | Phosphoserine (MAP3K7) | 9380693 | Phospho.ELM 6.0 | 425 | Phosphoserine (MAP3K7) | 9380693 | Phospho.ELM 6.0 | 8 | Phosphothreonine (CDK2;CDK4) | 15241418;15520018 | Phospho.ELM 6.0 | 213 | Phosphoserine (CDK2;CDK4) | 15241418;15520018;10197981 | Phospho.ELM 6.0 | 179 | Phosphothreonine (CDK2;CDK4) | 15241418;15520018;10197981;16156666 | Phospho.ELM 6.0 | 204 | Phosphoserine (MAPK1) | 15241418;15520018;10197981;16156666 | Phospho.ELM 6.0 | 208 | Phosphoserine (MAPK1) | 15241418;15520018;10197981;16156666 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr15 |
Promoter: 65143749 - 65145749 | Agilent_014791 |
chr15 |
Promoter: 65143749 - 65145749 | GSE27584 |
chr15 |
Promoter: 65143749 - 65145749 | Agilent_014791_44K |
chr15 |
Promoter: 65143749 - 65145749 | Agilent_014791 |