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General information | Expression | Regulation | Mutation | Interaction |
Basic Information |
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Gene ID | 4830 |
Name | NME1 |
Synonymous | AWD|GAAD|NB|NBS|NDKA|NDPK-A|NDPKA|NM23|NM23-H1;non-metastatic cells 1, protein (NM23A) expressed in;NME1;non-metastatic cells 1, protein (NM23A) expressed in |
Definition | NDP kinase A|granzyme A-activated DNase|metastasis inhibition factor nm23|nucleoside diphosphate kinase A|tumor metastatic process-associated protein |
Position | 17q21.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
Regulation From TransFac database |
Tiam-1(h) + NDKA(h) <==> Tiam-1(h):NDKA(h) (binding) | NDKA(h) + ATP --> NDKA(h){pH} + ADP (phosphorylation; automodification) | Hsp70(h) + STIP1(h) + GAPD(h) + NDPKB(h) + NDKA(h) <==> Hsp70(h):STIP1(h):GAPD(h):NDPKB(h):NDKA(h) (binding) | NDKA(h) + Oct-1(h) <==> NDKA(h):Oct-1(h) (binding) | NDKA(h) + GAPD(h) <==> NDKA(h):GAPD(h) (binding) | NDKA(h) + NPAT(h) <==> NDKA(h):NPAT(h) (binding) | NDPKB(h) + NDKA(h) + GAPD(h) + STIP1(h) + NPAT(m.s.) <==> NDPKB(h):NDKA(h):GAPD(h):STIP1(h):NPAT(m.s.) (binding) | 2 NDKA(h) <==> (NDKA(h))2 (binding) | NDKA(h) + nucleoside diphosphate kinase 3(h) <==> NDKA(h):nucleoside diphosphate kinase 3(h) (binding) | NDKA(h) + nucleoside diphosphate kinase, mitochondrial(h) <==> NDKA(h):nucleoside diphosphate kinase, mitochondrial(h) (binding) | NDKA(h) + DNA-directed RNA polymerases I and III subunit RPAC1(h) <==> NDKA(h):DNA-directed RNA polymerases I and III subunit RPAC1(h) (binding) | NDKA(h) + GRASP55(h) <==> NDKA(h):GRASP55(h) (binding) | NDKA(h) + FLJ10204(h) <==> NDKA(h):FLJ10204(h) (binding) | NDKA(h) + p53(h) <==> NDKA(h):p53(h) (binding) | NDKA(h) --> p53(h) (increase of abundance) | NDKA(h) --> p21Cip1(h) (increase of abundance) | NDKA(h) --> Bax(h) (increase of abundance) | NDKA(h) --> p53(m.s.):mdm2(m.s.) (decrease of binding) | NDKA(h) --> p53(h):mdm2(h) (decrease of binding) | GIF(h) + NDKA(h) <==> GIF(h):NDKA(h) (binding) | GIF(h) + NDKA(h) <==> GIF(h):NDKA(h) (binding) | NDKA(h) + ATP --> NDKA(h){p} + ADP (phosphorylation; automodification) | NDKA(h) --> mdm2(h):p53(h) (decrease of binding) | NDKA(h) --> p53(m.s.){ub} (decrease of ubiquitination) | NDKA(h) --> SGK-1(m){p} (decrease of phosphorylation) | NDKA(h) --> AKT(m){pT308} (decrease of phosphorylation) | NDKA(h) --> bad(m){pS136} (decrease of phosphorylation) | NDKA(h) --> GIF(h):JAB1(m.s.) (decrease of binding) | NDKA(h) --> ERK1(m){p} (decrease of phosphorylation) | NDKA(h) --> ERK2(m){p} (decrease of phosphorylation) | NME1(h) --> NDKA(h) (expression). | Rac1(h):GDP + ATP --NDKA(h)--> Rac1(h):GTP + ADP (phosphorylation) | NDKA-isoform1(h) + ATP --> NDKA-isoform1(h){p} + ADP (phosphorylation; automodification) | NDKA-isoform1(h) + RORbeta(r) <==> NDKA-isoform1(h):RORbeta(r) (binding) | NDKA-isoform1(h) + RORalpha(h) <==> NDKA-isoform1(h):RORalpha(h) (binding) | muc1-p16(h) + NDKA-isoform1(h) <==> muc1-p16(h):NDKA-isoform1(h) (binding) | NME1(h) --> NDKA-isoform1(h) (expression). | Rad(m.s.):GTP --NDKA-isoform1(h)--> Rad(m.s.):GDP + p (hydrolysis) | Rad(m.s.):GDP + ATP --NDKA-isoform1(h)--> Rad(m.s.):GTP + ADP (exchange) | GEM(m.s.):GDP + ATP --NDKA-isoform1(h)--> GEM(m.s.):GTP + ADP (exchange) | Ras(m.s.):GDP + ATP --NDKA-isoform1(h)--> Ras(m.s.):GTP + ADP (exchange) | NME1(h) --> NDKA-isoform2(h) (expression). | NME1(h) --> NDKA-isoform3(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
Location (AA) |
PTM type |
Literature |
Database |
44 | Phosphoserine | 8245015;8810265 | Phospho.ELM 6.0 | 120 | Phosphoserine | 8810265 | Phospho.ELM 6.0 | 122 | Phosphoserine | 8810265 | Phospho.ELM 6.0 | 125 | Phosphoserine | 8810265 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
Chromosome |
Location |
Source |
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chr17 |
Promoter: 46584419 - 46586419 | Agilent_014791 |
chr17 |
Promoter: 46584419 - 46586419 | GSE27584 |
chr17 |
Promoter: 46584419 - 46586419 | GSE27584 |
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