Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

4830

Name

NME1

Synonymous

AWD|GAAD|NB|NBS|NDKA|NDPK-A|NDPKA|NM23|NM23-H1;non-metastatic cells 1, protein (NM23A) expressed in;NME1;non-metastatic cells 1, protein (NM23A) expressed in

Definition

NDP kinase A|granzyme A-activated DNase|metastasis inhibition factor nm23|nucleoside diphosphate kinase A|tumor metastatic process-associated protein

Position

17q21.3

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

Tiam-1(h) + NDKA(h) <==> Tiam-1(h):NDKA(h) (binding)
NDKA(h) + ATP --> NDKA(h){pH} + ADP (phosphorylation; automodification)
Hsp70(h) + STIP1(h) + GAPD(h) + NDPKB(h) + NDKA(h) <==> Hsp70(h):STIP1(h):GAPD(h):NDPKB(h):NDKA(h) (binding)
NDKA(h) + Oct-1(h) <==> NDKA(h):Oct-1(h) (binding)
NDKA(h) + GAPD(h) <==> NDKA(h):GAPD(h) (binding)
NDKA(h) + NPAT(h) <==> NDKA(h):NPAT(h) (binding)
NDPKB(h) + NDKA(h) + GAPD(h) + STIP1(h) + NPAT(m.s.) <==> NDPKB(h):NDKA(h):GAPD(h):STIP1(h):NPAT(m.s.) (binding)
2 NDKA(h) <==> (NDKA(h))2 (binding)
NDKA(h) + nucleoside diphosphate kinase 3(h) <==> NDKA(h):nucleoside diphosphate kinase 3(h) (binding)
NDKA(h) + nucleoside diphosphate kinase, mitochondrial(h) <==> NDKA(h):nucleoside diphosphate kinase, mitochondrial(h) (binding)
NDKA(h) + DNA-directed RNA polymerases I and III subunit RPAC1(h) <==> NDKA(h):DNA-directed RNA polymerases I and III subunit RPAC1(h) (binding)
NDKA(h) + GRASP55(h) <==> NDKA(h):GRASP55(h) (binding)
NDKA(h) + FLJ10204(h) <==> NDKA(h):FLJ10204(h) (binding)
NDKA(h) + p53(h) <==> NDKA(h):p53(h) (binding)
NDKA(h) --> p53(h) (increase of abundance)
NDKA(h) --> p21Cip1(h) (increase of abundance)
NDKA(h) --> Bax(h) (increase of abundance)
NDKA(h) --> p53(m.s.):mdm2(m.s.) (decrease of binding)
NDKA(h) --> p53(h):mdm2(h) (decrease of binding)
GIF(h) + NDKA(h) <==> GIF(h):NDKA(h) (binding)
GIF(h) + NDKA(h) <==> GIF(h):NDKA(h) (binding)
NDKA(h) + ATP --> NDKA(h){p} + ADP (phosphorylation; automodification)
NDKA(h) --> mdm2(h):p53(h) (decrease of binding)
NDKA(h) --> p53(m.s.){ub} (decrease of ubiquitination)
NDKA(h) --> SGK-1(m){p} (decrease of phosphorylation)
NDKA(h) --> AKT(m){pT308} (decrease of phosphorylation)
NDKA(h) --> bad(m){pS136} (decrease of phosphorylation)
NDKA(h) --> GIF(h):JAB1(m.s.) (decrease of binding)
NDKA(h) --> ERK1(m){p} (decrease of phosphorylation)
NDKA(h) --> ERK2(m){p} (decrease of phosphorylation)
NME1(h) --> NDKA(h) (expression).
Rac1(h):GDP + ATP --NDKA(h)--> Rac1(h):GTP + ADP (phosphorylation)
NDKA-isoform1(h) + ATP --> NDKA-isoform1(h){p} + ADP (phosphorylation; automodification)
NDKA-isoform1(h) + RORbeta(r) <==> NDKA-isoform1(h):RORbeta(r) (binding)
NDKA-isoform1(h) + RORalpha(h) <==> NDKA-isoform1(h):RORalpha(h) (binding)
muc1-p16(h) + NDKA-isoform1(h) <==> muc1-p16(h):NDKA-isoform1(h) (binding)
NME1(h) --> NDKA-isoform1(h) (expression).
Rad(m.s.):GTP --NDKA-isoform1(h)--> Rad(m.s.):GDP + p (hydrolysis)
Rad(m.s.):GDP + ATP --NDKA-isoform1(h)--> Rad(m.s.):GTP + ADP (exchange)
GEM(m.s.):GDP + ATP --NDKA-isoform1(h)--> GEM(m.s.):GTP + ADP (exchange)
Ras(m.s.):GDP + ATP --NDKA-isoform1(h)--> Ras(m.s.):GTP + ADP (exchange)
NME1(h) --> NDKA-isoform2(h) (expression).
NME1(h) --> NDKA-isoform3(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

44Phosphoserine8245015;8810265Phospho.ELM 6.0
120Phosphoserine8810265Phospho.ELM 6.0
122Phosphoserine8810265Phospho.ELM 6.0
125Phosphoserine8810265Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr17

Promoter: 46584419 - 46586419Agilent_014791

chr17

Promoter: 46584419 - 46586419GSE27584

chr17

Promoter: 46584419 - 46586419GSE27584


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